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With the right expertise in molecular biology, one could start a basic laboratory to modify human embryos using a genome-editing computer technique all for a couple thousand dollars, according to a new report.
Genetic modification has received heightened scrutiny recently following last week’s announcement that Chinese researchers had, for the first time, successfully edited human embryos’ genomes. The team at Sun Yat-Sen University in Guangzhou, China, used CRISPR (clustered regularly interspaced palindromic repeats), a technique that relies on “cellular machinery” used by bacteria in defense against viruses.
This machinery is copied and altered to create specific gene-editing complexes, which include the wonder enzyme Cas9. The enzyme works its way into the DNA and can be used to alter the molecule from the inside. The combination is attached to an RNA guide that takes the gene-editing complex to its target, telling Cas9 where to operate.
Use of the CRISPR technique is not necessarily relegated to the likes of cash-flush university research operations, according to a report by Business Insider.
Geneticist George Church, who runs a top CRISPR research program at the Harvard Medical School, said the technique could be employed with expert knowledge and about half of the money needed to pay for an average annual federal healthcare plan in 2014 -- not to mention access to human embryos.
"You could conceivably set up a CRISPR lab for $2,000,” he said, according to Business Insider.
Other top researchers have echoed this sentiment.
"Any scientist with molecular biology skills and knowledge of how to work with [embryos] is going to be able to do this,” Jennifer Doudna, a biologist at the University of California, Berkeley, recently told MIT Tech Review, which reported that Doudna co-discovered how to edit genetic code using CRISPR in 2012.
Last week, the Sun Yat-Sen University research team said it attempted to cure a gene defect that causes beta-thalassemia (a genetic blood disorder that could lead to severe anemia, poor growth, skeletal abnormalities and even death) by editing the germ line. For that purpose they used a gene-editing technique based on injecting non-viable embryos with a complex, which consists of a protective DNA element obtained from bacteria and a specific protein.
"I suspect this week will go down as a pivotal moment in the history of medicine," wrote science journalist Carl Zimmer for National Geographic.
Response to the new research has been mixed. Some experts say the gene editing could help defeat genetic diseases even before birth. Others expressed concern.
“At present, the potential safety and efficacy issues arising from the use of this technology must be thoroughly investigated and understood before any attempts at human engineering are sanctioned, if ever, for clinical testing,” a group of scientists, including some who had worked to develop CRISPR, warned in Science magazine.
Meanwhile, the director of the US National Institutes for Health (NIH) said the agency would not fund such editing of human embryo genes.
“Research using genomic editing technologies can and are being funded by NIH,” Francis Collins said Wednesday. “However, NIH will not fund any use of gene-editing technologies in human embryos. The concept of altering the human germline in embryos for clinical purposes ... has been viewed almost universally as a line that should not be crossed.”
Although the discovery of CRISPR sequences dates back to 1987 – when it was first used to cure bacteria of viruses – its successes in higher animals and humans were only achieved in 2012-13, when scientists achieved a revolution by combining the resulting treatment system with Cas9 for the first time.
On April 17, the MIT’s Broad Institute announced that has been awarded the first-ever patent for working with the Crisp-Cas9 system.
The institute’s director, Eric Lander, sees the combination as “an extraordinary, powerful tool. The ability to edit a genome makes it possible to discover the biological mechanisms underlying human biology.”
The system’s advantage over other methods is in that it can also target several genes at the same time, working its way through tens of thousands of so-called 'guide' RNA sequences that lead them to the weapon to its DNA targets.
Meanwhile, last month in the UK, a healthy baby was born from an embryo screened for genetic diseases, using karyomapping, a breakthrough testing method that allows doctors to identify about 60 debilitating hereditary disorders.
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Artist's illustration of the U.S. Air Force's X-37B space plane in orbit. The mysterious spacecraft is scheduled to launch on its fourth mission on May 20, 2015. Credit: NASA Marshall Space Flight Center
The United States Air Force's X-37B space plane will launch on its fourth mystery mission next month. The unmanned X-37B space plane, which looks like a miniature version of NASA's now-retired space shuttle orbiter, is scheduled to blast off atop a United Launch Alliance Atlas V rocket from Florida's Cape Canaveral Air Force Station on May 20.
"We are excited about our fourth X-37B mission," Randy Walden, director of the Air Force Rapid Capabilities Office, said in a statement. "With the demonstrated success of the first three missions, we’re able to shift our focus from initial checkouts of the vehicle to testing of experimental payloads."
