Tag: MIT (page 1 of 2)

CRISPR-Cas9 modifies your DNA, under legal fire ~ Video




Excerpt from slashgear.com

A revolutionary method of editing the human genome has this week become the subject of a patent war. Back in April of 2014, patents were awarded by the USPTO (United States Patent and Trademark Office) to the Broad Institutes’ Dr. Feng Zhang, MIT, and Harvard to develop the technology behind "CRISPR-Cas9". 
This April, the UC Board of Regents’ legal team spoke with the USPTO about reconsidering their action, suggesting they award the patent to the inventor of the original method, UC Berkeley’s Jennifer Doudna. One way or another, this radical DNA modifier must be made. 

We need X-Men, after all.


The following video will explain what this genome-editing piece of technological breakthrough is all about. CRISPR-Cas9 is what it's called, and getting in to your body to make changes on a DNA level is what it's going for.

CRISPR-Cas9 works as a tiny scissors.

Utilizing the natural bacterial-level protective system used by your body to fight infections, CRISPR-Cas9 replicates the sequences of target DNA strands and latches on.

It's the connector that CRISPR-Cas9 makes real, and really programmable.

Your body provides the Cas9.* The Cas9 is the nuclease enzyme that cuts DNA strands.

*Correction - BACTERIA have Cas9, not our human selves. As helpful commenter "John" put so eloquently, "So far it has only been found in bacterial cells, and that's one of the things that makes it so amazing--a relatively simple molecular system that replicates many of the functions of our elaborate adaptive immune response, all in a single prokaryotic cell!"

Screen Shot 2015-05-15 at 10.11.42 AM
ABOVE: Image comes via Nature; Addgene, By Jonathan Corum, via NYT.

When a DNA sequence is cut, it may attempt to re-form. In doing so, it can create mutations.

But that's a discussion for another day.

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Genetically altered twin monkeys have been made using the CRISPR-Cas9 method. As you'll see in DOI: http://dx.doi.org/10.1016/j.cell.2014.01.027 in Cell Symposia "Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos", these monkeys are living large on gene-altered action.

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Today what's important is that two groups are fighting for the patents involved in CRISPR-Cas9.

A paper published online June 28 2012 by Science authored by Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A. Doudna, and Emmanuelle Charpentier describes the method: "A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity."

You can find this paper under code DOI: 10.1126/science.1225829.

Dr. Zhang suggests he demonstrated the CRISPR genome editing method before the 2012 paper was published by Dr. Doudna and Dr. Charpentier and crew. Dr. Doudna and Dr. Charpentier and crew suggest say Dr. Zhang's notebook (used as proof for patents) does not prove genome editing before the 2012 paper was published.

Can't we all just get along? Think of the monkeys!

Click to zoom

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The Class-Domination Theory of Power

by G. William DomhoffNOTE: WhoRulesAmerica.net is largely based on my book,Who Rules America?, first published in 1967 and now in its7th edition. This on-line document is presented as a summary of some of the main ideas in that book.Who has predominant power in the United States? The short answer, from 1776 to the present, is: Those who have the money -- or more specifically, who own income-producing land and businesses -- have the power. George Washington was one of the biggest landowner [...]

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Lab for genetic modification of human embryos just $2,000 away – report


Reuters / Christian Charisius



Reuters

With the right expertise in molecular biology, one could start a basic laboratory to modify human embryos using a genome-editing computer technique all for a couple thousand dollars, according to a new report.

Genetic modification has received heightened scrutiny recently following last week’s announcement that Chinese researchers had, for the first time, successfully edited human embryos’ genomes. 
The team at Sun Yat-Sen University in Guangzhou, China, used CRISPR (clustered regularly interspaced palindromic repeats), a technique that relies on “cellular machinery” used by bacteria in defense against viruses. 

This machinery is copied and altered to create specific gene-editing complexes, which include the wonder enzyme Cas9. The enzyme works its way into the DNA and can be used to alter the molecule from the inside. The combination is attached to an RNA guide that takes the gene-editing complex to its target, telling Cas9 where to operate. 

Use of the CRISPR technique is not necessarily relegated to the likes of cash-flush university research operations, according to a report by Business Insider. 


Geneticist George Church, who runs a top CRISPR research program at the Harvard Medical School, said the technique could be employed with expert knowledge and about half of the money needed to pay for an average annual federal healthcare plan in 2014 -- not to mention access to human embryos. 

"You could conceivably set up a CRISPR lab for $2,000,” he said, according to Business Insider. 

Other top researchers have echoed this sentiment. 

"Any scientist with molecular biology skills and knowledge of how to work with [embryos] is going to be able to do this,” Jennifer Doudna, a biologist at the University of California, Berkeley, recently told MIT Tech Review, which reported that Doudna co-discovered how to edit genetic code using CRISPR in 2012. 

Last week, the Sun Yat-Sen University research team said it attempted to cure a gene defect that causes beta-thalassemia (a genetic blood disorder that could lead to severe anemia, poor growth, skeletal abnormalities and even death) by editing the germ line. For that purpose they used a gene-editing technique based on injecting non-viable embryos with a complex, which consists of a protective DNA element obtained from bacteria and a specific protein. 

