Tag: surrounding (page 2 of 8)

Jane Goodall Says SeaWorld ‘Should Be Closed Down’

May 1, 2015 / / 0 Comments

Jane Goodall


Excerpt from huffingtonpost.com

NEW YORK -- Jane Goodall wants to see SeaWorld go extinct.
The 81-year-old primatologist said whales and dolphins should never be held in captivity, and that the entertainment company known for its orca shows should be shuttered.

“They definitely should be closed down,” Goodall said in an interview with The Huffington Post earlier this month. 

She’s not alone. SeaWorld’s stock price has been plummeting since July 2013, when CNN released the documentary “Blackfish." The film exposed the misery endured by SeaWorld's trained orca and the dangers posed to trainers working with stressed-out carnivorous whales. 

seaworld stock
SeaWorld's stock price has declined precipitously since the 2013 release of "Blackfish."

One of the problems highlighted in "Blackfish" is that cetacea, the family of aquatic mammals that includes whales, dolphins and porpoises, communicate with sonar-like sound waves. When confined to tanks, Goodall noted, those waves echo back and create a hellish cacophony for the animals.

“When they are contained in these tanks … that is acoustical hell,” said Goodall, adding that her nonprofit organization, the Jane Goodall Institute, is urging aquariums across the country to free their whales. “The sounds bounce back from the walls of the tank.”

SeaWorld aggressively refuted many of the film's claims, including allegations that its whales were unhealthy and that the company tried to cover up details surrounding the 2010 death of trainer Dawn Brancheau, who was mauled by an orca. 

After the release of "Blackfish," SeaWorld saw a rapid decline in visitors, and with that, in the price of shares. But on Monday, Goldman Sachs upgraded the stock, optimistic that the company can retool its image as consumers start forgetting about the blockbuster documentary.

"Jane Goodall is a respected scientist and advocate for the world’s primates, but we couldn’t disagree more with her on this," Becca Bides, a SeaWorld spokeswoman, said in an emailed statement. 

"Zoos and marine mammal parks like SeaWorld allow people to experience animals in a way that is inspiring and educational."
Asked about the allegation that SeaWorld's tanks are detrimental to whales, Bides denied the claim, arguing that they are specially crafted to keep underwater noise levels quieter than the ambient ocean.

As of last December, SeaWorld held 22 orcas in its three U.S. marine parks, five of which were caught in the wild, according to the nonprofit advocacy group Whale and Dolphin Conservation. A total of 57 orcas are held in captivity around the world, the group notes. At least 160 orcas have died in captivity since 1961, and an additional 30 pregnant whales have miscarried or had stillborn calves.

Goodall said she remains hopeful that humans are gaining a greater sense of empathy for animals and losing interest in watching them perform for entertainment.

“It’s not only that they’re really big, highly intelligent and social animals so that the capture and confinement in itself is cruel,” she said of the captive orcas, but also that “they have emotions like ours.”
She welcomed the decision by Ringling Bros. and Barnum & Bailey Circus to eliminate elephants in its shows by 2018.

“If you see what happens to those baby elephants, the way they’re trained, it’s absolutely chilling,” said Goodall, who had a pendant in the shape of Africa hanging from her necklace. “They lose all of their young elephant playfulness, and then they can be trained.”

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Local Lick Observatory Astronomers Discover ‘Supersized Earths’ Surrounding Relatively Nearby Star

April 28, 2015 / / 0 Comments


A telescope at Lick Observatory on Mount Hamilton. (CBS)
A telescope at Lick Observatory on Mount Hamilton. (CBS)


Excerpt from cbslocal.com


SAN JOSE (CBS SF) – Astronomers at the Lick Observatory atop Mount Hamilton have confirmed the existence of three planets described as “supersized Earths” orbiting a star 54 light years away.
Researchers from the University of California, University of Hawaii, the University of California Observatories and Tennessee State University have been working for years to confirm the planets were there.

