Tag: technologies (page 2 of 6)

NASA Challenges People to Come Up With Designs for Mars Habitat –





Excerpt from perfscience.com

The space agency NASA has asked public to submit designs for a Mars habitat. NASA, along with the National Additive Manufacturing Innovation Institute, is holding a competition to design and build a 3-D printed habitat for deep space explorations like journey to Mars.  The multi-phase 3-D Printed Habitat Challenge has been specifically designed to advance the additive construction technology that is needed to develop sustainable housing solutions for earth and beyond.  As per experts, shelter is among most basic and crucial requirement for humans but carrying bulks of material to build up a habitat during a deep space mission would unnecessarily take the place in cargo that could be used for something important.  The first phase of the competition that was announced on Saturday will run through September 27. This phase calls on participants to develop state-of-the-art architectural concepts that take advantage of the unique capabilities 3-D printing offers.  The top 30 submissions will be considered and judged. Also winners will be awarded with prize money of $50,000 at the 2015 World Maker Faire in New York.  Sam Ortega, Centennial Challenges program manager, said, “This challenge definitely raises the bar from what we are currently capable of, and we are excited to see what the maker community does with it”... 
The space agency NASA has asked public to submit designs for a Mars habitat. NASA, along with the National Additive Manufacturing Innovation Institute, is holding a competition to design and build a 3-D printed habitat for deep space explorations like journey to Mars.
The multi-phase 3-D Printed Habitat Challenge has been specifically designed to advance the additive construction technology that is needed to develop sustainable housing solutions for earth and beyond.
As per experts, shelter is among most basic and crucial requirement for humans but carrying bulks of material to build up a habitat during a deep space mission would unnecessarily take the place in cargo that could be used for something important.
The first phase of the competition that was announced on Saturday will run through September 27. This phase calls on participants to develop state-of-the-art architectural concepts that take advantage of the unique capabilities 3-D printing offers.
The top 30 submissions will be considered and judged. Also winners will be awarded with prize money of $50,000 at the 2015 World Maker Faire in New York.
Sam Ortega, Centennial Challenges program manager, said, “This challenge definitely raises the bar from what we are currently capable of, and we are excited to see what the maker community does with it”.
Furthermore the second phase of the competition is divided into two levels i.e., the (Level 1) Structural Member Competition and the On-Site Habitat Competition (Level 2).
The Level 1 focuses on the fabrication technologies that are needed to manufacture structural components from a combination of indigenous materials and recyclables, or indigenous materials alone.
On the other hand, the Level 2 challenges competitors to construct full-scale habitats using indigenous materials or indigenous materials combined with recyclables.
- See more at: http://perfscience.com/content/2141815-nasa-challenges-people-come-designs-mars-habitat#sthash.vtPiW4bW.dpuf

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Report: Russian Rocket Carrying Mexican Satellite Crashes in Siberia

A Russian-built Proton rocket with a relay satellite blasts off from a launch pad in Kazakhstan (April 2014)
The Proton-M carrier rocket blasted off with the MexSat-1 communications satellite from the Baikonur cosmodrome in Kazakhstan



Excerpt from nytimes.com

MOSCOW — A Russian-made rocket ferrying a Mexican telecommunications satellite crashed in eastern Siberia minutes after its launching on Saturday, Russian news agencies reported, citing officials at the country’s space agency.

The Proton-M rocket was launched from the Baikonur Cosmodrome in Kazakhstan at 11:47 a.m. and crashed in the Chita region of Siberia about eight minutes later, the reports said.

The failure appeared to have occurred with the rocket’s third stage, which was intended to bring the satellite to an altitude of about 110 miles. At that point, it was supposed to be propelled by engines into geostationary orbit.

File photo: A Proton-M launch vehicle with three Glonass-M satellites onboard while being mounted on its launch pad at Baikonur cosmodrome, Kazakhstan, 28 June 2013


Instead, there was a catastrophic failure. The stream of telemetry data sent back by the rocket failed about a minute before the satellite was to enter orbit, the news agencies reported.

