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CRISPR-Cas9 modifies your DNA, under legal fire ~ Video

May 16, 2015 / / 0 Comments




Excerpt from slashgear.com

A revolutionary method of editing the human genome has this week become the subject of a patent war. Back in April of 2014, patents were awarded by the USPTO (United States Patent and Trademark Office) to the Broad Institutes’ Dr. Feng Zhang, MIT, and Harvard to develop the technology behind "CRISPR-Cas9". 
This April, the UC Board of Regents’ legal team spoke with the USPTO about reconsidering their action, suggesting they award the patent to the inventor of the original method, UC Berkeley’s Jennifer Doudna. One way or another, this radical DNA modifier must be made. 

We need X-Men, after all.


The following video will explain what this genome-editing piece of technological breakthrough is all about. CRISPR-Cas9 is what it's called, and getting in to your body to make changes on a DNA level is what it's going for.

CRISPR-Cas9 works as a tiny scissors.

Utilizing the natural bacterial-level protective system used by your body to fight infections, CRISPR-Cas9 replicates the sequences of target DNA strands and latches on.

It's the connector that CRISPR-Cas9 makes real, and really programmable.

Your body provides the Cas9.* The Cas9 is the nuclease enzyme that cuts DNA strands.

*Correction - BACTERIA have Cas9, not our human selves. As helpful commenter "John" put so eloquently, "So far it has only been found in bacterial cells, and that's one of the things that makes it so amazing--a relatively simple molecular system that replicates many of the functions of our elaborate adaptive immune response, all in a single prokaryotic cell!"

Screen Shot 2015-05-15 at 10.11.42 AM
ABOVE: Image comes via Nature; Addgene, By Jonathan Corum, via NYT.

When a DNA sequence is cut, it may attempt to re-form. In doing so, it can create mutations.

But that's a discussion for another day.

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Genetically altered twin monkeys have been made using the CRISPR-Cas9 method. As you'll see in DOI: http://dx.doi.org/10.1016/j.cell.2014.01.027 in Cell Symposia "Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos", these monkeys are living large on gene-altered action.

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Today what's important is that two groups are fighting for the patents involved in CRISPR-Cas9.

A paper published online June 28 2012 by Science authored by Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A. Doudna, and Emmanuelle Charpentier describes the method: "A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity."

You can find this paper under code DOI: 10.1126/science.1225829.

Dr. Zhang suggests he demonstrated the CRISPR genome editing method before the 2012 paper was published by Dr. Doudna and Dr. Charpentier and crew. Dr. Doudna and Dr. Charpentier and crew suggest say Dr. Zhang's notebook (used as proof for patents) does not prove genome editing before the 2012 paper was published.

Can't we all just get along? Think of the monkeys!

Click to zoom

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Archaeologists Believe they have Found the Ruins of a Legendary Monastery

May 13, 2015 / / 0 Comments



Excerpt from icelandreview.com

It is believed the remains of the much-searched-for Þykkvabær cloister may have been found. Icelandic and British archaeologists saw the remains of a very large building yesterday, using ultrasound techniques, at Álftaver in South Iceland.

The discovery came as a complete surprise, as it was not thought the remains of the cloister were in that area.

“I think we’ve just hit the jackpot, because I think we’ve discovered the remains of Þykkvabæjarklaustur. It came as a complete surprise, you can say that much. The remains are not on the site it was assumed the cloisters stood,” archaeology professor Steinunn Kristjánsdóttir told Stöð 2 television.

Þykkvabæjarklaustur, east of Mýrdalur, was a monastery of Augustine monks and its location has been lost to archaeologists until now. This week, ten Icelandic and British archaeologists have been searching for the remains with high tech instruments. The remains of an unusually big building were discovered under the ground yesterday, measuring around 40 x 45 meters.

“It is very big compared to the buildings of the time – as it is from the Middle Ages – and the footprint is around 1,500 square meters,” Steinunn says.

The cloister was in use from 1168 until 1550. Until recently it was assumed that Þykkvabæjarklaustur must have stood near the present-day Þykkvabæjarkirkja church, but searches revealed nothing; and this leads Steinunn to strongly believe yesterday’s find to be the lost cloisters. It is still possible, however, the remains are of a cow shed—but in that case it would be the cloister’s own cow shed and still therefore relevant.