"I suspect this week will go down as a pivotal moment in the history of medicine," wrote science journalist Carl Zimmer for National Geographic.


Response to the new research has been mixed. Some experts say the gene editing could help defeat genetic diseases even before birth. Others expressed concern. 

“At present, the potential safety and efficacy issues arising from the use of this technology must be thoroughly investigated and understood before any attempts at human engineering are sanctioned, if ever, for clinical testing,” a group of scientists, including some who had worked to develop CRISPR, warned in Science magazine. 

Meanwhile, the director of the US National Institutes for Health (NIH) said the agency would not fund such editing of human embryo genes. 

“Research using genomic editing technologies can and are being funded by NIH,” Francis Collins said Wednesday. “However, NIH will not fund any use of gene-editing technologies in human embryos. The concept of altering the human germline in embryos for clinical purposes ... has been viewed almost universally as a line that should not be crossed.”

Although the discovery of CRISPR sequences dates back to 1987 – when it was first used to cure bacteria of viruses – its successes in higher animals and humans were only achieved in 2012-13, when scientists achieved a revolution by combining the resulting treatment system with Cas9 for the first time. 


On April 17, the MIT’s Broad Institute announced that has been awarded the first-ever patent for working with the Crisp-Cas9 system. 

The institute’s director, Eric Lander, sees the combination as “an extraordinary, powerful tool. The ability to edit a genome makes it possible to discover the biological mechanisms underlying human biology.”

The system’s advantage over other methods is in that it can also target several genes at the same time, working its way through tens of thousands of so-called 'guide' RNA sequences that lead them to the weapon to its DNA targets. 

Meanwhile, last month in the UK, a healthy baby was born from an embryo screened for genetic diseases, using karyomapping, a breakthrough testing method that allows doctors to identify about 60 debilitating hereditary disorders.

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Bees Do It, Humans Do It ~ Bees can experience false memories, scientists say



Excerpt from csmonitor.com


Researchers at Queen Mary University of London have found the first evidence of false memories in non-human animals.

It has long been known that humans – even those of us who aren't famous news anchors – tend to recall events that did not actually occur. The same is likely true for mice: In 2013, scientists at MIT induced false memories of trauma in mice, and the following year, they used light to manipulate mice brains to turn painful memories into pleasant ones.

Now, researchers at Queen Mary University of London have shown for the first time that insects, too, can create false memories. Using a classic Pavlovian experiment, co-authors Kathryn Hunt and Lars Chittka determined that bumblebees sometimes combine the details of past memories to form new ones. Their findings were published today in Current Biology.
“I suspect the phenomenon may be widespread in the animal kingdom," Dr. Chittka said in a written statement to the Monitor.
First, Chittka and Dr. Hunt trained their buzzing subjects to expect a reward if they visited two artificial flowers – one solid yellow, the other with black-and-white rings. The order didn’t matter, so long as the bee visited both flowers. In later tests, they would present a choice of the original two flower types, plus one new one. The third type was a combination of the first two, featuring yellow-and-white rings. At first, the bees consistently selected the original two flowers, the ones that offered a reward.

But a good night’s sleep seemed to change all that. One to three days after training, the bees became confused and started incorrectly choosing the yellow-and-white flower (up to fifty percent of the time). They seemed to associate that pattern with a reward, despite having never actually seen it before. In other words, the bumblebees combined the memories of two previous stimuli to generate a new, false memory.

“Bees might, on occasion, form merged memories of flower patterns visited in the past,” Chittka said. “Should a bee unexpectedly encounter real flowers that match these false memories, they might experience a kind of deja-vu and visit these flowers expecting a rich reward.”

Bees have a rather limited brain capacity, Chittka says, so it’s probably useful for them to “economize” by storing generalized memories instead of minute details.

“In bees, for example, the ability to learn more than one flower type is certainly useful,” Chittka said, “as is the ability to extract commonalities of multiple flower patterns. But this very ability might come at the cost of bees merging memories from multiple sequential experiences.”

Chittka has studied memory in bumblebees for two decades. Bees can be raised and kept in a lab setting, so they make excellent long-term test subjects.

“They are [also] exceptionally clever animals that can memorize the colors, patterns, and scents of multiple flower species – as well as navigate efficiently over long distances,” Chittka said.

In past studies, it was assumed that animals that failed to perform learned tasks had either forgotten them or hadn’t really learned them in the first place. Chittka’s research seems to show that animal memory mechanisms are much more elaborate – at least when it comes to bumblebees.

“I think we need to move beyond understanding animal memory as either storing or not storing stimuli or episodes,” Chittka said. “The contents of memory are dynamic. It is clear from studies on human memory that they do not just fade over time, but can also change and integrate with other memories to form new information. The same is likely to be the case in many animals.”

Chittka hopes this study will lead to a greater biological understanding of false memories – in animals and humans alike. He says that false memories aren’t really a “bug in the system,” but a side effect of complex brains that strive to learn the big picture and to prepare for new experiences.