The Interfax agency quoted an unidentified official at Roscosmos, the Russian space agency, as saying there had been an “emergency engine shutdown of the third stage.”

The Proton rocket is the mainstay transporter for International Launch Services, a joint Russian-American satellite carrier business. The satellite, called Centenario, was being sent into orbit on behalf of Mexico’s Ministry of Communications and Transportation and had been manufactured by Boeing Satellite Systems.

According to a statement issued by International Launch Services before the launching, it was intended to provide “mobile satellite services to support national security, civil and humanitarian efforts and will provide disaster relief, emergency services, telemedicine, rural education and government agency operations.”

The Proton-M is regarded as a workhorse but has encountered numerous problems in its decades of service. In 2013, a leadership shake-up at Roscosmos was prompted in part by the fourth failed launch of a Proton-M rocket within three years.

Officials said further launchings would be suspended until the cause of Saturday’s crash was determined.

The Mexican ministry said International Launch Services would create a commission to investigate the accident.

It said the satellite loss was “100 percent” covered by insurance, a point that seemed aimed at a domestic population often skeptical of the government’s spending on big projects.

The ministry said it still planned to launch another communications satellite from Cape Canaveral, Fla., aboard a Lockheed Martin rocket in October.

Gerardo Ruiz Esparza, the transportation and communications secretary, said that the lost satellite and its launching were valued at $390 million.

“I regret the mission was not a success,” Mr. Esparza said. “If Mexico is joining in these high technologies, we are going to have to learn to live with the risks that are not uncommon in this industry. The benefit is not so much being in the space era so much as the service it could provide to Mexicans.”

Randal C. Archibold contributed reporting from Mexico City.

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Carl Sagan’s Solar Sail Goes On Test Flight On May 20: Why You Should Care

Excerpt  from techtimes.comMany of the technologies that are in use today such as the airplane and the internet were once ideas that became reality and it appears that this still goes true with the innovations of the future. Take for instance ...

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Spacecraft Falls From Orbit Over the Pacific, Russia Says






Excerpt from nytimes.com

CAPE CANAVERAL, Fla. — An unmanned Russian spaceship loitering in orbit after a failed cargo run to the International Space Station plunged into Earth's atmosphere late on Thursday, the Russian space agency reported.

The capsule, loaded with more than three tons of food, fuel and supplies for the station crew, fell from orbit at 10:04 p.m. Eastern time, the Russian space agency, Roscosmos, said in a statement.
At the time, the Progress-59 spacecraft was flying over the central Pacific Ocean, the statement said.

Most of the spacecraft was expected to burn up during its high-speed descent through the atmosphere, but small pieces of the structure could have survived and splashed down in the ocean.
“Only a few small pieces of structural elements could reach the planet's surface,” Roscosmos said in a statement earlier Thursday — similar to what happens at the end of routine Progress cargo missions.

The freighter was launched on April 28 from the Baikonur Cosmodrome in Kazakhstan, but never made to the station, a $100 billion research laboratory that flies about 250 miles above the earth.

Ground controllers lost contact with the Progress spaceship shortly after it separated from the upper stage of its Soyuz rocket about nine minutes after launch.

An investigation into the failed mission is underway, Roscosmos said. Russia has flown 62 Progress spacecraft to the station to deliver modules and cargo, two of which were not successful.
Various versions of the Progress freighters have been flying since 1978, supporting previous Soviet-era stations including Salyut 6, Salyut 7 and Mir. The capsules are designed to burn up in the atmosphere after delivering their cargo.

The United States hired privately owned Space Exploration Technologies, or SpaceX, and Orbital ATK to fly cargo to the station after the space shuttles were retired in 2011. SpaceX's missions have all been successful.

Orbital lost a cargo ship in October after a failed launch. Europe flew five ATV freighters to the station, all successfully, but has no plans to fly more. Japan is preparing for its fifth HTV cargo flight in August.