The X-37B's payloads and specific activities are classified, so it's unclear exactly what the spacecraft does while zipping around the Earth. But Air Force officials have revealed a few clues about the upcoming mission.
"The Air Force Research Laboratory (AFRL), Space and Missile Systems Center (SMC) and the Air Force Rapid Capabilities Office (AFRCO) are investigating an experimental propulsion system on the X-37B on Mission 4," Capt. Chris Hoyler, an Air Force spokesman, told Space.com via email.
"AFRCO will also host a number of advance materials onboard the X-37B for the National Aeronautics and Space Administration (NASA) to study the durability of various materials in the space environment," Hoyler added.
The Air Force owns two X-37B space planes, both of which were built by Boeing's Phantom Works division. The solar-powered spacecraft are about 29 feet long by 9.5 feet tall (8.8 by 2.9 meters), with a wingspan of 15 feet (4.6 m) and a payload bay the size of a pickup-truck bed. The X-37B launches vertically atop a rocket and lands horizontally on a runway, like the space shuttle did.
One of the two X-37B vehicles flew the program's first and third missions, which were known as OTV-1 and OTV-3, respectively. ("OTV" is short for "Orbital Test Vehicle.") The other spacecraft flew OTV-2. Air Force officials have not revealed which space plane will be going to orbit on the upcoming mission.
OTV-1 launched in April 2010 and landed in December of that year, staying in orbit for 225 days. OTV-2 blasted off in March 2011 and circled Earth for 469 days, coming down in June 2012. OTV-3 launched in December 2012 and stayed aloft for a record-breaking 675 days, finally landing in October 2014.
A recovery team processes the U.S. Air Force's X-37B space plane after the robotic spacecraft's successful landing at Vandenberg Air Force Base in California on Oct. 17, 2014. The touchdown marked the end of the X-37B’s third space mission. Credit: Boeing
If Air Force officials know how long OTV-4 is going to last, they're not saying.
"The X-37B is designed for an on-orbit duration of 270 days," Hoyler said. "Longer missions have been demonstrated. As with previous missions, the actual duration will depend on test objectives, on-orbit vehicle performance and conditions at the landing facility."
The secrecy surrounding the X-37B and its payloads has fueled speculation in some quarters that the vehicle could be a space weapon of some sort. But Air Force officials have repeatedly refuted that notion.
"The primary objectives of the X-37B are twofold: reusable spacecraft technologies for America's future in space, and operating experiments which can be returned to, and examined, on Earth," Air Force officials wrote in on online X-37B fact sheet.
"Technologies being tested in the program include advanced guidance, navigation and control; thermal protection systems; avionics; high-temperature structures and seals; conformal reusable insulation, lightweight electromechanical flight systems; and autonomous orbital flight, re-entry and landing."
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A Type Ia supernova, SN1994D, is shown exploding in lower left corner of the image at the top of the page of the galaxy NGC 4526 taken by the Hubble Space Telescope. (High-Z Supernova Search Team, HST, NASA)Excerpt from dailygalaxy.com Cer...
Since 1975, when Hawking showed that black holes evaporate from our universe, physicists have tried to explain what happens to a black hole’s information.
What happens to the information that goes into a black hole? Is it irretrievably lost? Does it gradually or suddenly leak out? Is it stored somehow? Physicists have puzzled for decades over what they call the information loss paradox in black holes. A new study by physicists at University at Buffalo – published in March, 2015 in the journal in Physical Review Letters – shows that information going into a black hole is not lost at all.
Instead, these researchers say, it’s possible for an observer standing outside of a black hole to recover information about what lies within.
Dejan Stojkovic, associate professor of physics at the University at Buffalo, did the research with his student Anshul Saini as co-author. Stojkovic said in a statement:
According to our work, information isn’t lost once it enters a black hole. It doesn’t just disappear.
What sort of information are we talking about? In principle, any information drawn into a black hole has an unknown future, according to modern physics. That information could include, for example, the characteristics of the object that formed the black hole to begin with, and characteristics of all matter and energy drawn inside.
Stojkovic says his research “marks a significant step” toward solving the information loss paradox, a problem that has plagued physics for almost 40 years, since Stephen Hawking first proposed that black holes could radiate energy and evaporate over time, disappearing from the universe and taking their information with them.
Disappearing information is a problem for physicists because it’s a violation of quantum mechanics, which states that information must be conserved.