“Errors in human memory range from misremembering minor details of events to generating illusory memories of entire episodes,” Chittka said. “These inaccuracies have wide-ranging implications in crime witness accounts and in the courtroom, but I believe that – like the quirks of information processing that occur in well known optical illusions – they really are the byproduct of otherwise adaptive processes.”

“The ability to memorize the overarching principles of a number of different events might help us respond in previously un-encountered situations,” Chittka added. “But these abilities might come at the expense of remembering every detail correctly.”
So, if generating false memories goes hand in hand with having a nervous system, does all this leave Brian Williams off the hook?

“It is possible that he conflated the memories,” Chittka said, “depending on his individual vulnerability to witnessing a traumatic event, plus a possible susceptibility to false memories – there is substantial inter-person variation with respect to this. It is equally possible that he was just ‘showing off’ when reporting the incident, and is now resorting to a simple lie to try to escape embarrassment. That is impossible for me to diagnose.”

But if Mr. Williams genuinely did misremember his would-be brush with death, Chittka says he shouldn’t be vilified.

“You cannot morally condemn someone for reporting something they think really did happen to them,” Chittka said. “You cannot blame an Alzheimer patient for forgetting to blow out the candle, even if they burn down the house as a result. In the same way, you can't blame someone who misremembers a crime as a result of false memory processes."

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Mars One mission cuts candidate pool down to 100 aspiring colonists

Excerpt from mashable.comOnly 100 people are still competing for four seats on a one-way trip to Mars advertised by Dutch nonprofit Mars One.In its latest round of cuts, the foundation cut its applicant pool from 660 to 100 finalists on Tuesday. More ...

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6 Supermaterials That Could Change Our World


Graphene

Excerpt from gizmodo.com

Graphene isn't the only game-changing material to come out of a lab. From aerogels nearly as light as air to metamaterials that manipulate light, here are six supermaterials that have the potential to transform the world of the future.

Self-healing Materials — Bioinspired Plastics

6 Supermaterials That Could Change Our World 
Self-healing plastic. Image credit: UIUC


The human body is very good at fixing itself. The built environment is not. Scott White at the University of Illinois at Urbana Champlain has been engineering bioinspired plastics that can self-heal. Last year, White's lab created a new polymer that oozes to repair a visible hole. The polymer is embedded with a vascular system of liquids that when broken and combined, clot just like blood. While other materials have been able to heal microscopic cracks, this new one repaired a hole 4 millimeter wide with cracks radiating all around it. Not big deal for a human skin, but a pretty big deal for plastic.

Engineers have also been envisioning concrete, asphalt, and metal that can heal themselves. (Imagine a city with no more potholes!) The rub, of course, lies in making them cheap enough to actually use, which is why the first applications for self-healing materials are most likely to be in space or in remote areas on Earth. 

Thermoelectric Materials — Heat Scavengers

6 Supermaterials That Could Change Our World 
Power blocks with thermoelectric material sued inside Alphabet Energy 's generator. Image credit: Alphabet Energy


If you've ever had a laptop burn up in your lap or touched the hot hood of car, then you've felt evidence of waste. Waste heat is the inevitable effect of running any that device that uses power. One estimate puts the amount of waste heat as two-thirds of all energy used. But what if there was a way to capture all that wasted energy? The answer to that "what if" is thermoelectric materials, which makes electricity from a temperature gradient.

Last year, California-based Alphabet Energy introduced a thermoelectric generator that plugs right into the exhaust pipe of ordinary generator, turning waste heat back into useful electricity. Alphabet Energy's generator uses a relatively cheap and naturally occurring thermoelectric material called tetrahedrite. Alphabet Energy says tetrahedrite can reach 5 to 10 percent efficiency.
Back in the lab, scientists have also been tinkering with another promising and possibly even more efficient thermoelectric material called skutterudite, which is a type of mineral that contains cobalt. Thermoelectric materials have already had niche applications—like on spacecraft—but skutterudite could get cheap and efficient enough to be wrapped around the exhaust pipes of cars or fridges or any other power-hogging machine you can think of. [Nature, MIT Technology Review, New Scientist]

Perovskites — Cheap Solar Cells

6 Supermaterials That Could Change Our World 
Solar cells made of perovskites. Image credit: University of Oxford


The biggest hurdle in moving toward renewable energy is, as these things always are, money. Solar power is getting ever cheaper, but making a plant's worth of solar cells from crystalline silicon is still an expensive, energy-intensive process. There's an alternative material that has the solar world buzzing though, and that's perovskites. 

Perovskites were first discovered over a century ago, but scientists are only just realizing its potential. In 2009, solar cells made from perovskites had a solar energy conversion efficiency of a measly 3.8 percent. In 2014, the number had leapt to 19.3 percent. That may not seem like much compared to traditional crystalline silicon cells with efficiencies hovering around 20 percent, but there's two other crucial points to consider: 1) perovskites have made such leaps and bounds in efficiency in just a few years that scientist think it can get even better and 2) perovskites are much, much cheaper. 