The planets orbit a star called HD 7924. They orbit at a distance closer than Mercury orbits our sun (35.9 million miles), and complete their orbits in five, 15 and 24 days, respectively.
“The three planets are unlike anything in our solar system, with masses seven to eight times the mass of Earth and orbits very close to their host star,” UC Berkeley graduate student Lauren Weiss said in a written statement.

The researchers used a robotic telescope called the “Automated Planet Finder,” which searches for planets around nearby stars that could be suitable for life. Most distant planets discovered by astronomers so far are gas giants like Jupiter.

Astronomers first found evidence of planets surrounding HD 7924 six years ago. The planets are not visible to the naked eye.

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Secretive X-37B Military Space Plane Preps for Another Mystery Mission

April 26, 2015 / / 0 Comments


X-37B Space Plane in Orbit: Artist’s Concept
Artist's illustration of the U.S. Air Force's X-37B space plane in orbit. The mysterious spacecraft is scheduled to launch on its fourth mission on May 20, 2015.
Credit: NASA Marshall Space Flight Center




Excerpt from space.com


The United States Air Force's X-37B space plane will launch on its fourth mystery mission next month.
The unmanned X-37B space plane, which looks like a miniature version of NASA's now-retired space shuttle orbiter, is scheduled to blast off atop a United Launch Alliance Atlas V rocket from Florida's Cape Canaveral Air Force Station on May 20.

"We are excited about our fourth X-37B mission," Randy Walden, director of the Air Force Rapid Capabilities Office, said in a statement. "With the demonstrated success of the first three missions, we’re able to shift our focus from initial checkouts of the vehicle to testing of experimental payloads." 

The X-37B's payloads and specific activities are classified, so it's unclear exactly what the spacecraft does while zipping around the Earth. But Air Force officials have revealed a few clues about the upcoming mission.

"The Air Force Research Laboratory (AFRL), Space and Missile Systems Center (SMC) and the Air Force Rapid Capabilities Office (AFRCO) are investigating an experimental propulsion system on the X-37B on Mission 4," Capt. Chris Hoyler, an Air Force spokesman, told Space.com via email.  

"AFRCO will also host a number of advance materials onboard the X-37B for the National Aeronautics and Space Administration (NASA) to study the durability of various materials in the space environment," Hoyler added.

The Air Force owns two X-37B space planes, both of which were built by Boeing's Phantom Works division. The solar-powered spacecraft are about 29 feet long by 9.5 feet tall (8.8 by 2.9 meters), with a wingspan of 15 feet (4.6 m) and a payload bay the size of a pickup-truck bed. The X-37B launches vertically atop a rocket and lands horizontally on a runway, like the space shuttle did.

One of the two X-37B vehicles flew the program's first and third missions, which were known as OTV-1 and OTV-3, respectively. ("OTV" is short for "Orbital Test Vehicle.") The other spacecraft flew OTV-2. Air Force officials have not revealed which space plane will be going to orbit on the upcoming mission.

OTV-1 launched in April 2010 and landed in December of that year, staying in orbit for 225 days. OTV-2 blasted off in March 2011 and circled Earth for 469 days, coming down in June 2012. OTV-3 launched in December 2012 and stayed aloft for a record-breaking 675 days, finally landing in October 2014.

Recovery Crew Processes X-37B Space Plane
A recovery team processes the U.S. Air Force's X-37B space plane after the robotic spacecraft's successful landing at Vandenberg Air Force Base in California on Oct. 17, 2014. The touchdown marked the end of the X-37B’s third space mission.
Credit: Boeing

If Air Force officials know how long OTV-4 is going to last, they're not saying.

"The X-37B is designed for an on-orbit duration of 270 days," Hoyler said. "Longer missions have been demonstrated. As with previous missions, the actual duration will depend on test objectives, on-orbit vehicle performance and conditions at the landing facility."

The secrecy surrounding the X-37B and its payloads has fueled speculation in some quarters that the vehicle could be a space weapon of some sort. But Air Force officials have repeatedly refuted that notion.