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Desperately Seeking ET: Fermi’s Paradox Turns 65 ~ Part 2

Excerpt from huffingtonpost.comIntroductionWhy is it so hard to find ET? After 50 years of searching, the SETI project has so far found nothing. In the latest development, on April 14, 2015 Penn State researchers announced that after searching through...

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Desperately Seeking Extraterrestrials ~ Fermi’s Paradox Turns 65 ~ Part 1

Excerpt from huffingtonpost.comIntroduction 65 years ago, in 1950, while having lunch with colleagues Edward Teller and Herbert York, Nobel physicist Enrico Fermi suddenly blurted out, "Where is everybody?" His question is now known as Fermi's p...

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Could Google’s Project Fi be cable’s answer to wireless?

 Excerpt from cnet.com Google's Project Fi wireless service has the potential to turn the mobile industry on its head. But not in the way you might expect. Last week, Google announce...

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Lab for genetic modification of human embryos just $2,000 away – report


Reuters / Christian Charisius



Reuters

With the right expertise in molecular biology, one could start a basic laboratory to modify human embryos using a genome-editing computer technique all for a couple thousand dollars, according to a new report.

Genetic modification has received heightened scrutiny recently following last week’s announcement that Chinese researchers had, for the first time, successfully edited human embryos’ genomes. 
The team at Sun Yat-Sen University in Guangzhou, China, used CRISPR (clustered regularly interspaced palindromic repeats), a technique that relies on “cellular machinery” used by bacteria in defense against viruses. 

This machinery is copied and altered to create specific gene-editing complexes, which include the wonder enzyme Cas9. The enzyme works its way into the DNA and can be used to alter the molecule from the inside. The combination is attached to an RNA guide that takes the gene-editing complex to its target, telling Cas9 where to operate. 

Use of the CRISPR technique is not necessarily relegated to the likes of cash-flush university research operations, according to a report by Business Insider. 


Geneticist George Church, who runs a top CRISPR research program at the Harvard Medical School, said the technique could be employed with expert knowledge and about half of the money needed to pay for an average annual federal healthcare plan in 2014 -- not to mention access to human embryos. 

"You could conceivably set up a CRISPR lab for $2,000,” he said, according to Business Insider. 

Other top researchers have echoed this sentiment. 

"Any scientist with molecular biology skills and knowledge of how to work with [embryos] is going to be able to do this,” Jennifer Doudna, a biologist at the University of California, Berkeley, recently told MIT Tech Review, which reported that Doudna co-discovered how to edit genetic code using CRISPR in 2012. 

Last week, the Sun Yat-Sen University research team said it attempted to cure a gene defect that causes beta-thalassemia (a genetic blood disorder that could lead to severe anemia, poor growth, skeletal abnormalities and even death) by editing the germ line. For that purpose they used a gene-editing technique based on injecting non-viable embryos with a complex, which consists of a protective DNA element obtained from bacteria and a specific protein. 

"I suspect this week will go down as a pivotal moment in the history of medicine," wrote science journalist Carl Zimmer for National Geographic.


Response to the new research has been mixed. Some experts say the gene editing could help defeat genetic diseases even before birth. Others expressed concern. 

“At present, the potential safety and efficacy issues arising from the use of this technology must be thoroughly investigated and understood before any attempts at human engineering are sanctioned, if ever, for clinical testing,” a group of scientists, including some who had worked to develop CRISPR, warned in Science magazine. 

Meanwhile, the director of the US National Institutes for Health (NIH) said the agency would not fund such editing of human embryo genes. 

“Research using genomic editing technologies can and are being funded by NIH,” Francis Collins said Wednesday. “However, NIH will not fund any use of gene-editing technologies in human embryos. The concept of altering the human germline in embryos for clinical purposes ... has been viewed almost universally as a line that should not be crossed.”

Although the discovery of CRISPR sequences dates back to 1987 – when it was first used to cure bacteria of viruses – its successes in higher animals and humans were only achieved in 2012-13, when scientists achieved a revolution by combining the resulting treatment system with Cas9 for the first time. 