Perovskites are a class of materials defined by a particular crystalline structure. They can contain any number of elements, usually lead and tin for perovskites used in solar cells. These raw materials are cheap compared to crystalline silicon, and they can be sprayed onto glass rather than meticulously assembled in clean rooms. Oxford Photovoltaics is one of the leading companies trying to commercialize perovskites, which as wonderful as they have been in the lab, still do need to hold up in the real world. [WSJ, IEEE Spectrum, Chemical & Engineering News, Nature Materials]

Aerogels — Superlight and Strong

6 Supermaterials That Could Change Our World 
Image credit: NASA

Aerogels look like they should not be real. Although ghostly and ethereal, they can easily withstand the heat of a blowtorch and the weight of a car. The material is almost what exactly the name implies: gels where where the liquid has been replaced entirely by air. But you can see why it's also been called "frozen smoke" or "blue smoke." The actual matrix of an aerogel can be made of any number of substances, including silica, metal oxides, and, yes, also graphene. But the fact that aerogel is actually mostly made of air means that it's an excellent insulator (see: blowtorch). Its structure also makes it incredibly strong (see: car).

Aerogels do have one fatal flaw though: brittleness, especially when made from silica. But NASA scientists have been experimenting with flexible aerogels made of polymers to use insulators for spacecraft burning through the atmosphere. Mixing other compounds into even silica-based aerogels could make them more flexible. Add that to aerogel's lightness, strength, and insulating qualities, and that's one incredible material. [New Scientist, Gizmodo]

Metamaterials — Light Manipulators

If you've heard of metamaterials, you likely heard about it in a sentence that also mentioned "Harry Potter" and "invisibility cloak." And indeed, metamaterials, whose nanostructures are design to scatter light in specific ways, could possibly one day be used to render objects invisible—though it still probably wouldn't be as magical as Harry Potter's invisibility cloak. 

What's more interesting about metamaterials is that they don't just redirect visible light. Depending on how and what a particular metamaterial is made of, it can also scatter microwaves, radiowaves, or the little-known T-rays, which are between microwaves and infrared light on the electromagnetic spectrum. Any piece of electromagnetic spectrum could be manipulated by metamaterials. 

That could be, for example, new T-ray scanners in medicine or security or a compact radio antennae made of metamaterials whose properties change on the fly. Metamaterials are at the promising but frustrating cusp where the theoretical possibilities are endless, but commercialization is still a long, hard road. [Nature, Discover Magazine]

Stanene — 100 percent efficient conductor

6 Supermaterials That Could Change Our World 
The molecular structure of stanene. Image credit: SLAC


Like the much better known graphene, stanene is also made of a single layer of atoms. But instead of carbon, stanene is made of tin, and this makes all the difference in allowing stanene to possibly do what even wondermaterial extraordinaire graphene cannot: conduct electricity with 100 percent efficiency.

Stanene was first theorized in 2013 by Stanford professor Shoucheng Zhang, whose lab specializes in, along other things, predicting the electronic properties of materials like stanene. According to their models, stanene is a topological insulator, which means its edges are a conductor and its inside is an insulator. (Think of a chocolate-covered ice cream bar. Chocolate conductor, ice cream insulator.) 

This means stanene could conduct electricity with zero resistance even, crucially, at room temperature. Stanene's properties have yet to been tested experimentally—making a single-atom sheet tin is no easy task—but several of Zhang's predictions about other topological insulators have proven correct.

If the predictions about stanene bear out, it could revolutionize the microchips inside all your devices. Namely, the chips could get a lot more powerful. Silicon chips are limited by the heat created by electrons zipping around—work 'em too fast and they'll simply get too hot. Stanene, which conducts electricity 100 percent efficiency, would have no such problem. [SLAC, Physical Review Letters, Scientific American]

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Study finally answers why it smells so good after it rains

Excerpt from usatoday.comIt turns out tiny bubbles may be to thank for that earthy smell we get after it rains, according to a study from researchers at the Massachusetts Institute of Technology.Youngsoo Joung and Cullen R. Buie used high-speed came...

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Chondrules Were Byproducts of Violent Planetary Process


 Chondrules were Byproducts of Violent Planetary Process



Excerpt from perfscience.com

For long, meteors that crashed on earth were considered to be remnants of the early solar system. The meteors are usually found studded with chondrules, tiny, glass, spherical grains.  It was considered that chondrules were early kernels of terrestrial planets.

But researchers at MIT and Purdue University have a new revelation to make. They have found that chondrules might not have played a fundamental role in the formation of planets.  The researchers based their findings on computer simulations and concluded that chondrules are by-products of planetary process and not the building blocks. The team found that planetary bodies as big as moon already existed before chondrules came on the scene. 