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5 Ways to Master the Art of Letting Go

May 11, 2015 / / 0 Comments

Excerpt from huffingtonpost.comWe've all had to let go of things at some point or another. Whether it be a pet, friend, boyfriend, or simply graduating high school. We are constantly ending chapters in order to start new chapters.Though age and expe...

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Hubble Finds Giant Halo Around the Andromeda Galaxy

May 11, 2015 / / 0 Comments





 Excerpt from hubblesite.org

Scientists using NASA's Hubble Space Telescope have discovered that the immense halo of gas enveloping the Andromeda galaxy, our nearest massive galactic neighbor, is about six times larger and 1,000 times more massive than previously measured. The dark, nearly invisible halo stretches about a million light-years from its host galaxy, halfway to our own Milky Way galaxy. This finding promises to tell astronomers more about the evolution and structure of majestic giant spirals, one of the most common types of galaxies in the universe.

"Halos are the gaseous atmospheres of galaxies. The properties of these gaseous halos control the rate at which stars form in galaxies according to models of galaxy formation," explained the lead investigator, Nicolas Lehner of the University of Notre Dame, Indiana. The gargantuan halo is estimated to contain half the mass of the stars in the Andromeda galaxy itself, in the form of a hot, diffuse gas. If it could be viewed with the naked eye, the halo would be 100 times the diameter of the full Moon in the sky. This is equivalent to the patch of sky covered by two basketballs held at arm's length.

The Andromeda galaxy, also known as M31, lies 2.5 million light-years away and looks like a faint spindle, about 6 times the diameter of the full Moon. It is considered a near-twin to the Milky Way galaxy.

Because the gas in Andromeda's halo is dark, the team looked at bright background objects through the gas and observed how the light changed. This is a bit like looking at a glowing light at the bottom of a pool at night. The ideal background "lights" for such a study are quasars, which are very distant bright cores of active galaxies powered by black holes. The team used 18 quasars residing far behind Andromeda to probe how material is distributed well beyond the visible disk of the galaxy. Their findings were published in the May 10, 2015, edition of The Astrophysical Journal.

Earlier research from Hubble's Cosmic Origins Spectrograph (COS)-Halos program studied 44 distant galaxies and found halos like Andromeda's, but never before has such a massive halo been seen in a neighboring galaxy. Because the previously studied galaxies were much farther away, they appeared much smaller on the sky. Only one quasar could be detected behind each faraway galaxy, providing only one light anchor point to map their halo size and structure. With its close proximity to Earth and its correspondingly large footprint on the sky, Andromeda provides a far more extensive sampling of a lot of background quasars.
"As the light from the quasars travels toward Hubble, the halo's gas will absorb some of that light and make the quasar appear a little darker in just a very small wavelength range," explains co-investigator J. Christopher Howk, also of Notre Dame. "By measuring the dip in brightness in that range, we can tell how much halo gas from M31 there is between us and that quasar."

The scientists used Hubble's unique capability to study the ultraviolet light from the quasars. Ultraviolet light is absorbed by Earth's atmosphere, which makes it difficult to observe with a ground-based telescope. The team drew from about 5 years' worth of observations stored in the Hubble data archive to conduct this research. Many previous Hubble campaigns have used quasars to study gas much farther away than — but in the general direction of — Andromeda, so a treasure trove of data already existed.

But where did the giant halo come from? Large-scale simulations of galaxies suggest that the halo formed at the same time as the rest of Andromeda. The team also determined that it is enriched in elements much heavier than hydrogen and helium, and the only way to get these heavy elements is from exploding stars called supernovae. The supernovae erupt in Andromeda's star-filled disk and violently blow these heavier elements far out into space. Over Andromeda's lifetime, nearly half of all the heavy elements made by its stars have been expelled far beyond the galaxy's 200,000-light-year-diameter stellar disk.

What does this mean for our own galaxy? Because we live inside the Milky Way, scientists cannot determine whether or not such an equally massive and extended halo exists around our galaxy. It's a case of not being able to see the forest for the trees. If the Milky Way does possess a similarly huge halo, the two galaxies' halos may be nearly touching already and quiescently merging long before the two massive galaxies collide. Hubble observations indicate that the Andromeda and Milky Way galaxies will merge to form a giant elliptical galaxy beginning about 4 billion years from now.

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Carl Sagan’s Solar Sail Goes On Test Flight On May 20: Why You Should Care

May 10, 2015 / / 0 Comments

Excerpt  from techtimes.comMany of the technologies that are in use today such as the airplane and the internet were once ideas that became reality and it appears that this still goes true with the innovations of the future. Take for instance ...