According to modern physics, any information related to an astronaut entering a black hole – for example, height, weight, hair color – may be lost. This notion is known as the ‘information loss paradox’ of black holes because it violates quantum mechanics. Artist’s concept via Nature.
Stojkovic says that physicists – even those who believed information was not lost in black holes – have struggled to show mathematically how the information is preserved. He says his new paper presents explicit calculations demonstrating how it can be preserved. His statement from University at Buffalo explained:
In the 1970s, [Stephen] Hawking proposed that black holes were capable of radiating particles, and that the energy lost through this process would cause the black holes to shrink and eventually disappear. Hawking further concluded that the particles emitted by a black hole would provide no clues about what lay inside, meaning that any information held within a black hole would be completely lost once the entity evaporated.
Though Hawking later said he was wrong and that information could escape from black holes, the subject of whether and how it’s possible to recover information from a black hole has remained a topic of debate.
Stojkovic and Saini’s new paper helps to clarify the story. Instead of looking only at the particles a black hole emits, the study also takes into account the subtle interactions between the particles. By doing so, the research finds that it is possible for an observer standing outside of a black hole to recover information about what lies within. Interactions between particles can range from gravitational attraction to the exchange of mediators like photons between particles. Such “correlations” have long been known to exist, but many scientists discounted them as unimportant in the past.
Stojkovic added:
These correlations were often ignored in related calculations since they were thought to be small and not capable of making a significant difference. Our explicit calculations show that though the correlations start off very small, they grow in time and become large enough to change the outcome.
Artist’s impression of a black hole, via Icarus
Bottom line: Since 1975, when Stephen Hawking and Jacob Bekenstein showed that black holes should slowly radiate away energy and ultimately disappear from the universe, physicists have tried to explain what happens to information inside a black hole. Dejan Stojkovic and Anshul Saini, both of University at Buffalo, just published a new study that contains specific calculations showing that information within a black hole is not lost.
Excerpt from eaglecurrent.com NASA is joining in an effort to have an understanding of the presence of a methane hotspot over the 4 corners area of the United States. How severe is the atmospheric feature?A methane hotspot hovering over t...
Excerpt from charismanews.comA new map of the U.S. could include a state called Jefferson, made up of Northern California and Southern Oregon, a new state called Western Maryland and a new state called North Colorado. (CBN)
If you mention the word secession most people think of the South during the Civil War. But today, a new movement is gaining steam because of frustration over a growing, out-of-control federal government.
A number of conservative, rural Americans are taking about seceding and creating their own states, meaning a new map of the United States of America could include the following:
A 51st state called Jefferson, made up of Northern California and Southern Oregon
A new state called Western Maryland
A new state called North Colorado
These are real movements gaining traction with voters across the country. Jeffrey Hare runs the 51st State Initiative in Colorado, an effort to fight an out-of-control legislature trying to ram big government policies down the throats of voters.
"We're at this point of irreconcilable differences," Hare told CBN News.
Secessionist talk has filled town hall meetings and the divide discussed is not just ideological.
"It's predominately left versus right, but it's urban versus rural because you typically find more typical conservative values in rural America," Hare said.
An Attack on Colorado?
That's the crux of the issue. Rural Americans across many states feel they're not being heard. Their laundry list is long and at the top of that list are stricter gun control laws.
According to Weld County, Colo., Sheriff John Cooke, the state legislature is out of control.
"They are out of touch with rural Colorado," he said. "There is an attack on rural Colorado and it's not just on gun control laws. It's on several of the other bills that they passed."
Government mandates on renewable energy, environmental policies restricting oil and gas drilling, and controversial social issues like gay marriage have also led to this divide and talk of secession.
Organizers want to create "North Colorado," an idea that went to voters in 11 counties this past fall. But not everyone in Colorado thinks secession is a great idea.
"I don't think that's necessarily the way to make something happen within the area you live," Colorado resident Greg Howe told CBN News. "You're supposed to work within our electoral services."
The so-called secession movement in Colorado had mixed results this past November. Some counties approved it. Others didn't.
But the organizers of the 51st State Initiative are undaunted, saying this type of movement takes time.
"Movements take a while; education takes time," Hare said. "People do have a hard time saying ,'I want to live in a different state,' even though physically they live in the same house."
"It's hard for them since their lives have been Coloradoans," he explained. "Their whole lives to say that 'I'm going to be a new Coloradoan' or 'I want to live in the state of liberty' or something different."