The researchers think that chondrules were most probably formed by the collision of moon-sized planter embryos. Brandon Johnson from MIT’s Department of Earth, Atmospheric and Planetary Sciences said, “This tells us that meteorites aren’t actually representative of the material that formed planets — they’re these smaller fractions of material that are the byproduct of planet formation”.  Johnson affirmed that the study findings have also unveiled that the early solar system was more violent than they have expected. The research team said that they have also modeled all the different types of impact that might have taken place in the early solar system.
For long, meteors that crashed on earth were considered to be remnants of the early solar system. The meteors are usually found studded with chondrules, tiny, glass, spherical grains.
It was considered that chondrules were early kernels of terrestrial planets. But researchers at MIT and Purdue University have a new revelation to make. They have found that chondrules might not have played a fundamental role in the formation of planets.
The researchers based their findings on computer simulations and concluded that chondrules are by-products of planetary process and not the building blocks. The team found that planetary bodies as big as moon already existed before chondrules came on the scene.
The researchers think that chondrules were most probably formed by the collision of moon-sized planter embryos. Brandon Johnson from MIT’s Department of Earth, Atmospheric and Planetary Sciences said, “This tells us that meteorites aren’t actually representative of the material that formed planets — they’re these smaller fractions of material that are the byproduct of planet formation”.
Johnson affirmed that the study findings have also unveiled that the early solar system was more violent than they have expected. The research team said that they have also modeled all the different types of impact that might have taken place in the early solar system.
- See more at: http://perfscience.com/content/2141073-chondrules-were-byproducts-violent-planetary-process#sthash.4XzOzvJT.dpuf
For long, meteors that crashed on earth were considered to be remnants of the early solar system. The meteors are usually found studded with chondrules, tiny, glass, spherical grains.
It was considered that chondrules were early kernels of terrestrial planets. But researchers at MIT and Purdue University have a new revelation to make. They have found that chondrules might not have played a fundamental role in the formation of planets.
The researchers based their findings on computer simulations and concluded that chondrules are by-products of planetary process and not the building blocks. The team found that planetary bodies as big as moon already existed before chondrules came on the scene.
The researchers think that chondrules were most probably formed by the collision of moon-sized planter embryos. Brandon Johnson from MIT’s Department of Earth, Atmospheric and Planetary Sciences said, “This tells us that meteorites aren’t actually representative of the material that formed planets — they’re these smaller fractions of material that are the byproduct of planet formation”.
Johnson affirmed that the study findings have also unveiled that the early solar system was more violent than they have expected. The research team said that they have also modeled all the different types of impact that might have taken place in the early solar system.
- See more at: http://perfscience.com/content/2141073-chondrules-were-byproducts-violent-planetary-process#sthash.4XzOzvJT.dpuf

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Meteorites may have been given too much credit for ‘building’ our Solar System





Excerpt from thespacereporter.com


Meteorites might not have had as much of an impact as early planet formation as we thought.The space rocks are commonly considered to be the building blocks of planets, but a new study by MIT and Purdue scientists suggests that the rocks are merely a byproduct of planet formation, not a crucial part in the process.

According to the study, meteorites are what was cast off when other proto-planetary bodies collided in the early days of the Solar System. The new theory, which was determined using computer simulations of collisions in the early Solar System, counteracts the theory that meteorites’ chondrules (small grains of molten droplets on their surface) are remnants of collisions with gas and dust that eventually formed planets.

“This tells us that meteorites aren’t actually representative of the material that formed planets – they’re these smaller fractions of material that are the byproduct of planet formation,” says Brandon Johnson of MIT’s Earth, Atmospheric and Planetary Sciences department. “But it also tells us the early solar system was more violent than we expected: You had these massive sprays of molten material getting ejected out from these really big impacts. It’s an extreme process.”

The collision models showed that bodies the size of the Moon formed well before meteorites would have formed chondrules, suggesting that the meteorites were not involved in building planets in the previously accepted manner.

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The Future of Technology in 2015?




Excerpt from
cnet.com


The year gone by brought us more robots, worries about artificial intelligence, and difficult lessons on space travel. The big question: where's it all taking us?

Every year, we capture a little bit more of the future -- and yet the future insists on staying ever out of reach.
Consider space travel. Humans have been traveling beyond the atmosphere for more than 50 years now -- but aside from a few overnights on the moon four decades ago, we have yet to venture beyond low Earth orbit.
Or robots. They help build our cars and clean our kitchen floors, but no one would mistake a Kuka or a Roomba for the replicants in "Blade Runner." Siri, Cortana and Alexa, meanwhile, are bringing some personality to the gadgets in our pockets and our houses. Still, that's a long way from HAL or that lad David from the movie "A.I. Artificial Intelligence."
Self-driving cars? Still in low gear, and carrying some bureaucratic baggage that prevents them from ditching certain technology of yesteryear, like steering wheels.
And even when these sci-fi things arrive, will we embrace them? A Pew study earlier this year found that Americans are decidedly undecided. Among the poll respondents, 48 percent said they would like to take a ride in a driverless car, but 50 percent would not. And only 3 percent said they would like to own one.
"Despite their general optimism about the long-term impact of technological change," Aaron Smith of the Pew Research Center wrote in the report, "Americans express significant reservations about some of these potentially short-term developments" such as US airspace being opened to personal drones, robot caregivers for the elderly or wearable or implantable computing devices that would feed them information.
Let's take a look at how much of the future we grasped in 2014 and what we could gain in 2015.

