Reuters
With the right expertise in molecular biology, one could start a basic laboratory to modify human embryos using a genome-editing computer technique all for a couple thousand dollars, according to a new report.
Genetic modification has received heightened scrutiny recently following last week’s announcement that Chinese researchers had, for the first time, successfully edited human embryos’ genomes.
The team at Sun Yat-Sen University in Guangzhou, China, used CRISPR (clustered regularly interspaced palindromic repeats), a technique that relies on “cellular machinery” used by bacteria in defense against viruses.
This machinery is copied and altered to create specific gene-editing complexes, which include the wonder enzyme Cas9. The enzyme works its way into the DNA and can be used to alter the molecule from the inside. The combination is attached to an RNA guide that takes the gene-editing complex to its target, telling Cas9 where to operate.
Use of the CRISPR technique is not necessarily relegated to the likes of cash-flush university research operations, according to a report by Business Insider.
"You could conceivably set up a CRISPR lab for $2,000,” he said, according to Business Insider.
Other top researchers have echoed this sentiment.
"Any scientist with molecular biology skills and knowledge of how to work with [embryos] is going to be able to do this,” Jennifer Doudna, a biologist at the University of California, Berkeley, recently told MIT Tech Review, which reported that Doudna co-discovered how to edit genetic code using CRISPR in 2012.
Last week, the Sun Yat-Sen University research team said it attempted to cure a gene defect that causes beta-thalassemia (a genetic blood disorder that could lead to severe anemia, poor growth, skeletal abnormalities and even death) by editing the germ line. For that purpose they used a gene-editing technique based on injecting non-viable embryos with a complex, which consists of a protective DNA element obtained from bacteria and a specific protein.
"I suspect this week will go down as a pivotal moment in the history of medicine," wrote science journalist Carl Zimmer for National Geographic.
Response to the new research has been mixed. Some experts say the gene editing could help defeat genetic diseases even before birth. Others expressed concern.
“At present, the potential safety and efficacy issues arising from the use of this technology must be thoroughly investigated and understood before any attempts at human engineering are sanctioned, if ever, for clinical testing,” a group of scientists, including some who had worked to develop CRISPR, warned in Science magazine.
Meanwhile, the director of the US National Institutes for Health (NIH) said the agency would not fund such editing of human embryo genes.
“Research using genomic editing technologies can and are being funded by NIH,” Francis Collins said Wednesday. “However, NIH will not fund any use of gene-editing technologies in human embryos. The concept of altering the human germline in embryos for clinical purposes ... has been viewed almost universally as a line that should not be crossed.”
Although the discovery of CRISPR sequences dates back to 1987 – when it was first used to cure bacteria of viruses – its successes in higher animals and humans were only achieved in 2012-13, when scientists achieved a revolution by combining the resulting treatment system with Cas9 for the first time.
On April 17, the MIT’s Broad Institute announced that has been awarded the first-ever patent for working with the Crisp-Cas9 system.
The institute’s director, Eric Lander, sees the combination as “an extraordinary, powerful tool. The ability to edit a genome makes it possible to discover the biological mechanisms underlying human biology.”
The system’s advantage over other methods is in that it can also target several genes at the same time, working its way through tens of thousands of so-called 'guide' RNA sequences that lead them to the weapon to its DNA targets.
Meanwhile, last month in the UK, a healthy baby was born from an embryo screened for genetic diseases, using karyomapping, a breakthrough testing method that allows doctors to identify about 60 debilitating hereditary disorders.
Google Chairman Eric Schmidt: "The Internet Will Disappear"
Excerpt from hollywoodreporter.com
Google executive chairman Eric Schmidt on Thursday predicted the end of the Internet as we know it.
At the end of a panel at the World Economic Forum in Davos, Switzerland, where his comments were webcast, he was asked for his prediction on the future of the web. “I will answer very simply that the Internet will disappear,” Schmidt said.
“There will be so many IP addresses…so many devices, sensors, things that you are wearing, things that you are interacting with that you won’t even sense it,” he explained. “It will be part of your presence all the time. Imagine you walk into a room, and the room is dynamic. And with your permission and all of that, you are interacting with the things going on in the room.”
Concluded Schmidt: “A highly personalized, highly interactive and very, very interesting world emerges.”
The panel, entitled The Future of the Digital Economy, also featured Facebook COO Sheryl Sandberg and others.
Earlier in the debate, Schmidt discussed the issue of market dominance. The European Union has been looking at Google’s search market dominance in a long-running antitrust case, and the European parliament late last year even called for a breakup.
Asked about his recent trip to North Korea, Schmidt said the country has many Internet connections through data phones, but there is no roaming and web usage is “heavily supervised.” Schmidt said “it’s very much surveillance of use,” which he said was not good for the country and others.
Sandberg and Schmidt lauded the Internet as an important way to give more people in the world a voice. Currently, only 40 percent of people have Internet access, the Facebook COO said, adding that any growth in reach helps extend people’s voice and increase economic opportunity. “I’m a huge optimist,” she said about her outlook for the industry. “Imagine what we can do” once the world gets to 50 percent, 60 percent and more in terms of Internet penetration.
Schmidt similarly said that broadband can address governance issues, information needs, personal issues, women empowerment needs and education issues. “The Internet is the greatest empowerment of citizens … in many years,” he said. “Suddenly citizens have a voice, they can be heard.”
During another technology panel at the World Economic Forum on Thursday, Yahoo CEO Marissa Mayer, Liberty Global CEO Mike Fries and others answered questions on the need to regulate privacy standards on the Internet and for tech companies following the Snowden case, the Sony hack and the like.
Mayer said that the personalized Internet “is a better Internet,” emphasizing: “We don’t sell your personal data … We don’t transfer your personal data to third parties.” She said users own their data and need to have control, adding that people give up data to the government for tax assessment, social services and other purposes.
Both executives said transparency was important to make sure users know privacy standards and the like.
Gunther Oettinger, a conservative German politician serving as the European Union’s commissioner for digital economy and society, said on the panel that “we need a convincing global understanding, we need a UN agency for data protection and security.” Asked what form that “understanding” should have, he said he was looking for “clear, pragmatic, market-based regulation.” Explained Oettinger: “It’s a public-private partnership.”
Fries said such a solution was likely not to happen in the near term, given the size of the EU. “I think it is going to take several years,” he said, adding that some countries’ parliaments would likely take a stab at it.
But he warned that a joint solution would make more sense. “We don’t want Germany to have its own Internet,” Fries said. “Some countries may build their own Internets” and “balkanize” the web, he warned.
Mayer said on the issue of regulation: “I like Tim’s idea better of the beneficent marketplace.” She spoke of fellow panelist and computer specialist Tim Berners-Lee, known as the inventor of the World Wide Web.
Asked how Yahoo stores and handles client records, she said the online giant “changed the way we store and communicate data” after Snowden and also changed encryptions between data centers. And the company protects users through encryption methods, she added. Mayer said that trust and confidence of Yahoo users has rebounded since.
Mayer was also asked what happens if a government asks for a user’s data, a question that has new significance after the recent terrorist attacks in Paris, which have led some to call for increased surveillance powers of the Internet for governments. Mayer said Yahoo always assesses if such a request is reasonable. “We have a very good track record for standing up to what’s not reasonable,” she said.
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