An 'Amicable' Divorce
That desire for something different can also be felt in Arizona, Michigan, and in Western Maryland where thousands have signed secession petitions.
One website reads, "We intend to exercise our right of self-determination and self-governance to better secure our rights to life, liberty, and the pursuit of happiness."
Scott Strzelczyk, the leader of the Western Maryland movement, is ready to get going.
"If they are not going to listen or take our needs into consideration and govern in a way that's more in accordance with the way we want to be governed we are seeking an amicable divorce," he said.
Meanwhile, in Northern California and Southern Oregon, activists want to come together in the state of "Jefferson."
Their proposed state flag includes two "Xs," representing their feeling of being double-crossed by the state capitals of Sacramento, Calif., and Salem, Ore.
No Small Task
Creating a new state isn't easy. The last time a state actually gave up territory was in 1820, when Maine split from Massachusetts. Since then, additional efforts have been unsuccessful.
The first step is getting it passed by the state legislature and then the U.S. Congress.
"This is a valid constitutional process that our founding fathers specifically wrote into the Constitution," Hare said. "Well, if they didn't write this into the Constitution to be used, then why did they write it in?"
But supporters have an uphill battle since the media will not be their friend.
"The danger is once the outside media start to grab hold of it, the attention is on the difficulty, the almost impossibility of it happening," professor Derek Everett, with Metropolitan State University in Denver, explained.
Voter 'Disconnect'
State secession proponents, like Roni Bell Sylvester of Colorado, say they will keep fighting because the dismissive attitude of state legislative bodies must end.
"I find the sort of arrogant, dismissive to be further proof as to just how disconnected the urban is from the rural," Sylvester said.
Movements like the one in Colorado and other states could be just the beginning—at least that's the talk at town hall meetings in places like Colorado and elsewhere.
It's called 'voter disconnect" where the people say they've had enough and are crying out for something to be done.
"We, at some point, have to figure out a way to get our point across or at least be able to have a dialogue and not be ignored because you haven't seen anything yet over the next 5 to 10 years," one resident warned at a recent town hall meeting in Colorado.
As for Hare, he said it boils down to one simple concept.
"I think ultimately what people want, whether you look at it from a right or left paradigm, is government to stay out of their business," he said.
Mike Barrett, Natural SocietyIf sales for antidepressants such as Zoloft, Lexapro, or Prozac tell us anything, it’s that depression is sweeping the nation. But a new study questions the validity of most of these sales. The study has found that the majority of individuals on antidepressants – a whopping 69% – do not even meet the criteria for clinical depression. These individuals are likely just experiencing normal sadness and hardships that most of u [...]
Excerpt from spacenews.com Recently, several space advocacy groups joined forces to form the Alliance for Space Development. Their published objectives include a mention of obvious near-term goals such as supporting the commercial crew program, transitioning from use of the International Space Station to future private space stations and finding ways to reduce the cost of access to space. What is notably missing from these objectives and those of many other space agencies, companies and advocacy groups is any mention of building a permanent settlement on the moon. It’s as if the lunar surface has become our crazy uncle that we all acknowledge exists but we’d prefer not to mention (or visit). What made the next logical step in mankind’s progression beyond the bounds of Earth such a taboo subject? If, as the Alliance for Space Development suggests, our nation wishes to move toward a path of permanent space settlements, the most logical step is our own planet’s satellite.
A 2006 NASA conception of a lunar base. Credit: NASA
A base on the lunar surface is a better place to study space settlement than a space station or Mars for many reasons. Unlike a space station, the base does not have to contend with aerodynamic drag, attitude control issues or contamination and impingement from its own thrusters. Unlike a space station, which exists in a total vacuum and resource void, a lunar base has access to at least some surface resources in the forms of minerals, albeit fewer than might be available on Mars. Many people naturally want to go directly to Mars as our next step. Even SpaceX has publicly stated this as its ultimate goal, with SpaceX President Gwynne Shotwell noting that “we’re not moon people.” However, Mars makes sense only if we think the technology is ready to safely support humans on another surface for long periods of time. Furthermore, budget restrictions make an ambitious goal like going immediately to Mars an unlikely prospect. Why are we afraid to take the seemingly necessary baby steps of developing the technology for a long-term base on a surface that can be reached in mere days instead of months? The tendency to want to skip a lunar settlement is not a new phenomenon. Even before the first landing on the moon, U.S. and NASA political leadership was contemplating the future of manned space, and few of the visions involved a lunar base. The early space program was driven by Cold War competition with Moscow, and the kinds of ideas that circulated at the time involved milestones that seemed novel such as reusable spaceplanes, nuclear-powered rockets, space stations and missions to Mars.