Space travel: 'Space flight is hard'

In 2014, earthlings scored an unprecedented achievement in space exploration when the European Space Agency landed a spacecraft on a speeding comet, with the potential to learn more about the origins of life. No, Bruce Willis wasn't aboard. Nobody was. But when the 220-pound Philae lander, carried to its destination by the Rosetta orbiter, touched down on comet 67P/Churyumov-Gerasimenko on November 12, some 300 million miles from Earth, the celebration was well-earned.
A shadow quickly fell on the jubilation, however. Philae could not stick its first landing, bouncing into a darker corner of the comet where its solar panels would not receive enough sunlight to charge the lander's batteries. After two days and just a handful of initial readings sent home, it shut down. For good? Backers have allowed for a ray of hope as the comet passes closer to the sun in 2015. "I think within the team there is no doubt that [Philae] will wake up," lead lander scientist Jean-Pierre Bibring said in December. "And the question is OK, in what shape? My suspicion is we'll be in good shape."
The trip for NASA's New Horizons spacecraft has been much longer: 3 billion miles, all the way to Pluto and the edge of the solar system. Almost nine years after it left Earth, New Horizons in early December came out of hibernation to begin its mission: to explore "a new class of planets we've never seen, in a place we've never been before," said project scientist Hal Weaver. In January, it will begin taking photos and readings of Pluto, and by mid-July, when it swoops closest to Pluto, it will have sent back detailed information about the dwarf planet and its moon, en route to even deeper space.


Also in December, NASA made a first test spaceflight of its Orion capsule on a quick morning jaunt out and back, to just over 3,600 miles above Earth (or approximately 15 times higher than the International Space Station). The distance was trivial compared to those those traveled by Rosetta and New Horizons, and crewed missions won't begin till 2021, but the ambitions are great -- in the 2030s, Orion is expected to carry humans to Mars.
In late March 2015, two humans will head to the ISS to take up residence for a full year, in what would be a record sleepover in orbit. "If a mission to Mars is going to take a three-year round trip," said NASA astronaut Scott Kelly, who will be joined in the effort by Russia's Mikhail Kornienko, "we need to know better how our body and our physiology performs over durations longer than what we've previously on the space station investigated, which is six months."
There were more sobering moments, too, in 2014. In October, Virgin Galactic's sleek, experimental SpaceShipTwo, designed to carry deep-pocketed tourists into space, crashed in the Mojave Desert during a test flight, killing one test pilot and injuring the other. Virgin founder Richard Branson had hoped his vessel would make its first commercial flight by the end of this year or in early 2015, and what comes next remains to be seen. Branson, though, expressed optimism: "Space flight is hard -- but worth it," he said in a blog post shortly after the crash, and in a press conference, he vowed "We'll learn from this, and move forward together." Virgin Galactic could begin testing its next spaceship as soon as early 2015.
The crash of SpaceShipTwo came just a few days after the explosion of an Orbital Sciences rocket lofting an unmanned spacecraft with supplies bound for the International Space Station. And in July, Elon Musk's SpaceX had suffered the loss of one of its Falcon 9 rockets during a test flight. Musk intoned, via Twitter, that "rockets are tricky..."
Still, it was on the whole a good year for SpaceX. In May, it unveiled its first manned spacecraft, the Dragon V2, intended for trips to and from the space station, and in September, it won a $2.6 billion contract from NASA to become one of the first private companies (the other being Boeing) to ferry astronauts to the ISS, beginning as early as 2017. Oh, and SpaceX also has plans to launch microsatellites to establish low-cost Internet service around the globe, saying in November to expect an announcement about that in two to three months -- that is, early in 2015.
One more thing to watch for next year: another launch of the super-secret X-37B space place to do whatever it does during its marathon trips into orbit. The third spaceflight of an X-37B -- a robotic vehicle that, at 29 feet in length, looks like a miniature space shuttle -- ended in October after an astonishing 22 months circling the Earth, conducting "on-orbit experiments."

Self-driving cars: Asleep at what wheel?

Spacecraft aren't the only vehicles capable of autonomous travel -- increasingly, cars are, too. Automakers are toiling toward self-driving cars, and Elon Musk -- whose name comes up again and again when we talk about the near horizon for sci-fi tech -- says we're less than a decade away from capturing that aspect of the future. In October, speaking in his guise as founder of Tesla Motors, Musk said: "Like maybe five or six years from now I think we'll be able to achieve true autonomous driving where you could literally get in the car, go to sleep and wake up at your destination." (He also allowed that we should tack on a few years after that before government regulators give that technology their blessing.)
Prototype, unbound: Google's ride of the future, as it looks today Google
That comment came as Musk unveiled a new autopilot feature -- characterizing it as a sort of super cruise control, rather than actual autonomy -- for Tesla's existing line of electric cars. Every Model S manufactured since late September includes new sensor hardware to enable those autopilot capabilities (such as adaptive cruise control, lane-keeping assistance and automated parking), to be followed by an over-the-air software update to enable those features.
Google has long been working on its own robo-cars, and until this year, that meant taking existing models -- a Prius here, a Lexus there -- and buckling on extraneous gear. Then in May, the tech titan took the wraps off a completely new prototype that it had built from scratch. (In December, it showed off the first fully functional prototype.) It looked rather like a cartoon car, but the real news was that there was no steering wheel, gas pedal or brake pedal -- no need for human controls when software and sensors are there to do the work.
Or not so fast. In August, California's Department of Motor Vehicles declared that Google's test vehicles will need those manual controls after all -- for safety's sake. The company agreed to comply with the state's rules, which went into effect in September, when it began testing the cars on private roads in October.
Regardless of who's making your future robo-car, the vehicle is going to have to be not just smart, but actually thoughtful. It's not enough for the car to know how far it is from nearby cars or what the road conditions are. The machine may well have to make no-win decisions, just as human drivers sometimes do in instantaneous, life-and-death emergencies. "The car is calculating a lot of consequences of its actions," Chris Gerdes, an associate professor of mechanical engineering, said at the Web Summit conference in Dublin, Ireland, in November. "Should it hit the person without a helmet? The larger car or the smaller car?"