On April 17, the MIT’s Broad Institute announced that has been awarded the first-ever patent for working with the Crisp-Cas9 system. 

The institute’s director, Eric Lander, sees the combination as “an extraordinary, powerful tool. The ability to edit a genome makes it possible to discover the biological mechanisms underlying human biology.”

The system’s advantage over other methods is in that it can also target several genes at the same time, working its way through tens of thousands of so-called 'guide' RNA sequences that lead them to the weapon to its DNA targets. 

Meanwhile, last month in the UK, a healthy baby was born from an embryo screened for genetic diseases, using karyomapping, a breakthrough testing method that allows doctors to identify about 60 debilitating hereditary disorders.

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Secretive X-37B Military Space Plane Preps for Another Mystery Mission


X-37B Space Plane in Orbit: Artist’s Concept
Artist's illustration of the U.S. Air Force's X-37B space plane in orbit. The mysterious spacecraft is scheduled to launch on its fourth mission on May 20, 2015.
Credit: NASA Marshall Space Flight Center




Excerpt from space.com


The United States Air Force's X-37B space plane will launch on its fourth mystery mission next month.
The unmanned X-37B space plane, which looks like a miniature version of NASA's now-retired space shuttle orbiter, is scheduled to blast off atop a United Launch Alliance Atlas V rocket from Florida's Cape Canaveral Air Force Station on May 20.

"We are excited about our fourth X-37B mission," Randy Walden, director of the Air Force Rapid Capabilities Office, said in a statement. "With the demonstrated success of the first three missions, we’re able to shift our focus from initial checkouts of the vehicle to testing of experimental payloads." 

The X-37B's payloads and specific activities are classified, so it's unclear exactly what the spacecraft does while zipping around the Earth. But Air Force officials have revealed a few clues about the upcoming mission.

"The Air Force Research Laboratory (AFRL), Space and Missile Systems Center (SMC) and the Air Force Rapid Capabilities Office (AFRCO) are investigating an experimental propulsion system on the X-37B on Mission 4," Capt. Chris Hoyler, an Air Force spokesman, told Space.com via email.  

"AFRCO will also host a number of advance materials onboard the X-37B for the National Aeronautics and Space Administration (NASA) to study the durability of various materials in the space environment," Hoyler added.

The Air Force owns two X-37B space planes, both of which were built by Boeing's Phantom Works division. The solar-powered spacecraft are about 29 feet long by 9.5 feet tall (8.8 by 2.9 meters), with a wingspan of 15 feet (4.6 m) and a payload bay the size of a pickup-truck bed. The X-37B launches vertically atop a rocket and lands horizontally on a runway, like the space shuttle did.

One of the two X-37B vehicles flew the program's first and third missions, which were known as OTV-1 and OTV-3, respectively. ("OTV" is short for "Orbital Test Vehicle.") The other spacecraft flew OTV-2. Air Force officials have not revealed which space plane will be going to orbit on the upcoming mission.

OTV-1 launched in April 2010 and landed in December of that year, staying in orbit for 225 days. OTV-2 blasted off in March 2011 and circled Earth for 469 days, coming down in June 2012. OTV-3 launched in December 2012 and stayed aloft for a record-breaking 675 days, finally landing in October 2014.

Recovery Crew Processes X-37B Space Plane
A recovery team processes the U.S. Air Force's X-37B space plane after the robotic spacecraft's successful landing at Vandenberg Air Force Base in California on Oct. 17, 2014. The touchdown marked the end of the X-37B’s third space mission.
Credit: Boeing

If Air Force officials know how long OTV-4 is going to last, they're not saying.

"The X-37B is designed for an on-orbit duration of 270 days," Hoyler said. "Longer missions have been demonstrated. As with previous missions, the actual duration will depend on test objectives, on-orbit vehicle performance and conditions at the landing facility."