When the United States was on the verge of a series of landings on the moon, building a permanent base just didn’t seem like much of a new giant leap. NASA's ConstellationNASA’s Constellation program, featuring the Orion manned capsule set atop the Ares 1 launch vehicle, was meant to send astronauts back to the moon. Credit: NASA The idea of a lunar landing mission was not reintroduced seriously until the George W. Bush administration and the introduction of the Constellation program. This program came at a complex time for NASA: The space shuttle was recovering from the Columbia disaster, the space station was in the midst of construction and the United States found itself with large budget deficits. However, despite its budgetary and schedule problems, which are common in any serious aerospace development project from space programs to jumbo-jet development, it provided NASA with a vision and a goal that were reasonable and sensible as next steps toward a long-term future of exploration beyond Earth.
Constellation was nevertheless canceled, and we have since returned to a most uncommon sense. The decision to avoid any sort of lunar activity in current space policy may have been biased by the Obama administration’s desire to move as far away as possible from the policies of the previous administration.
Regardless of the cause, discussion of returning to the moon is no longer on the table. Without the moon, the only feasible mission that NASA could come up with that is within reach given the current technology and budget is the Asteroid Redirect Mission. Even planetary scientists have spoken out against the mission, finding that it will provide little scientific value. It will also provide limited engineering and technology value, if we assume that our long-term goal is to permanently settle space. The experience gained from this sort of flight has little applicability to planetary resource utilization, long-term life support or other technologies needed for settlement.
If we are to have a program of manned space exploration, we must decide what the long-term goals of such a program should be, and we should align our actions with those goals. When resources such as funding are limited, space agencies and political leaders should not squander these limited resources on missions that make no sense. Instead, the limited funding should be used to continue toward our long-term goals, accepting a slower pace or slight scale-back in mission scope. Establishing a permanent human settlement in space is a noble goal, one that will eventually redefine humanity. Like explorers before us, it is also not a goal that will be achieved in a short period of time. We would be wise to keep our eyes on that goal and the road needed to get us there. And the next likely stop on that road is a permanent home just above our heads, on the surface of the brightest light in the night sky.
Paul Brower is an aerospace systems engineer on the operations team for the O3b Networks satellite fleet. He previously worked in mission control at NASA for 10 years.
Recently, several space advocacy groups joined forces to form the Alliance for Space Development. Their published objectives include a mention of obvious near-term goals such as supporting the commercial crew program, transitioning from use of the International Space Station to future private space stations and finding ways to reduce the cost of access to space. What is notably missing from these objectives and those of many other space agencies, companies and advocacy groups is any mention of building a permanent settlement on the moon. It’s as if the lunar surface has become our crazy uncle that we all acknowledge exists but we’d prefer not to mention (or visit). What made the next logical step in mankind’s progression beyond the bounds of Earth such a taboo subject? If, as the Alliance for Space Development suggests, our nation wishes to move toward a path of permanent space settlements, the most logical step is our own planet’s satellite. A 2006 NASA conception of a lunar base. Credit: NASAA base on the lunar surface is a better place to study space settlement than a space station or Mars for many reasons. Unlike a space station, the base does not have to contend with aerodynamic drag, attitude control issues or contamination and impingement from its own thrusters. Unlike a space station, which exists in a total vacuum and resource void, a lunar base has access to at least some surface resources in the forms of minerals, albeit fewer than might be available on Mars. Many people naturally want to go directly to Mars as our next step. Even SpaceX has publicly stated this as its ultimate goal, with SpaceX President Gwynne Shotwell noting that “we’re not moon people.” However, Mars makes sense only if we think the technology is ready to safely support humans on another surface for long periods of time. Furthermore, budget restrictions make an ambitious goal like going immediately to Mars an unlikely prospect. Why are we afraid to take the seemingly necessary baby steps of developing the technology for a long-term base on a surface that can be reached in mere days instead of months? The tendency to want to skip a lunar settlement is not a new phenomenon. Even before the first landing on the moon, U.S. and NASA political leadership was contemplating the future of manned space, and few of the visions involved a lunar base. The early space program was driven by Cold War competition with Moscow, and the kinds