"The primary objectives of the X-37B are twofold: reusable spacecraft technologies for America's future in space, and operating experiments which can be returned to, and examined, on Earth," Air Force officials wrote in on online X-37B fact sheet. 

"Technologies being tested in the program include advanced guidance, navigation and control; thermal protection systems; avionics; high-temperature structures and seals; conformal reusable insulation, lightweight electromechanical flight systems; and autonomous orbital flight, re-entry and landing."

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Chicxulub Dinosaur-Killer Asteroid Impact To Be Probed For Answers To Extinction Mysteries

April 13, 2015 / / 0 Comments

Excerpt from techtimes.comScientists are seeking a core sample from the Chicxulub crater that marks the remains of an asteroid impact which ended the age of the dinosaurs nearly 66 million years ago.That geological feature will be probed by scientist...

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Tombs Filled with Dozens of Mummies Discovered in Peru

April 9, 2015 / / 0 Comments

A burial of a young woman found in the middle of a tomb. Analysis of her skeletal remains reveal that she suffered dental problems, including tooth loss. At one point in her life she suffered an internal hemorrhage in the meninges of her cranium. ...

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For the first time, scientists find complex organic molecules in an infant star system

April 8, 2015 / / 0 Comments



Artist impression of the protoplanetary disk surrounding the young star MWC 480. ALMA has detected the complex organic molecule methyl cyanide in the outer reaches of the disk in the region where comets are believed to form. This is another indication that complex organic chemistry, and potentially the conditions necessary for life, is universal. (B. Saxton/NRAO/AUI/NSF)



Excerpt from washingtonpost.com

We're not special. Or our complex organic molecules aren't, anyway. And that's good news in the hunt for extraterrestrial life.

In a new study published Wednesday in Nature, astronomers found the first signs of the complex, carbon-based molecules that make life possible on Earth in a protoplanetary disk; the region where cosmic building blocks gather to create planets in a brand-new star system. The cyanides found there are essential to life as we know it: without them, there would be no proteins.

"We know when our own solar system was very young, it was rich in water and complex organics. We know that from observing comets," explained study author Karin Öberg, an assistant professor of astronomy at Harvard. Comets have kept the molecules of our solar system's early days locked up tight ever since, which is why scientists are so eager to study them for clues about Earth's formation. These comets show us that certain organic molecules were common in our solar system's pre-planetary days.

But this is the first time we've seen evidence of such molecules ready to seed another star system with planets that could support life.
"We're finding that we're not that special," Öberg said. "Other young solar systems in the making are also rich in the same volatiles, and in similar proportions."

And in this case, she said, being not-special is a great thing: If other solar systems formed just the way ours did, we can hope that they formed some kind of life, too.

Öberg and her colleagues found the molecules using the Atacama Large Millimeter/submillimeter Array (ALMA), a radio telescope with some pretty sweet resolution. They spotted the complex organics as much as 15 billion kilometers from the star itself, which they believe is right smack dab in the middle of the system's comet-forming region. That means the organics could get locked away in comets, just as the ones in our solar system were, and go out to seed future planets with them (as some believe was the case with Earth).

"It was kind of a chance discovery, because we weren't targeting this specific molecule," Öberg said. So she and her team need to go back and look more systematically. She also hopes they'll be able to find more systems to look at. The star they've observed -- MWC 480, located some 455 light-years away in the Taurus star-forming region -- is twice the mass of the sun, so they also hope to find some that are more similar to our host star.

 "We of course want to know whether this is a really common thing or if we just lucked out on this one," Öberg said.

