Cobra in progress, Pandora in progress. L0 partial systemic collapse in 20.2, partial MASTERPIECE failure, EOSTRE attempt temp stable and then failed. Two drastic VTX security breaches, deflected. Potentially fatal PBS security breach, still in deflec...
Tag: sequences (page 1 of 3)
Pandora in progress, gamma grid ratio recovery in progress, EOSTRE on hold. PBS / VTX security breach deflection in progress. Wipeout sequences 1-2 complete. Minimum M requirements met, minimum DL / HP / SD / VTX requirements not met.
Pandora in progress, gamma grid ratio recovery in progress, EOSTRE on hold. PBS / VTX security breach deflection in progress. Wipeout sequences 1-2 complete. Minimum M requirements met, minimum DL / HP / SD / VTX requirements not met.
Pandora in progress, gamma grid ratio recovery failure, EOSTRE in progress. Potentially fatal PBS / VTX security breach at 504, recovery attempt in progress. Wipeout sequences 1-3 initialized. Minimum M requirements met, minimum DL / HP / SD / VTX req...
Cobra in progress, Pandora in progress, multiple EXMOSS / EELA / ZEOLITE sequences in progress, BIOCHIP layer removal in progress, U96 / TOPAZ activated, ATLANTIS12 clear. Several systems / Isidic security breaches, all deflected, HVBN unstable t...
A Failed War On Cancer Sayer Ji, Green Med InfoEver since Richard Nixon officially declared a war on cancer in 1971 through the signing of the National Cancer Act, over a hundred billion dollars of taxpayer money has been spent on research and drug development in an attempt to eradicate the disease, with trillions more spent by the cancer patients themselves, but with disappointing results.Even after four decades of waging full-scale “conventional” (s [...]
Excerpt from slashgear.com
A revolutionary method of editing the human genome has this week become the subject of a patent war. Back in April of 2014, patents were awarded by the USPTO (United States Patent and Trademark Office) to the Broad Institutes’ Dr. Feng Zhang, MIT, and Harvard to develop the technology behind "CRISPR-Cas9".
This April, the UC Board of Regents’ legal team spoke with the USPTO about reconsidering their action, suggesting they award the patent to the inventor of the original method, UC Berkeley’s Jennifer Doudna. One way or another, this radical DNA modifier must be made.
We need X-Men, after all.
The following video will explain what this genome-editing piece of technological breakthrough is all about. CRISPR-Cas9 is what it's called, and getting in to your body to make changes on a DNA level is what it's going for.
CRISPR-Cas9 works as a tiny scissors.
Utilizing the natural bacterial-level protective system used by your body to fight infections, CRISPR-Cas9 replicates the sequences of target DNA strands and latches on.
It's the connector that CRISPR-Cas9 makes real, and really programmable.
Your body provides the Cas9.* The Cas9 is the nuclease enzyme that cuts DNA strands.
*Correction - BACTERIA have Cas9, not our human selves. As helpful commenter "John" put so eloquently, "So far it has only been found in bacterial cells, and that's one of the things that makes it so amazing--a relatively simple molecular system that replicates many of the functions of our elaborate adaptive immune response, all in a single prokaryotic cell!"
When a DNA sequence is cut, it may attempt to re-form. In doing so, it can create mutations.
But that's a discussion for another day.
Genetically altered twin monkeys have been made using the CRISPR-Cas9 method. As you'll see in DOI: http://dx.doi.org/10.1016/j.cell.2014.01.027 in Cell Symposia "Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos", these monkeys are living large on gene-altered action.
Today what's important is that two groups are fighting for the patents involved in CRISPR-Cas9.
A paper published online June 28 2012 by Science authored by Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A. Doudna, and Emmanuelle Charpentier describes the method: "A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity."
You can find this paper under code DOI: 10.1126/science.1225829.
Dr. Zhang suggests he demonstrated the CRISPR genome editing method before the 2012 paper was published by Dr. Doudna and Dr. Charpentier and crew. Dr. Doudna and Dr. Charpentier and crew suggest say Dr. Zhang's notebook (used as proof for patents) does not prove genome editing before the 2012 paper was published.
Can't we all just get along? Think of the monkeys!
Click to zoom
Reuters
With the right expertise in molecular biology, one could start a basic laboratory to modify human embryos using a genome-editing computer technique all for a couple thousand dollars, according to a new report.
Genetic modification has received heightened scrutiny recently following last week’s announcement that Chinese researchers had, for the first time, successfully edited human embryos’ genomes.
The team at Sun Yat-Sen University in Guangzhou, China, used CRISPR (clustered regularly interspaced palindromic repeats), a technique that relies on “cellular machinery” used by bacteria in defense against viruses.
This machinery is copied and altered to create specific gene-editing complexes, which include the wonder enzyme Cas9. The enzyme works its way into the DNA and can be used to alter the molecule from the inside. The combination is attached to an RNA guide that takes the gene-editing complex to its target, telling Cas9 where to operate.
Use of the CRISPR technique is not necessarily relegated to the likes of cash-flush university research operations, according to a report by Business Insider.
"You could conceivably set up a CRISPR lab for $2,000,” he said, according to Business Insider.
Other top researchers have echoed this sentiment.
"Any scientist with molecular biology skills and knowledge of how to work with [embryos] is going to be able to do this,” Jennifer Doudna, a biologist at the University of California, Berkeley, recently told MIT Tech Review, which reported that Doudna co-discovered how to edit genetic code using CRISPR in 2012.