of ideas that circulated at the time involved milestones that seemed novel such as reusable spaceplanes, nuclear-powered rockets, space stations and missions to Mars. When the United States was on the verge of a series of landings on the moon, building a permanent base just didn’t seem like much of a new giant leap. NASA’s Constellation program, featuring the Orion manned capsule set atop the Ares 1 launch vehicle, was meant to send astronauts back to the moon. Credit: NASAThe idea of a lunar landing mission was not reintroduced seriously until the George W. Bush administration and the introduction of the Constellation program. This program came at a complex time for NASA: The space shuttle was recovering from the Columbia disaster, the space station was in the midst of construction and the United States found itself with large budget deficits. However, despite its budgetary and schedule problems, which are common in any serious aerospace development project from space programs to jumbo-jet development, it provided NASA with a vision and a goal that were reasonable and sensible as next steps toward a long-term future of exploration beyond Earth. Constellation was nevertheless canceled, and we have since returned to a most uncommon sense. The decision to avoid any sort of lunar activity in current space policy may have been biased by the Obama administration’s desire to move as far away as possible from the policies of the previous administration. Regardless of the cause, discussion of returning to the moon is no longer on the table. Without the moon, the only feasible mission that NASA could come up with that is within reach given the current technology and budget is the Asteroid Redirect Mission. Even planetary scientists have spoken out against the mission, finding that it will provide little scientific value. It will also provide limited engineering and technology value, if we assume that our long-term goal is to permanently settle space. The experience gained from this sort of flight has little applicability to planetary resource utilization, long-term life support or other technologies needed for settlement.
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If we are to have a program of manned space exploration, we must decide what the long-term goals of such a program should be, and we should align our actions with those goals. When resources such as funding are limited, space agencies and political leaders should not squander these limited resources on missions that make no sense. Instead, the limited funding should be used to continue toward our long-term goals, accepting a slower pace or slight scale-back in mission scope. Establishing a permanent human settlement in space is a noble goal, one that will eventually redefine humanity. Like explorers before us, it is also not a goal that will be achieved in a short period of time. We would be wise to keep our eyes on that goal and the road needed to get us there. And the next likely stop on that road is a permanent home just above our heads, on the surface of the brightest light in the night sky.
Paul Brower is an aerospace systems engineer on the operations team for the O3b Networks satellite fleet. He previously worked in mission control at NASA for 10 years. - See more at: http://spacenews.com/op-ed-why-the-u-s-gave-up-on-the-moon/#sthash.czfTscvg.dpuf
MRSA attacks a human cell. The bacteria shown is the strain MRSA 252, a leading cause of hospital-associated infections. (Rocky Mountain Laboratories, NIAID, NIH)
Even in the age of AIDS, avian flu and Ebola, methicillin-resistant Staphylococcus aureus, better known as MRSA, is terrifying.
The superbug, which is resistant to conventional antibiotics because of their overuse, shrugs at even the deadliest weapons modern medicine offers. The Centers for Disease Control and Prevention estimated MRSA contributed to the deaths of more than 5,000 people in the United States in 2013. It even attacked the NFL, and some say it could eventually kill more people than cancer. And presidential commissions have advised that technological progress is the only way to fight MRSA. But researchers in the United Kingdom now report that the superbug proved vulnerable to an ancient remedy. The ingredients? Just a bit of garlic, some onion or leek, copper, wine and oxgall — a florid name for cow’s bile.
This medicine sounds yucky, but it’s definitely better than the bug it may be able to kill.
“We were absolutely blown away by just how effective the combination of ingredients was,” Freya Harrison of the University of Nottingham, who worked on the research, told the BBC.
The oxgall remedy, billed as an eye salve, was found in a manuscript written in Old English from the 10th century called “Bald’s Leechbook” — a sort of pre-Magna Carta physician’s desk reference. Garlic and copper are commonly thought to have antibiotic or antimicrobial properties, but seeing such ingredients in a home remedy at Whole Foods is a far cry from researchers killing a superbug with it. According to Christina Lee, an associate professor in Viking studies at Nottingham, the MRSA research was the product of conversations among academics of many stripes interested in infectious disease and how people fought it before antibiotics.
“We were talking about the specter of antibiotic resistance,” she told The Washington Post in a phone interview. The medical researchers involved in the discussions said to the medievalists: “In your period, you guys must have had something.”