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Citizen Scientists Find Green Blobs in Hubble Galaxy Shots

April 3, 2015 / / 0 Comments





Excerpt from wired.com

In 2007, A Dutch schoolteacher named Hanny var Arkel discovered a weird green glob of gas in space. Sifting through pictures of galaxies online, as part of the citizen science project Galaxy Zoo, she saw a cloud, seemingly glowing, sitting next to a galaxy. Intrigued, astronomers set out to find more of these objects, dubbed Hanny’s Voorwerp (“Hanny’s object” in Dutch). Now, again with the help of citizen scientists, they’ve found 19 more of them, using the Hubble space telescope to snap the eight haunting pictures in the gallery above.



Since var Arkel found the first of these objects, hundreds more volunteers have swarmed to help identify parts of the universe in the Galaxy Zoo gallery. To find this new set, a couple hundred volunteers went through nearly 16,000 pictures online (seven people went through all of them), clicking yes/no/maybe as to whether they saw a weird green blob. Astronomers followed up on the galaxies they identified using ground-based telescopes, and confirmed 19 new galaxies surrounded by green gas.



What causes these wispy tendrils of gas to glow? Lurking at the center of each of these galaxies is a supermassive black hole, millions to billions times as massive as the sun, with gravity so strong that even light can’t escape them. As nearby gas and dust swirls into the black hole, like water circling a drain, that material heats up, producing lots of radiation—including powerful ultraviolet. Beaming out from the galaxy, that ultraviolet radiation strikes nearby clouds of gas, left over from past collisions between galaxies. And it makes the clouds glow an eerie green. “A lot of these bizarre forms we’re seeing in the images arise because these galaxies either interacted with a companion or show evidence they merged with a smaller galaxy,” says William Keel, an astronomer at the University of Alabama, Tuscaloosa.



The eight in this gallery, captured with Hubble, are especially weird. That’s because the quasar, the black-hole engine that’s supposed to be churning out the ultraviolet radiation, is dim—too dim, in fact, to be illuminating the green gas. Apparently, the once-bright quasar has faded. But because that UV light takes hundreds of thousands of years to travel, it can continue to illuminate the gas long after its light source has died away.  


Hubble finds phantom objects close to dead quasars

That glowing gas can tell astronomers a lot about the quasar that brought it to light. “What I’m so excited about is the fact that we can use them to do archaeology,” says Gabriela Canalizo, an astronomer at the University of California, Riverside, who wasn’t part of the new research. Because the streaks of gas are so vast, stretching up to tens of thousands of light years, the way they glow reveals the history of the radiation coming from the quasar. As the quasar fades, so will the gas’s glow, with the regions of gas closer to the quasar dimming first. By analyzing how the glow dwindles with distance from the quasar, astronomers can determine how fast the quasar is fading. “This was something we’ve never been able to do,” Canalizo says.

Measuring how fast the quasar fades allows astronomers to figure out exactly what’s causing it to turn off in the first place. “What makes them dim is running out of material to eat,” Canalizo says. That could happen if the quasar is generating enough radiation to blow away all the gas and dust surrounding the black hole—the same gas and dust that feeds it. Without a steady diet, the quasar is powerless to produce radiation. Only if more gas happens to make its way toward the black hole can the quasar turn on again. The glowing gas can provide details of this process, and if other mechanisms are at play.

With more powerful telescopes, astronomers will likely find many more. Hanny’s Verwoort, it turns out, may not be that weird after all.

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Why Luke Skywalker’s binary sunset may be real after all

March 30, 2015 / / 0 Comments






Excerpt from csmonitor.com

Researchers have found Jupiter-scale gas giants orbiting binary stars and estimate that Earth-like planets orbiting binary stars could be as numerous as rocky planets orbiting single-star systems.


For all the sci-fi charm of watching a pair of suns sink below a distant horizon on a planet in a galaxy far, far away, conventional wisdom has held that binary-star systems can't host Earth-scale rocky planets.

As the two stars orbit each other like square-dance partners swinging arm in arm, regular variations in their gravitational tug would disrupt planet formation at the relatively close distances where rocky planets tend to appear.

Not so fast, say two astrophysicists. They argue that only are Tatooine-like planets likely to be out there. They could be as numerous as rocky planets orbiting single-star systems – which is to say, there could be large number of them.