Last week, the Sun Yat-Sen University research team said it attempted to cure a gene defect that causes beta-thalassemia (a genetic blood disorder that could lead to severe anemia, poor growth, skeletal abnormalities and even death) by editing the germ line. For that purpose they used a gene-editing technique based on injecting non-viable embryos with a complex, which consists of a protective DNA element obtained from bacteria and a specific protein.
"I suspect this week will go down as a pivotal moment in the history of medicine," wrote science journalist Carl Zimmer for National Geographic.
Response to the new research has been mixed. Some experts say the gene editing could help defeat genetic diseases even before birth. Others expressed concern.
“At present, the potential safety and efficacy issues arising from the use of this technology must be thoroughly investigated and understood before any attempts at human engineering are sanctioned, if ever, for clinical testing,” a group of scientists, including some who had worked to develop CRISPR, warned in Science magazine.
Meanwhile, the director of the US National Institutes for Health (NIH) said the agency would not fund such editing of human embryo genes.
“Research using genomic editing technologies can and are being funded by NIH,” Francis Collins said Wednesday. “However, NIH will not fund any use of gene-editing technologies in human embryos. The concept of altering the human germline in embryos for clinical purposes ... has been viewed almost universally as a line that should not be crossed.”
Although the discovery of CRISPR sequences dates back to 1987 – when it was first used to cure bacteria of viruses – its successes in higher animals and humans were only achieved in 2012-13, when scientists achieved a revolution by combining the resulting treatment system with Cas9 for the first time.
On April 17, the MIT’s Broad Institute announced that has been awarded the first-ever patent for working with the Crisp-Cas9 system.
The institute’s director, Eric Lander, sees the combination as “an extraordinary, powerful tool. The ability to edit a genome makes it possible to discover the biological mechanisms underlying human biology.”
The system’s advantage over other methods is in that it can also target several genes at the same time, working its way through tens of thousands of so-called 'guide' RNA sequences that lead them to the weapon to its DNA targets.
Meanwhile, last month in the UK, a healthy baby was born from an embryo screened for genetic diseases, using karyomapping, a breakthrough testing method that allows doctors to identify about 60 debilitating hereditary disorders.
Originally Posted at in5d.com The following is the alleged result of the actions of one or more scientists creating a covert, unauthorized notebook documenting their involvement with an Above Top Secret government program. Government publications and information obtained by the use of public tax monies cannot be subject to copyright. This document is released into the public domain for all citizens of the United States of America. THE ‘MAJIC PROJECTS’ SIGMA is the project whic [...]
NASA's New Horizons space probe has successfully woken up from hibernation as it closes in on Pluto and its satellites.
Excerpt from csmonitor.com
NASA’s fastest space probe ever launched to the outer Solar System, New Horizons, has woken successfully from hibernation as it closes in on target Pluto.Mission controllers confirmed early today that the spacecraft had switched to active mode, in preparation for its fly past the former planet and its moons on 14 July, 2015.
It took four hours and 26 minutes for the signal to travel more than 2.9 billion miles (4.7 billion km) back to Earth to confirm that the probe was alive. It was picked up by NASA’s Deep Space Network station in Canberra, Australia.
After a nine year voyage, this is the farthest any space mission has traveled to reach its primary target.
Operators at the Johns Hopkins University Applied Physics Laboratory confirmed at 9:53 p.m. (EST) ) 02:53 (UTC) that New Horizons, had switched from hibernation to active mode, as its pre-programmed computer commands instructed.
Launched on January 19, 2006, New Horizons has spent about two-thirds of its flight time, 1,873 days, in hibernation.
During hibernation mode, much of the New Horizons spacecraft was unpowered. The onboard flight computer monitored system health and broadcast a weekly beacon-status tone back to Earth.
As part of the wake-up, NASA broadcast a special version of Where My Heart Will Take Me, by English tenor Russell Watson, which included a greeting to New Horizons from the singer.
The next few weeks will be used to check that the spacecraft's systems and science instruments are operating properly, and to build and test the computer-command sequences that will guide New Horizons through its flight to and reconnaissance of the Pluto system.
“New Horizons is on a journey to a new class of planets we’ve never seen, in a place we’ve never been before,” said New Horizons Project Scientist Hal Weaver, of APL. “For decades we thought Pluto was this odd little body on the planetary outskirts; now we know it’s really a gateway to an entire region of new worlds in the Kuiper Belt, and New Horizons is going to provide the first close-up look at them.”
Lance Schuttler, Personable MediaWe live in a world today where the idea of group power is being rekindled and where it’s momentum is gathering. Humanity as a whole is remembering that it is thoughts and actions of kindness, honesty and equality for all that create positive change.One initiative that is expanding throughout religious and spiritual groups, as well as on blogs and other social media sites is globally synchronized meditation/prayer gatherings.To some, believing that tho [...]
Contributed by Michael ForresterThe fascinating and recent discovery of a new, second DNA code further lends credence to what metaphysical scientists have been saying for millennia -- the body speaks two different languages.Since the genetic code was deciphered in the 1960s, researchers have assumed that it was used exclusively to write information about proteins.But biologists have suspected for years that some kind of epigenetic inheritance occurs at the cellular level. The different [...]
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