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The Class-Domination Theory of Power

May 9, 2015 / / 0 Comments

by G. William DomhoffNOTE: WhoRulesAmerica.net is largely based on my book,Who Rules America?, first published in 1967 and now in its7th edition. This on-line document is presented as a summary of some of the main ideas in that book.Who has predominant power in the United States? The short answer, from 1776 to the present, is: Those who have the money -- or more specifically, who own income-producing land and businesses -- have the power. George Washington was one of the biggest landowner [...]

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Astronomers Giddy Over What They Call A Cosmic ‘Dinosaur Egg’ About To Hatch

May 9, 2015 / / 0 Comments



cosmic dinosaur egg
The Antennae galaxies, shown in visible light in a Hubble image (upper image), were studied with ALMA, revealing extensive clouds of molecular gas (center right image). One cloud (bottom image) is incredibly dense and massive, yet apparently star free, suggesting it is the first example of a prenatal globular cluster ever identified.


Excerpt from huffingtonpost.com

A dense cloud of gas 50 million light-years away has astronomers buzzing, and they're using all sorts of strange metaphors to get the rest of us to pay attention.

They've discovered what they think may be a globular cluster -- a big ball of up to one million stars -- on the verge of being born.

“This remarkable object looks like it was plucked straight out of the very early universe," Dr. Kelsey Johnson, an astronomer at the University of Virginia in Charlottesville and lead author on a paper about the research, said in a written statement. "To discover something that has all the characteristics of a globular cluster, yet has not begun making stars, is like finding a dinosaur egg that’s about to hatch.”

cosmic egg
ALMA image of dense cores of molecular gas in the Antennae galaxies. The round yellow object near the center may be the first prenatal example of a globular cluster ever identified. It is surrounded by a giant molecular cloud.


Johnson and her colleagues spotted the bizarre object, which they call the "Firecracker," using the Atacama Large Millimeter/submillimeter Array (ALMA) in the Atacama desert in Chile. It's located inside a pair of interacting galaxies known to scientists as NGC 4038/NGC 4039, or The Antennae Galaxies.

The Firecracker has a mass that's 50 times that of our sun, and is under an enormous amount of pressure -- roughly 10,000 times greater than the average pressure in interstellar space. According to the researchers, this makes it a good candidate for collapsing into a globular cluster within the next million years.

What do other scientists make of the discovery? Dr. Alison Peck, ALMA scientist at the National Radio Astronomy Observatory, who was not involved in the new research, called it "important" and said she was "really excited to hear about these results."
She told The Huffington Post in an email:
"One of the things that we all yearn to understand is how our surroundings formed, how our galaxy and our solar system came to be. To do this, since we can’t actually watch things change over time, (it just takes too long), we need to find similar objects at different stages of development and compare them. What Dr. Johnson’s team have found here is an analog of an object that we look for in the very early universe, but they’ve found it so close by that we’ll be able to make extremely detailed observations and find out much more about the physical conditions in this exciting region."
The research is set to be published in the Astrophysical Journal. 

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Mercury’s Mysterious Magnetic Past Goes Back 4 Billion Years

May 9, 2015 / / 0 Comments

 Excerpt from sci-tech-today.com Examining rocks on Mercury's surface, scientists using data from NASA's Messenger spacecraft have revealed that the planet probably had a much stronger magnetic field nearly 4 billion years ago.  The fi...

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Ascension Earth 2015-05-09 17:40:00

May 9, 2015 / / 0 Comments




 MAY 9, 2015: USGS map shows the location of the 4.5 quake (large blue dot in Ka'u) among the many smaller quakes that occurred on the Big Island over the last two weeks.

MAY 9, 2015: USGS map shows the location of the 4.5 quake (large blue dot in Ka'u) among the many smaller quakes that occurred on the Big Island over the last two weeks. - See more at: http://www.bigislandvideonews.com/2015/05/09/4-5-earthquake-shakes-big-island/#sthash.SS9H2Oiy.dpuf