Building rocky planets in a binary system not only is possible, it's "not even that hard," says Scott Kenyon, an astrophysicist at the Harvard-Smithsonian Center for Astrophysics in Cambridge, Mass., who along with University of Utah astrophysicist Benjamin Bromley performed the calculations.
Researchers have found Jupiter-scale gas giants orbiting binary stars and have estimated that such gas giants are likely to be as common in binary systems as they are in systems with a single star.
"If that's true, then Earth-like planets around binaries are just as common as Earth-like planets around single stars," Dr. Kenyon says. "If they're not common, that tells you something about how they form or how they interact with the star over billions of years."

The modeling study grew out of work the two researchers were undertaking to figure out how the dwarf planet Pluto and its largest moon Charon manage to share space with four smaller moons that orbit the two larger objects. 

Pluto and Charon form a binary system that early in its history saw the two objects graze each other to generate a ring of dust that would become the additional moons.

The gravity the surrounding dust felt as Pluto and Charon swung about their shared center of mass would vary with clock-like precision.

Conventional wisdom held that this variable tug would trigger collisions at speeds too fast to allow the dust and larger chunks to merge into ever larger objects.

Kenyon and Dr. Bromley found that, in fact, the velocities would be smaller than people thought – no greater than the speeds would be around a single central object, where velocities are slow enough to allow the debris to bump gently and merge to build ever-larger objects.

They recognized that binary stars hosting planets are essentially scaled-up versions of the Pluto-Charon system. So they applied their calculations to a hypothetical binary star system with a circumstellar disk of dust and debris.

"The modest jostling in these orbits is the same modest jostling you'd get around a single star," Kenyon says, allowing rocky inner planets to form.

As for the Jupiter- or Neptune-scale planets found around binary stars, they would have formed farther out and migrated in over time, the researchers say, since there is too little material within the inner reaches of a circumstellar disk to build giant planets.

The duo's calculations imply that as more planets are discovered orbiting binary stars, a rising number of Tatooines will be among them. 

Tatooine "was science fiction," Kenyon says. But "it's not so far from science reality."

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NASA’s Orion Engineer Admits They Can’t Get Past Van Allen Radiation Belts

March 30, 2015 / / 0 Comments

‘If this does not get the skeptics going wild on the moon debate, we don’t know what will.In the video presentation above, NASA engineer Kelly Smith explains about many of the risks and pitfalls surrounding the new Orion Deep Space Mission to the planet Mars.Surprisingly, chief among Kelly’s concerns is whether or not his spacecraft can successfully pass through the perilous Van Allen Radiation Belts. Such is the prospective danger in fact, that NASA will have to [...]

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Boeing Receives Patent for a Force Field that Protects U.S. Military Vehicles from Blasts

March 24, 2015 / / 0 Comments

Excerpt from en.yibada.com The Boeing Company has received a patent from the U.S. Patent and Trademark Office for a device that generates a "force field" which deflects blasts from shells and explosive weapons. Technically, the patent is f...

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Amazing Images of Comet 67P/Churyumov-Gerasimenko

March 21, 2015 / / 0 Comments

Rosetta photo of Comet 67P/C-G.
Comet 67P/C-G is about as large as Central Park of Manhattan Island, New York

Excerpt from nytimes.com

By JONATHAN CORUM 


The European Space Agency’s Rosetta spacecraft caught up with Comet 67P/Churyumov-Gerasimenko last August, then dropped a lander onto the comet in November. Now Rosetta will follow the rubber-duck-shaped comet as it swings closer to the sun.
Scale in miles
Scale in km
Rosetta photo of Comet 67P/C-G.
1/2 MILE

March 9 Rosetta was 45 miles from Comet 67P/C-G when it photographed the comet’s head ringed with a halo of gas and dust. These jets extend from active areas of the comet’s surface and will become much more prominent over the next few months as the comet approaches the sun.
Rosetta photo of Comet 67P/C-G.
1/2 MILE