The secrecy surrounding the X-37B and its payloads has fueled speculation in some quarters that the vehicle could be a space weapon of some sort. But Air Force officials have repeatedly refuted that notion.

"The primary objectives of the X-37B are twofold: reusable spacecraft technologies for America's future in space, and operating experiments which can be returned to, and examined, on Earth," Air Force officials wrote in on online X-37B fact sheet. 

"Technologies being tested in the program include advanced guidance, navigation and control; thermal protection systems; avionics; high-temperature structures and seals; conformal reusable insulation, lightweight electromechanical flight systems; and autonomous orbital flight, re-entry and landing."

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Why the U.S. Gave Up on the Moon

Moon nearside



Excerpt from spacenews.com


Recently, several space advocacy groups joined forces to form the Alliance for Space Development. Their published objectives include a mention of obvious near-term goals such as supporting the commercial crew program, transitioning from use of the International Space Station to future private space stations and finding ways to reduce the cost of access to space.  What is notably missing from these objectives and those of many other space agencies, companies and advocacy groups is any mention of building a permanent settlement on the moon. It’s as if the lunar surface has become our crazy uncle that we all acknowledge exists but we’d prefer not to mention (or visit).  What made the next logical step in mankind’s progression beyond the bounds of Earth such a taboo subject?  If, as the Alliance for Space Development suggests, our nation wishes to move toward a path of permanent space settlements, the most logical step is our own planet’s satellite.

Lunar base conception
A 2006 NASA conception of a lunar base. Credit: NASA


A base on the lunar surface is a better place to study space settlement than a space station or Mars for many reasons. Unlike a space station, the base does not have to contend with aerodynamic drag, attitude control issues or contamination and impingement from its own thrusters. Unlike a space station, which exists in a total vacuum and resource void, a lunar base has access to at least some surface resources in the forms of minerals, albeit fewer than might be available on Mars.  Many people naturally want to go directly to Mars as our next step. Even SpaceX has publicly stated this as its ultimate goal, with SpaceX President Gwynne Shotwell noting that “we’re not moon people.” However, Mars makes sense only if we think the technology is ready to safely support humans on another surface for long periods of time. Furthermore, budget restrictions make an ambitious goal like going immediately to Mars an unlikely prospect. Why are we afraid to take the seemingly necessary baby steps of developing the technology for a long-term base on a surface that can be reached in mere days instead of months?  The tendency to want to skip a lunar settlement is not a new phenomenon. Even before the first landing on the moon, U.S. and NASA political leadership was contemplating the future of manned space, and few of the visions involved a lunar base. The early space program was driven by Cold War competition with Moscow, and the kinds of ideas that circulated at the time involved milestones that seemed novel such as reusable spaceplanes, nuclear-powered rockets, space stations and missions to Mars. 

When the United States was on the verge of a series of landings on the moon, building a permanent base just didn’t seem like much of a new giant leap. NASA's ConstellationNASA’s Constellation program, featuring the Orion manned capsule set atop the Ares 1 launch vehicle, was meant to send astronauts back to the moon. Credit: NASA  The idea of a lunar landing mission was not reintroduced seriously until the George W. Bush administration and the introduction of the Constellation program. This program came at a complex time for NASA: The space shuttle was recovering from the Columbia disaster, the space station was in the midst of construction and the United States found itself with large budget deficits. However, despite its budgetary and schedule problems, which are common in any serious aerospace development project from space programs to jumbo-jet development, it provided NASA with a vision and a goal that were reasonable and sensible as next steps toward a long-term future of exploration beyond Earth. 

Constellation was nevertheless canceled, and we have since returned to a most uncommon sense.  The decision to avoid any sort of lunar activity in current space policy may have been biased by the Obama administration’s desire to move as far away as possible from the policies of the previous administration. 

Regardless of the cause, discussion of returning to the moon is no longer on the table.  Without the moon, the only feasible mission that NASA could come up with that is within reach given the current technology and budget is the Asteroid Redirect Mission.  
Even planetary scientists have spoken out against the mission, finding that it will provide little scientific value. It will also provide limited engineering and technology value, if we assume that our long-term goal is to permanently settle space. The experience gained from this sort of flight has little applicability to planetary resource utilization, long-term life support or other technologies needed for settlement.  