 bigislandvideonews.com


Magnitude-4.5 earthquake shakes Big Island of Hawaii; people around isle report light shakingNAʻALEHU – A magnitude-4.5 earthquake located in the Kaʻū District shook the Island of Hawaii on Saturday, May 9, at 2:18 a.m., HST.  The quake was centered 5 miles north of Naʻalehu at a depth of 6 miles, according to Wes Thelen, the Seismic Network Manager for the USGS Hawaiian Volcano Observatory. There were three aftershocks (magnitudes 1.6, 1.5, 1.4) of the earthquake were recorded as of 3:30 a.m., HST. Scientists say additional aftershocks are possible and could be felt.  Over 70 reports claimed to feel the earthquake within an hour of the event. Light shaking has been reported across the island. At these shaking intensities (Intensity IV), damage to buildings or structures is not expected, scientists said.      Over the past 30 years, the area north of Nāʻālehu has experienced 6 earthquakes, including today’s event, with magnitudes greater than 4.0 and at depths of 5–13 km (3.1–8.1 mi). This area of Kaʻū is a seismically active region where a magnitude-6.2 earthquake occurred in 1919. Areas adjacent to this morning’s event experienced earthquakes of magnitudes 6.0, 7.1, and 7.9 in 1868.      The depth, location, and recorded seismic waves of today’s earthquake suggest a source on the large fault plane between the old ocean floor and overlying volcanic crust, a common source for earthquakes in this area. USGS Hawaiian Volcano Observatory   The earthquake caused no detectable changes in Kīlauea Volcano’s ongoing eruptions, on Mauna Loa, or at other active volcanoes on the Island of Hawaiʻi, says USGS. A magnitude-3.1 earthquake that occurred in Kīlauea Caldera about one minute before the magnitude-4.5 earthquake was unrelated to the Naʻalehu event.  The Big Island has been experiencing elevated seismicity beneath Kīlauea’s summit and upper East and Southwest Rift Zones the past few weeks.
NAʻALEHU – A magnitude-4.5 earthquake located in the Kaʻū District shook the Island of Hawaii on Saturday, May 9, at 2:18 a.m., HST.
The quake was centered 5 miles north of Naʻalehu at a depth of 6 miles, according to Wes Thelen, the Seismic Network Manager for the USGS Hawaiian Volcano Observatory. There were three aftershocks (magnitudes 1.6, 1.5, 1.4) of the earthquake were recorded as of 3:30 a.m., HST. Scientists say additional aftershocks are possible and could be felt.
Over 70 reports claimed to feel the earthquake within an hour of the event. Light shaking has been reported across the island. At these shaking intensities (Intensity IV), damage to buildings or structures is not expected, scientists said.
Over the past 30 years, the area north of Nāʻālehu has experienced 6 earthquakes, including today’s event, with magnitudes greater than 4.0 and at depths of 5–13 km (3.1–8.1 mi). This area of Kaʻū is a seismically active region where a magnitude-6.2 earthquake occurred in 1919. Areas adjacent to this morning’s event experienced earthquakes of magnitudes 6.0, 7.1, and 7.9 in 1868.
The depth, location, and recorded seismic waves of today’s earthquake suggest a source on the large fault plane between the old ocean floor and overlying volcanic crust, a common source for earthquakes in this area. USGS Hawaiian Volcano Observatory
The earthquake caused no detectable changes in Kīlauea Volcano’s ongoing eruptions, on Mauna Loa, or at other active volcanoes on the Island of Hawaiʻi, says USGS. A magnitude-3.1 earthquake that occurred in Kīlauea Caldera about one minute before the magnitude-4.5 earthquake was unrelated to the Naʻalehu event.
The Big Island has been experiencing elevated seismicity beneath Kīlauea’s summit and upper East and Southwest Rift Zones the past few weeks.
- See more at: http://www.bigislandvideonews.com/2015/05/09/4-5-earthquake-shakes-big-island/#sthash.SS9H2Oiy.dpuf

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The sun unleashes its biggest flare of the year

May 7, 2015 / / 0 Comments




Excerpt from dailytimes.com.pk

The sun has unleashed its most powerful flare of the year causing radio blackouts throughout the Pacific region.

The enormous X-class solar flare peaked at 6:11pm ET yesterday from a sunspot called Active Region 2339 (AR2339).

Solar flares are powerful bursts of radiation that, when intense enough, can disturb the atmosphere in the layer where GPS and communications signals travel - and scientists say they could get more powerful in the future.

This latest flare is classified as an X2.7. X-class denotes the most intense flares, while the number provides more information about its strength.

Despite the recent radio blackouts, scientists say the flare is unlikely to cause any further major issues here on Earth.

‘Given the impulsive nature of this event, as well as the source location on the eastern limb of the sun, we are not expecting a radiation storm at Earth,’ scientists with the U.S. Space Weather Prediction Center (SWPC) in Boulder, Colorado.