March 6 The comet’s head is angled down in this image of crisscrossing sunlit jets taken from 53 miles away.
Comet’s location when Rosetta was launched Rosetta launched in March 2004
Earth
Sun
Mars
Rendezvous
with Comet
67P/C-G
Orbit of
Jupiter
Rosetta today

Where is Rosetta? The Rosetta spacecraft took 10 years to match speed and direction with Comet 67P/C-G. The chase ended last August, and Rosetta will now follow the comet in its elliptical orbit as it moves closer to the sun. The spacecraft is no longer orbiting the comet because of increasing dust, but it is planning a series of close flybys.
Rosetta photo of Comet 67P/C-G.
1/2 MILE

March 6 Rosetta was 52 miles away when it looked up at the comet’s flat underbelly. The smooth plain at center covered with large boulders is named Imhotep.
Rosetta photo of Comet 67P/C-G.
1/2 MILE

Feb. 28 Rosetta captured a profile of the comet surrounded by curving jets of gas and dust from active regions. The spacecraft was 64 miles away.
Rosetta photo of Comet 67P/C-G.

Feb. 25–27 One day on Comet 67P/C-G is about 12 hours, the time it takes the comet to spin on its axis. The jets of gas and dust surrounding the comet are thought to curve from a combination of the comet’s rotation and the uneven gravity of its two-lobed structure.
Rosetta photo of Comet 67P/C-G.
1/2 MILE

Feb. 20 The comet’s sunlit underbelly casts a shadow obscuring the neck that joins the two lobes. Rosetta took this image from 74 miles away.
Rosetta photo of Comet 67P/C-G.
1 MILE

Feb. 18 Pale jets of gas and dust surround Comet 67P/C-G, seen from 123 miles away. Bright marks in the background are a mix of stars, camera noise and streaks from small particles ejected from the comet.
Rosetta photo of Comet 67P/C-G.
1/4 MILE
Panorama by The New York Times

Feb. 14 On Valentine’s Day, Rosetta made its first close flyby of the comet, passing within four miles of the surface. Here the spacecraft looks down on the large depression at the top of the comet’s head.
Rosetta photo of Comet 67P/C-G.
500 FEET

Feb. 14 An image of the comet’s underbelly taken six miles above the surface during the Valentine’s Day flyby. The smooth plain in the foreground is called Imhotep.
Rosetta photo of Comet 67P/C-G.
1/2 MILE

Feb. 9 The comet is upside down in this image from 65 miles away, and a fan-shaped jet of dust streams from the comet’s neck region.
Rosetta photo of Comet 67P/C-G.
1/2 MILE

Feb. 6 Jets of gas and dust extend from the comet’s neck and other sunlit areas in this image taken from 77 miles away.
Rosetta photo of Comet 67P/C-G.
1/4 MILE

Feb. 3 This close-up image of the comet’s neck was taken from 18 miles away, and was the last image taken from orbit around Comet 67P/C-G. Rosetta will continue to follow the comet, but will leave its gravity-bound orbit because of increasing dust and instead begin a series of flybys.
Rosetta photo of Comet 67P/C-G.
1/4 MILE

Jan. 31 The comet’s head, neck and back are sunlit in this image taken from 17 miles away. A prominent jet of gas and dust extends from an active region of the surface near the comet’s neck.
Rosetta photo of Comet 67P/C-G.
1/4 MILE

Jan. 16 The tail of the comet’s larger lobe points up, revealing a smooth plain named Imhotep at left. Rosetta was 18 miles away when it took this image.
Rosetta photo of Comet 67P/C-G.
1/4 MILE

Jan. 3 The smooth plain named Imhotep, at center right, lies on the comet’s flat underbelly, seen here from a distance of about 18 miles.
Rosetta photo of Comet 67P/C-G.
1/4 MILE
Cheops
IMHOTEP