Robots: Legging it out

So when do the robots finally become our overlords? Probably not in 2015, but there's sure to be more hand-wringing about both the machines and the artificial intelligence that could -- someday -- make them a match for homo sapiens. At the moment, the threat seems more mundane: when do we lose our jobs to a robot?
The inquisitive folks at Pew took that very topic to nearly 1,900 experts, including Vint Cerf, vice president at Google; Web guru Tim Bray; Justin Reich of Harvard University's Berkman Center for Internet & Society; and Jonathan Grudin, principal researcher at Microsoft. According to the resulting report, published in August, the group was almost evenly split -- 48 percent thought it likely that, by 2025, robots and digital agents will have displaced significant numbers of blue- and white-collar workers, perhaps even to the point of breakdowns in the social order, while 52 percent "have faith that human ingenuity will create new jobs, industries, and ways to make a living, just as it has been doing since the dawn of the Industrial Revolution."


Still, for all of the startling skills that robots have acquired so far, they're often not all there yet. Here's some of what we saw from the robot world in 2014:
Teamwork: Researchers at the École Polytechnique Fédérale De Lausanne in May showed off their "Roombots," cog-like robotic balls that can join forces to, say, help a table move across a room or change its height.
A sense of balance: We don't know if Boston Dynamics' humanoid Atlas is ready to trim bonsai trees, but it has learned this much from "The Karate Kid" (the original from the 1980s) -- it can stand on cinder blocks and hold its balance in a crane stance while moving its arms up and down.
Catlike jumps: MIT's cheetah-bot gets higher marks for locomotion. Fed a new algorithm, it can run across a lawn and bound like a cat. And quietly, too. "Our robot can be silent and as efficient as animals. The only things you hear are the feet hitting the ground," MIT's Sangbae Kim, a professor of mechanical engineering, told MIT News. "This is kind of a new paradigm where we're controlling force in a highly dynamic situation. Any legged robot should be able to do this in the future."
Sign language: Toshiba's humanoid Aiko Chihira communicated in Japanese sign language at the CEATEC show in October. Her rudimentary skills, limited for the moment to simple messages such as signed greetings, are expected to blossom by 2020 into areas such as speech synthesis and speech recognition.
Dance skills: Robotic pole dancers? Tobit Software brought a pair, controllable by an Android smartphone, to the Cebit trade show in Germany in March. More lifelike was the animatronic sculpture at a gallery in New York that same month -- but what was up with that witch mask?
Emotional ambition: Eventually, we'll all have humanoid companions -- at least, that's always been one school of thought on our robotic future. One early candidate for that honor could be Pepper, from Softbank and Aldebaran Robotics, which say the 4-foot-tall Pepper is the first robot to read emotions. This emo-bot is expected to go on sale in Japan in February.

Ray guns: Ship shape

Damn the photon torpedoes, and full speed ahead. That could be the motto for the US Navy, which in 2014 deployed a prototype laser weapon -- just one -- aboard a vessel in the Persian Gulf. Through some three months of testing, the device "locked on and destroyed the targets we designated with near-instantaneous lethality," Rear Adm. Matthew L. Klunder, chief of naval research, said in a statement. Those targets were rather modest -- small objects mounted aboard a speeding small boat, a diminutive Scan Eagle unmanned aerial vehicle, and so on -- but the point was made: the laser weapon, operated by a controller like those used for video games, held up well, even in adverse conditions.

Artificial intelligence: Danger, Will Robinson?