If we are to have a program of manned space exploration, we must decide what the long-term goals of such a program should be, and we should align our actions with those goals. When resources such as funding are limited, space agencies and political leaders should not squander these limited resources on missions that make no sense. Instead, the limited funding should be used to continue toward our long-term goals, accepting a slower pace or slight scale-back in mission scope.  Establishing a permanent human settlement in space is a noble goal, one that will eventually redefine humanity. Like explorers before us, it is also not a goal that will be achieved in a short period of time. We would be wise to keep our eyes on that goal and the road needed to get us there. And the next likely stop on that road is a permanent home just above our heads, on the surface of the brightest light in the night sky.  

Paul Brower is an aerospace systems engineer on the operations team for the O3b Networks satellite fleet. He previously worked in mission control at NASA for 10 years.
Recently, several space advocacy groups joined forces to form the Alliance for Space Development. Their published objectives include a mention of obvious near-term goals such as supporting the commercial crew program, transitioning from use of the International Space Station to future private space stations and finding ways to reduce the cost of access to space.
What is notably missing from these objectives and those of many other space agencies, companies and advocacy groups is any mention of building a permanent settlement on the moon. It’s as if the lunar surface has become our crazy uncle that we all acknowledge exists but we’d prefer not to mention (or visit).
What made the next logical step in mankind’s progression beyond the bounds of Earth such a taboo subject?
If, as the Alliance for Space Development suggests, our nation wishes to move toward a path of permanent space settlements, the most logical step is our own planet’s satellite.
Lunar base conception
A 2006 NASA conception of a lunar base. Credit: NASA
A base on the lunar surface is a better place to study space settlement than a space station or Mars for many reasons. Unlike a space station, the base does not have to contend with aerodynamic drag, attitude control issues or contamination and impingement from its own thrusters. Unlike a space station, which exists in a total vacuum and resource void, a lunar base has access to at least some surface resources in the forms of minerals, albeit fewer than might be available on Mars.
Many people naturally want to go directly to Mars as our next step. Even SpaceX has publicly stated this as its ultimate goal, with SpaceX President Gwynne Shotwell noting that “we’re not moon people.” However, Mars makes sense only if we think the technology is ready to safely support humans on another surface for long periods of time. Furthermore, budget restrictions make an ambitious goal like going immediately to Mars an unlikely prospect. Why are we afraid to take the seemingly necessary baby steps of developing the technology for a long-term base on a surface that can be reached in mere days instead of months?
The tendency to want to skip a lunar settlement is not a new phenomenon. Even before the first landing on the moon, U.S. and NASA political leadership was contemplating the future of manned space, and few of the visions involved a lunar base. The early space program was driven by Cold War competition with Moscow, and the kinds of ideas that circulated at the time involved milestones that seemed novel such as reusable spaceplanes, nuclear-powered rockets, space stations and missions to Mars. When the United States was on the verge of a series of landings on the moon, building a permanent base just didn’t seem like much of a new giant leap.
NASA's Constellation
NASA’s Constellation program, featuring the Orion manned capsule set atop the Ares 1 launch vehicle, was meant to send astronauts back to the moon. Credit: NASA
The idea of a lunar landing mission was not reintroduced seriously until the George W. Bush administration and the introduction of the Constellation program. This program came at a complex time for NASA: The space shuttle was recovering from the Columbia disaster, the space station was in the midst of construction and the United States found itself with large budget deficits. However, despite its budgetary and schedule problems, which are common in any serious aerospace development project from space programs to jumbo-jet development, it provided NASA with a vision and a goal that were reasonable and sensible as next steps toward a long-term future of exploration beyond Earth.
Constellation was nevertheless canceled, and we have since returned to a most uncommon sense.
The decision to avoid any sort of lunar activity in current space policy may have been biased by the Obama administration’s desire to move as far away as possible from the policies of the previous administration. Regardless of the cause, discussion of returning to the moon is no longer on the table.
Without the moon, the only feasible mission that NASA could come up with that is within reach given the current technology and budget is the Asteroid Redirect Mission.
Even planetary scientists have spoken out against the mission, finding that it will provide little scientific value. It will also provide limited engineering and technology value, if we assume that our long-term goal is to permanently settle space. The experience gained from this sort of flight has little applicability to planetary resource utilization, long-term life support or other technologies needed for settlement.
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If we are to have a program of manned space exploration, we must decide what the long-term goals of such a program should be, and we should align our actions with those goals. When resources such as funding are limited, space agencies and political leaders should not squander these limited resources on missions that make no sense. Instead, the limited funding should be used to continue toward our long-term goals, accepting a slower pace or slight scale-back in mission scope.
Establishing a permanent human settlement in space is a noble goal, one that will eventually redefine humanity. Like explorers before us, it is also not a goal that will be achieved in a short period of time. We would be wise to keep our eyes on that goal and the road needed to get us there. And the next likely stop on that road is a permanent home just above our heads, on the surface of the brightest light in the night sky.