Not every recipe in Bald’s Leechbook is a gem. Other advice, via a translation from the Eastern Algo-Saxonist: “Against a woman’s chatter; taste at night fasting a root of radish, that day the chatter cannot harm thee.” And: “In case a man be a lunatic; take skin of a mereswine or porpoise, work it into a whip, swinge the man therewith, soon he will be well. Amen.” Though the Leechbook may include misses, it may help doctors find a solution to a problem that only seems to be getting worse.
If the oxgall remedy proves effective against MRSA outside of the lab — which researchers caution it may not — it would be a godsend. Case studies of MRSA’s impact from the CDC’s charmingly named Morbidity and Mortality Weekly Report seem medieval.
“In July 1997, a 7-year-old black girl from urban Minnesota was admitted to a tertiary-care hospital with a temperature of 103 F.” Result: Death from pulmonary hemorrhage after five weeks of hospitalization.
“In January 1998, a 16-month-old American Indian girl from rural North Dakota was taken to a local hospital in shock and with a temperature of 105.2 F.” Result: After respiratory failure and cardiac arrest, death within two hours of hospital admission.
“In January 1999, a 13-year-old white girl from rural Minnesota was brought to a local hospital with fever, hemoptysis” — that’s coughing up blood — “and respiratory distress.” The result: Death from multiple organ failure after seven days in the hospital.
“We believe modern research into disease can benefit from past responses and knowledge, which is largely contained in non-scientific writings,” Lee told the Telegraph. “But the potential of these texts to contribute to addressing the challenges cannot be understood without the combined expertise of both the arts and science.”
Lee stressed that it was the combination of ingredients that proved effective against MRSA — which shows that people living in medieval times were not as barbaric as popularly thought. Even 1,000 years ago, when people got sick, other people tried to figure out how to help.
“We associate ‘medieval’ with dark, barbaric,” Lee said. “… It’s not. I’ve always believed in the pragmatic medieval ages.” The research will be presented at the Annual Conference of the Society for General Microbiology in Birmingham. In an abstract for the conference, the team cautioned oxgall was no cure-all. “Antibacterial activity of a substance in laboratory trials does not necessarily mean the historical remedy it was taken from actually worked in toto,” they wrote.
Lee said researchers hope to turn to other remedies in Bald’s Leechbook — including purported cures for headaches and ulcers — to see what other wisdom the ancients have to offer.
“At a time when you don’t have microscope, medicine would have included things we find rather odd,” she said. “In 200 years, people will judge us.”
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In the hunt for alien life, our first glimpse of extraterrestrials may be in the rainbow of colors seen coming from the surface of an exoplanet.
That's the deceptively simple idea behind a study led by Siddharth Hegde at the Max Planck Institute for Astronomy in Germany. Seen from light-years away, plants on Earth give our planet a distinctive hue in the near-infrared, a phenomenon called red edge. That's because the chlorophyll in plants absorbs most visible light waves but starts to become transparent to wavelengths on the redder end of the spectrum. An extraterrestrial looking at Earth through a telescope could match this reflected color with the presence of oxygen in our atmosphere and conclude there is life here.
Eight of the 137 microorganism samples used to measure biosignatures for the catalog of reflection signatures of Earth life forms. In each panel, the top is a regular photograph of the sample and the bottom is a micrograph, a version of the top image zoomed-in 400 times.
Plants, though, have only been around for 500 million years—a relative blip in our planet's 4.6-billion-year history. Microbes dominated the scene for some 2.5 billion years in the past, and some studies suggest they will rule the Earth again for much of its future. So Hegde and his team gathered 137 species of microorganisms that all have different pigments and that reflect light in specific ways. By building up a library of the microbes' reflectance spectra—the types of colors those microscopic critters reflect from a distance—scientists examining the light from habitable exoplanets can have a plethora of possible signals to search for, the team argues this week in the Proceedings of the National Academy of Sciences.
"No one had looked at the wide range of diverse life on Earth and asked how we could potentially spot such life on other planets, and include life from extreme environments on Earth that could be the 'norm' on other planets," Lisa Kaltenegger, a co-author on the study, says via email. "You can use it to model an Earth that is different and has different widespread biota and look how it would appear to our telescopes."
To make sure they got enough diversity, the researchers looked at temperate-dwelling microbes as well as creatures that live in extreme environments like deserts, mineral springs, hydrothermal vents or volcanically active areas.