Dec. 14, 2014 The large triangular boulder on the flat Imhotep plain is named Cheops, after the Egyptian pyramid. The spacecraft was about 12 miles from the comet when it took this image.
Rosetta photo of Comet 67P/C-G.
1/4 MILE

Dec. 10 Sunlight falls between the body and head of the comet, lighting up a large group of boulders in the smooth Hapi region of the comet’s neck. To the right of the boulders, the cliffs of Hathor form the underside of the comet’s head. Rosetta took this image from a distance of 12 miles.
Rosetta photo of Comet 67P/C-G.
1/4 MILE

Dec. 2 The round depression in the middle of the comet’s head is filled with shadow in this image taken 12 miles above the comet.
Rosetta photo of Comet 67P/C-G.
1/4 MILE

Nov. 22 An overexposed image of Comet 67P/C-G from 19 miles away shows faint jets of gas and dust extending from the sunlit side of the comet.
Philae photo from the surface of Comet 67P/C-G.

Nov. 12 Rosetta’s washing-machine sized lander Philae successfully touched down on the comet’s head. But anchoring harpoons failed and Philae bounced twice before going missing in the shadow of a cliff or crater (above). Without sunlight Philae quickly lost power, but might revive as the comet gets closer to the sun. On March 12, Rosetta resumed listening for radio signals from the missing lander.
Rosetta photo of Comet 67P/C-G.

Photo illustration by The New York Times

How big is the comet? The body of Comet 67P/C-G is about as long as Central Park. For images of Rosetta’s rendezvous and the Philae landing, see Landing on a Comet, 317 Million Miles From Home.

Sources: European Space Agency and the Rosetta mission. Images by ESA/Rosetta, except where noted. Some images are composite panoramas created by ESA, and most images were processed by ESA to bring out details of the comet’s activity.

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If the Moon Landings Were Real, Then Why is NASA Stumped by This?

March 21, 2015 / / 0 Comments

Buck Rogers, Staff WriterWaking TimesDuring the cold war era the Soviet Union and the United States were locked in an arms and technology race, each nation wanting to prove their dominance over the other, each striving to be the next reigning superpower in a world still shattered by the second world war. The Soviet’s took the lead when in April of 1961, cosmonaut Yuri Gagarin successfully orbited the earth and returned home safely. In May, president John F. Kennedy ma [...]

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Biologists fear DNA editing procedure can alter human DNA

March 20, 2015 / / 0 Comments




Excerpt from themarketbusiness.com

A group of biologists was alarmed with the use a new genome-editing technique to modify human DNA in a way that it can become hereditary.
The biologists worry that the new technique is so effective and easy to use that some physicians may push ahead with it before its safety can be weigh up. They also want the public to understand the ethical issues surrounding the technique, which could be used to cure genetic diseases, but also to enhance qualities like beauty or intelligence. The latter is a path that many ethicists believe should never be taken.

“You could exert control over human heredity with this technique, and that is why we are raising the issue,” said David Baltimore, a former president of the California Institute of Technology and a member of the group whose paper on the topic was published in the journal Science.

Ethicists have been concerned for decades about the dangers of altering the human germ line — meaning to make changes to human sperm, eggs or embryos that will last through the life of the individual and be passed on to future generations. Until now, these worries have been theoretical. But a technique invented in 2012 makes it possible to edit the genome precisely and with much greater ease. The technique has already been used to edit the genomes of mice, rats and monkeys, and few doubt that it would work the same way in people.

The new genome-editing technique holds the power to repair or enhance any human gene. “It raises the most fundamental of issues about how we are going to view our humanity in the future and whether we are going to take the dramatic step of modifying our own germline and in a sense take control of our genetic destiny, which raises enormous peril for humanity,” said George Daley, a stem cell expert at Boston Children’s Hospital and a member of the group.

The biologists writing in Science support continuing laboratory research with the technique, and few if any scientists believe it is ready for clinical use. Any such use is tightly regulated in the United States and Europe. American scientists, for instance, would have to present a plan to treat genetic diseases in the human germline to the Food and Drug Administration.