Paul Brower is an aerospace systems engineer on the operations team for the O3b Networks satellite fleet. He previously worked in mission control at NASA for 10 years.
- See more at: http://spacenews.com/op-ed-why-the-u-s-gave-up-on-the-moon/#sthash.czfTscvg.dpuf

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Top Secret Government Programs That Your Not Supposed To Know About

Originally Posted at in5d.com The following is the alleged result of the actions of one or more scientists creating a covert, unauthorized notebook documenting their involvement with an Above Top Secret government program. Government publications and information obtained by the use of public tax monies cannot be subject to copyright. This document is released into the public domain for all citizens of the United States of America. THE ‘MAJIC PROJECTS’ SIGMA is the project whic [...]

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If the Moon Landings Were Real, Then Why is NASA Stumped by This?

Buck Rogers, Staff WriterWaking TimesDuring the cold war era the Soviet Union and the United States were locked in an arms and technology race, each nation wanting to prove their dominance over the other, each striving to be the next reigning superpower in a world still shattered by the second world war. The Soviet’s took the lead when in April of 1961, cosmonaut Yuri Gagarin successfully orbited the earth and returned home safely. In May, president John F. Kennedy ma [...]

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Biologists fear DNA editing procedure can alter human DNA




Excerpt from themarketbusiness.com

A group of biologists was alarmed with the use a new genome-editing technique to modify human DNA in a way that it can become hereditary.
The biologists worry that the new technique is so effective and easy to use that some physicians may push ahead with it before its safety can be weigh up. They also want the public to understand the ethical issues surrounding the technique, which could be used to cure genetic diseases, but also to enhance qualities like beauty or intelligence. The latter is a path that many ethicists believe should never be taken.


“You could exert control over human heredity with this technique, and that is why we are raising the issue,” said David Baltimore, a former president of the California Institute of Technology and a member of the group whose paper on the topic was published in the journal Science.

Ethicists have been concerned for decades about the dangers of altering the human germ line — meaning to make changes to human sperm, eggs or embryos that will last through the life of the individual and be passed on to future generations. Until now, these worries have been theoretical. But a technique invented in 2012 makes it possible to edit the genome precisely and with much greater ease. The technique has already been used to edit the genomes of mice, rats and monkeys, and few doubt that it would work the same way in people.

The new genome-editing technique holds the power to repair or enhance any human gene. “It raises the most fundamental of issues about how we are going to view our humanity in the future and whether we are going to take the dramatic step of modifying our own germline and in a sense take control of our genetic destiny, which raises enormous peril for humanity,” said George Daley, a stem cell expert at Boston Children’s Hospital and a member of the group.