While it might seem that alien life could take a huge variety of forms—for instance, something like the silicon-based Horta from Star Trek—it's possible to narrow things down if we restrict the search to life as we know it. First, any life-form that is carbon-based and uses water as a solvent isn't going to like the short wavelengths of light far in the ultraviolet, because this high-energy UV can damage organic molecules. At the other end of the spectrum, any molecule that alien plants (or their analogues) use to photosynthesize won't be picking up light that's too far into the infrared, because there's not enough energy at those longer wavelengths.
In addition, far-infrared light is hard to see through an Earth-like atmosphere because the gases block a lot of these waves, and whatever heat the planet emits will drown out any signal from surface life. That means the researchers restricted their library to the reflected colors we can see when looking at wavelengths in the visible part of the spectrum, the longest wavelength UV and short-wave infrared.
The library won't be much use if we can't see the planets' surfaces in the first place, and that's where the next generation of telescopes comes in, Kaltenegger says. The James Webb Space Telescope, scheduled for launch in 2018, should be able to see the spectra of relatively small exoplanet atmospheres and help scientists work out their chemical compositions, but it won't be able to see any reflected spectra from material at the surface. Luckily, there are other planned telescopes that should be able to do the job. The European Extremely Large Telescope, a 40-meter instrument in Chile, will be complete by 2022. And NASA's Wide Field Infrared Survey Telescope, which is funded and in its design stages, should be up and running by the mid-2020s.
Another issue is whether natural geologic or chemical processes could look like life and create a false signal. So far the pigments from life-forms look a lot different from those reflected by minerals, but the team hasn't examined all the possibilities either, says Kaltenegger. They hope to do more testing in the future as they build up the digital library, which is now online and free for anyone to explore at biosignatures.astro.cornell.edu.
Excerpt from huffingtonpost.comWhen the National Atomic Testing Museum of Las Vegas opened its "Area 51: Myth or Reality" exhibit two years ago, it became an instant hit. It wasn't just the only place that had a comprehensive knowledge of Area 51 -...
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thank U Mission Control with the way of gratitude for the co-creation and presentation of every piece of information needed in order to complete this mission to disarm dysfunctional patterns Thank you and I’m grateful that I was able to help provide this resource to me and myself and all those who may have you sit and understand it and made it one day find resonate within your field of Attraction so that we may need to maybe get a team there I decided to take another job occupation of your next transition or whatever you choose to focus on next but thank you so much to all the support world-wise that she my homeboys and homegirls over in the Netherlands and Gaia and dr. Diana loopy Philip from France, Alison Maclean, Tolosa Diane Abigail the gfol federation’s confederations and I’ll local Earth groups, dashiki Niro’s the Blu-rays anybody who has been a contributor on this site directly or indirectly providing you help spread through email a different means information that will help raise and lift anybody by not telling him what to do and I appreciate you that I’m not the only religion that may be planting seeds and invited them to investigate for themselves and come to their own understanding and then have the ability to take ownership of their own creation through their own understanding that’s the siren Divinity is about and that’s why we were created to be enough to human beings are it’s time we finish his transition and stop playing games with our probability feels acting like what maybe I’ll be able to work around it there isn’t all roads lead to Rome in the end so he was a program eyelash it’s not going to your face and this is the truth of your life except it start creating from it responsibility for every creation you make all the way down to the thought that’s truly what it’s about we’re about to make a tremendous leap and jump so to speak, was kind of like when the universe itself has created this imagine I can’t even put it into words cuz I don’t have words given no Credence but I invite you I’m honored to have this experience I have one things I cannot even comprehend could cheap or contemplated are received before and it will definitely have any impact in my next transition are eBay’s Road focus on my next project but anyways thank you grateful 14 years they playing and at times her moment of reflection in celebration anytime the turbulence and frequency shift and lots of communication because they’re over there and you’re over here and you’re just too far apart there’s too much interference in between you because of the separation that’s occurring in our own evolutionary stages so many ways to love you like Battlefield thank you president and of course feels cool tribe.net the new entry for fun and have to cancel our society and that’s all I can pull off the top of my head right now in New Zealand and Australia especially the code writers who wrote text eons ago to speak to us right now today and I first had conversation is Remembrance and everybody involved with integrating new variables and help me decide collectively let the new 0 0 1 0 1 1 0 reality in our new home everything will be like more sooner than from here to there were already here there’s nowhere to go nowhere to be no way that she the only thing we have to do is be there now. InJoY!
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