The paper’s authors, however, are concerned about countries that have less regulation in science. They urge that “scientists should avoid even attempting, in lax jurisdictions, germ line genome modification for clinical application in humans” until the full implications “are discussed among scientific and governmental organizations.”

Though such a moratorium would not be legally enforceable and might seem unlikely to exert global sway, there is a precedent. In 1975, scientists worldwide were asked to refrain from using a method for manipulating genes, the recombinant DNA technique, until rules had been established.

“We asked at that time that nobody do certain experiments, and in fact nobody did, to my knowledge,” said Baltimore, who was a member of the 1975 group. “So there is a moral authority you can assert from the U.S., and that is what we hope to do.”

Recombinant DNA was the first in a series of ever-improving steps for manipulating genetic material. The chief problem has always been one of accuracy, of editing the DNA at precisely the intended site, since any off-target change could be lethal. Two recent methods, known as zinc fingers and TAL effectors, came close to the goal of accurate genome editing, but both are hard to use. The new genome-editing approach was invented by Jennifer Doudna of the University of California, Berkeley, and Emmanuelle Charpentier of Umea University in Sweden.

Their method, known by the acronym Crispr-Cas9, co-opts the natural immune system with which bacteria remember the DNA of the viruses that attack them so they are ready the next time those same invaders appear. Researchers can simply prime the defense system with a guide sequence of their choice and it will then destroy the matching DNA sequence in any genome presented to it. Doudna is the lead author of the Science article calling for control of the technique and organized the meeting at which the statement was developed.

Though highly efficient, the technique occasionally cuts the genome at unintended sites. The issue of how much mistargeting could be tolerated in a clinical setting is one that Doudna’s group wants to see thoroughly explored before any human genome is edited.

Scientists also say that replacing a defective gene with a normal one may seem entirely harmless but perhaps would not be.
“We worry about people making changes without the knowledge of what those changes mean in terms of the overall genome,” Baltimore said. “I personally think we are just not smart enough — and won’t be for a very long time — to feel comfortable about the consequences of changing heredity, even in a single individual.”
Many ethicists have accepted the idea of gene therapy, changes that die with the patient, but draw a clear line at altering the germline, since these will extend to future generations. The British Parliament in February approved the transfer of mitochondria, small DNA-containing organelles, to human eggs whose own mitochondria are defective. But that technique is less far-reaching because no genes are edited.

There are two broad schools of thought on modifying the human germline, said R. Alta Charo, a bioethicist at the University of Wisconsin and a member of the Doudna group. One is pragmatic and seeks to balance benefit and risk. The other “sets up inherent limits on how much humankind should alter nature,” she said. 
Some Christian doctrines oppose the idea of playing God, whereas in Judaism and Islam there is the notion “that humankind is supposed to improve the world.” She described herself as more of a pragmatist, saying, “I would try to regulate such things rather than shut a new technology down at its beginning.”

Other scientists agree with the Doudna group’s message.
“It is very clear that people will try to do gene editing in humans,” said Rudolf Jaenisch, a stem cell biologist at the Whitehead Institute in Cambridge, Massachusetts, who was not a member of the Doudna group. “This paper calls for a moratorium on any clinical application, which I believe is the right thing to do.”
Writing in Nature last week, Edward Lanphier and other scientists involved in developing the rival zinc finger technique for genome editing also called for a moratorium on human germline modification, saying that use of current technologies would be “dangerous and ethically unacceptable.”

The International Society for Stem Cell Research said Thursday that it supported the proposed moratorium.

The Doudna group calls for public discussion but is also working to develop some more formal process, such as an international meeting convened by the National Academy of Sciences, to establish guidelines for human use of the genome-editing technique.

“We need some principled agreement that we want to enhance humans in this way or we don’t,” Jaenisch said. “You have to have this discussion because people are gearing up to do this.”

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