‘We will be on the lookout for new imagery from the Nasa Soho [Solar and Heliospheric Observatory] mission to determine if there was an associated coronal mass ejection (CME) with this event,’ they added.

‘Given the same logic above, however, we do not expect there to be one that would impact Earth.’

Yesterday Kazunari Shibata, an astrophysicist from Kyoto University in Japan, said the sun has the potential to unleash a flare of such a magnitude that it would be larger than anything humans have ever seen.

At the Space Weather Workshop in Colorado, Shibata said ‘superflares,’ that contain energy 1,000 times larger than what we have seen could be on their way.

He said there is evidence of this happening every 800 to 5,000 years on Earth,

Scientists say such a solar ‘super-storm’ would pose a ‘catastrophic’ and ‘long-lasting’ threat to life on Earth.

A superflare would induce huge surges of electrical currents in the ground and in overhead transmission lines, causing widespread power outages and severely damaging critical electrical components.

The largest ever solar super-storm on record occurred in 1859 and is known as the Carrington Event, named after the English astronomer Richard Carrington who spotted the preceding solar flare.

This massive CME released about 1022 kJ of energy - the equivalent to 10 billion Hiroshima bombs exploding at the same time - and hurled around a trillion kilos of charged particles towards the Earth at speeds of up to 3000 km/s.

However, its impact on the human population was relatively benign as our electronic infrastructure at the time amounted to no more than about 124,000 miles (200,000 km) of telegraph lines.

Nasa has also released incredible footage showing the sun unleashing a huge lick of plasma that increased the star’s visible hemisphere by almost half.

The solar filament, which exploded on April 28 and 29, was suspended above the sun due to strong magnetic fields that pushed outwards.

Solar astronomers around the world had their eyes on this unusually large filament and kept track as it erupted.

Nasa’s animation involves images taken from the orbiting Solar and Heliospheric Observatory using its Large Angle Spectrometric Coronagraph.

The diameter of the animation is about 30 million miles (45 million km) at the distance of the sun, or half of the diameter of the orbit of Mercury.

The white circle in the centre of the round disk represents the size of the sun, which is being blocked by the telescope in order to see the fainter material around it.

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A super-hot super-Earth spotted 40 light-years away

May 5, 2015 / / 0 Comments

An artist's depiction of the exoplanet 55 Cancri E with its molten surface exposed on the left, and covered in gas and ash on the right. (NASA/JPL - Caltech/R.Hurt)Excerpt from latimes.comScientists have found an extreme planet where the atmospheric ...

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Water may have been abundant a short billion years after Big Bang

May 4, 2015 / / 0 Comments





Excerpt from thespacereporter.com

The formation of water vapor after the Big Bang was constrained by the lack of oxygen; it and other elements heavier than hydrogen and helium were created only later on, in the death throes of the first generation of massive stars. Oxygen created by the demises of early stars was swept out in to space by the explosions of supernovae and stellar winds, eventually joining with hydrogen to form water.

This process created islands of gas replete with heavy elements, such as oxygen; these regions were more bereft of oxygen than gaseous regions in the modern Milky Way galaxy. However, a new study by Tel Aviv University and the Harvard-Smithsonian Center for Astrophysics (CfA) has determined that, in certain islands, water vapor might have been as plentiful as it is today, only a billion years after the Big Bang.

According to a CfA statement, the researchers looked at whether water could form in the primordial molecular clouds, which were deficient in oxygen. Their analysis indicated that large quantities of water could form at around 80 degrees Fahrenheit. Water molecules would have been shattered by ultraviolet light emitted by stars; however, after hundreds of millions of years, an equilibrium between water creation and destruction would be reached.

“We looked at the chemistry within young molecular clouds containing a thousand times less oxygen than our Sun. To our surprise, we found we can get as much water vapor as we see in our own galaxy,” said astrophysicist Avi Loeb of CfA.

The new study has been accepted for publication in the Astrophysical Journal and is accessible online.


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Quantum Entanglement Verified: Why Space Is Just The Construct That Gives The Illusion Of Separate Objects

May 3, 2015 / / 0 Comments

“Space is just the construct that gives the illusion that there are separate objects” – Dr. Quantum (see video below)There is a phenomenon so strange, so fascinating, and so counter to what we believe to be the known scientific laws of the universe, that Einstein himself could not wrap his head around it. It’s called “quantum entanglement,” though Einstein referred to it as “spooky action at a distance.”An [...]

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