What happens when robots and other smart machines can not only do, but also think? Will they appreciate us for all our quirky human high and low points, and learn to live with us? Or do they take a hard look at a species that's run its course and either turn us into natural resources, "Matrix"-style, or rain down destruction?
laser-weapon-system-on-uss-ponce.jpg
When the machines take over, will they be packing laser weapons like this one the US Navy just tried out? John F. Williams/US Navy
As we look ahead to the reboot of the "Terminator" film franchise in 2015, we can't help but recall some of the dire thoughts about artificial intelligence from two people high in the tech pantheon, the very busy Musk and the theoretically inclined Stephen Hawking.
Musk himself more than once in 2014 invoked the likes of the "Terminator" movies and the "scary outcomes" that make them such thrilling popcorn fare. Except that he sees a potentially scary reality evolving. In an interview with CNBC in June, he spoke of his investment in AI-minded companies like Vicarious and Deep Mind, saying: "I like to just keep an eye on what's going on with artificial intelligence. I think there is potentially a dangerous outcome."
He has put his anxieties into some particularly colorful phrases. In August, for instance, Musk tweeted that AI is "potentially more dangerous than nukes." And in October, he said this at a symposium at MIT: "With artificial intelligence, we are summoning the demon. ... You know all those stories where there's the guy with the pentagram and the holy water and he's like... yeah, he's sure he can control the demon, [but] it doesn't work out."
Musk has a kindred spirit in Stephen Hawking. The physicist allowed in May that AI could be the "biggest event in human history," and not necessarily in a good way. A month later, he was telling John Oliver, on HBO's "Last Week Tonight," that "artificial intelligence could be a real danger in the not too distant future." How so? "It could design improvements to itself and outsmart us all."
But Google's Eric Schmidt, is having none of that pessimism. At a summit on innovation in December, the executive chairman of the far-thinking tech titan -- which in October teamed up with Oxford University to speed up research on artificial intelligence -- said that while our worries may be natural, "they're also misguided."

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Is AI a threat to humanity?

Excerpt from cnn.comImagine you're the kind of person who worries about a future when robots become smart enough to threaten the very existence of the human race. For years, you've been dismissed as a crackpot, consigned to the same category of peop...

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Climate Change is Preventing A New Ice Age, says White House Science Advisor





Excerpt from inquisitr.com

Climate change, particularly global warming, might be a good thing, according to President Obama’s science czar Dr. John Holdren.

In a recent online question and answer session from the White House, Holdren suggested that man-made global warming is preventing a new ice age. Holdren’s official government title is Assistant to the President for Science and Technology, and he holds degrees from MIT and Stanford. He has taught at Harvard and the University of California, Berkeley.

While the climate of the earth has changed over the millennia as a result of natural factors — principally changes in the tilt and orientation of the earth’s axis and rotation, and in the shape of its orbit around the sun — those changes occur far too gradually to have noticeable effects over a period of mere decades. In their current phases, moreover, they would be gradually cooling the earth — taking us to another ice age..."

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The End of the Space Race?




Excerpt from
psmag.com

A far cry from the fierce Cold War Space Race between the U.S. and the Soviet Union, exploration in the 21st century is likely to be a much more globally collaborative project.

Today, NASA’s goal to put astronauts on Mars by the 2030s could be a similarly unifying project. And not only in the United States. A far cry from the fierce Cold War Space Race between the U.S. and the Soviet Union, exploration in the 21st century is likely to be a far more globally collaborative project.

Why has the idea of reaching Mars captured the world? A trip to Mars is a priority for many scientific reasons—some believe it’s the planet that most resembles our own, and one that could answer the age-old question of whether we’re alone in the universe—but there’s also been a long popular fascination with the planet, Stofan observed. Ever since Giovanni Virginio Schiaparelli first observed the canali on Mars in the 1800s or when H.G. Wells wrote about aliens from Mars in his 1898 science fiction novel, The War of the Worlds, the planet has loomed large in the public’s imagination.

NASA’s view is to turn over to the private sector those projects that in a sense have become routine so that it can focus its resources on getting to Mars.

This spirit of trans-border ownership and investment seems set to continue. One key part of this is the Global Exploration Roadmap, an effort between space agencies like NASA, France’s Centre National d’Etudes Spatiales, the Canadian Space Agency, and the Japan Aerospace Exploration Agency, among many others, that is intended to aid joint projects from the International Space Station to expeditions to the Moon and near-Earth asteroids—and to reach Mars. On a recent trip to India’s space agency, Stofan recounted to me, she met with many Indian engineers who were just as excited as the Americans to get scientists up there, not only to explore, but also to begin nailing down the question of whether there was ever life on the red planet.

It’s also clear that the next stage of space exploration will not only be more global, but will equally involve greater private and public partnerships.

This environment feels a lot different from the secretive and adversarial Space Race days, when the U.S. and Soviet Union battled to reach the moon first. What’s changed? The Cold War is over, of course, but with it, the funding commitment may also be missing this time around. Stofan mentioned, in response to an audience question, that at the time of the Apollo missions, NASA got up to about four percent of the federal budget, while now it’s only around 0.4 percent. The dollars are still large, but perhaps increased international and private cooperation can be seen as an efficient, clever way to do more with less.

So, what does the future hold? NASA is extremely focused on how to get to Mars and back again safely, Stofan told the audience, but the fun role of science fiction, she suggested, is to start envisioning what the steps after that might be. For example, what might it be like to live on Mars? After all, science often gets its inspiration from the creative world. Just look at how similar mobile phones are to the communicators from Star Trek, she pointed out, or the fact that MIT students made a real-life version of the robotic sphere that Luke Skywalker trains with in Star Wars. “Stories are a great counterpoint to science,” she said.

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