The biologists writing in Science support continuing laboratory research with the technique, and few if any scientists believe it is ready for clinical use. Any such use is tightly regulated in the United States and Europe. American scientists, for instance, would have to present a plan to treat genetic diseases in the human germline to the Food and Drug Administration.

The paper’s authors, however, are concerned about countries that have less regulation in science. They urge that “scientists should avoid even attempting, in lax jurisdictions, germ line genome modification for clinical application in humans” until the full implications “are discussed among scientific and governmental organizations.”

Though such a moratorium would not be legally enforceable and might seem unlikely to exert global sway, there is a precedent. In 1975, scientists worldwide were asked to refrain from using a method for manipulating genes, the recombinant DNA technique, until rules had been established.

“We asked at that time that nobody do certain experiments, and in fact nobody did, to my knowledge,” said Baltimore, who was a member of the 1975 group. “So there is a moral authority you can assert from the U.S., and that is what we hope to do.”

Recombinant DNA was the first in a series of ever-improving steps for manipulating genetic material. The chief problem has always been one of accuracy, of editing the DNA at precisely the intended site, since any off-target change could be lethal. Two recent methods, known as zinc fingers and TAL effectors, came close to the goal of accurate genome editing, but both are hard to use. The new genome-editing approach was invented by Jennifer Doudna of the University of California, Berkeley, and Emmanuelle Charpentier of Umea University in Sweden.

Their method, known by the acronym Crispr-Cas9, co-opts the natural immune system with which bacteria remember the DNA of the viruses that attack them so they are ready the next time those same invaders appear. Researchers can simply prime the defense system with a guide sequence of their choice and it will then destroy the matching DNA sequence in any genome presented to it. Doudna is the lead author of the Science article calling for control of the technique and organized the meeting at which the statement was developed.

Though highly efficient, the technique occasionally cuts the genome at unintended sites. The issue of how much mistargeting could be tolerated in a clinical setting is one that Doudna’s group wants to see thoroughly explored before any human genome is edited.

Scientists also say that replacing a defective gene with a normal one may seem entirely harmless but perhaps would not be.
“We worry about people making changes without the knowledge of what those changes mean in terms of the overall genome,” Baltimore said. “I personally think we are just not smart enough — and won’t be for a very long time — to feel comfortable about the consequences of changing heredity, even in a single individual.”
Many ethicists have accepted the idea of gene therapy, changes that die with the patient, but draw a clear line at altering the germline, since these will extend to future generations. The British Parliament in February approved the transfer of mitochondria, small DNA-containing organelles, to human eggs whose own mitochondria are defective. But that technique is less far-reaching because no genes are edited.

There are two broad schools of thought on modifying the human germline, said R. Alta Charo, a bioethicist at the University of Wisconsin and a member of the Doudna group. One is pragmatic and seeks to balance benefit and risk. The other “sets up inherent limits on how much humankind should alter nature,” she said. 
Some Christian doctrines oppose the idea of playing God, whereas in Judaism and Islam there is the notion “that humankind is supposed to improve the world.” She described herself as more of a pragmatist, saying, “I would try to regulate such things rather than shut a new technology down at its beginning.”

Other scientists agree with the Doudna group’s message.
“It is very clear that people will try to do gene editing in humans,” said Rudolf Jaenisch, a stem cell biologist at the Whitehead Institute in Cambridge, Massachusetts, who was not a member of the Doudna group. “This paper calls for a moratorium on any clinical application, which I believe is the right thing to do.”
Writing in Nature last week, Edward Lanphier and other scientists involved in developing the rival zinc finger technique for genome editing also called for a moratorium on human germline modification, saying that use of current technologies would be “dangerous and ethically unacceptable.”

The International Society for Stem Cell Research said Thursday that it supported the proposed moratorium.

The Doudna group calls for public discussion but is also working to develop some more formal process, such as an international meeting convened by the National Academy of Sciences, to establish guidelines for human use of the genome-editing technique.

“We need some principled agreement that we want to enhance humans in this way or we don’t,” Jaenisch said. “You have to have this discussion because people are gearing up to do this.”

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