Excerpt from huffingtonpost.comBy Debbie FinkCo-authored by Karen Bloch MorseThere is nothing easy or natural about watching your 41-year-old friend (of 41 years) -- who, by all counts, looks healthy -- ...
Tag: healthy (page 3 of 7)
by G. William DomhoffNOTE: WhoRulesAmerica.net is largely based on my book,Who Rules America?, first published in 1967 and now in its7th edition. This on-line document is presented as a summary of some of the main ideas in that book.Who has predominant power in the United States? The short answer, from 1776 to the present, is: Those who have the money -- or more specifically, who own income-producing land and businesses -- have the power. George Washington was one of the biggest landowner [...]
Excerpt from cnet.comEnceladus may have a warm ocean beneath its icy surface, but it may also be shooting through that crust in big sheets, perhaps filled with sea monkeys. We already know that Saturn's ...
Heather Callaghan, ContributorWaking TimesNanotechnology – that is, metal oxide particles* such as titanium dioxide – are increasingly used in the commercial food supply, consumer goods, body care and in water treatment.The gut microbiome is today’s most appealing topic of science because it was previously unacknowledged by the medical community just how important gut health is to the human brain, hormones, immunity, mental health and more. Maintaining a h [...]
From today.com After a long week, there's nothing better than a healthy dose of cuteness. Inspired by the sweet moment when TODAY anchor Savannah Guthrie's baby,...
Marco Torres, Prevent DiseaseWith a progressively educated population becoming more aware of the inherent dangers of the conventional food supply, urban farming has become hugely popular. However, more people are also becoming aware of contaminated soil and how heavy metals pose potential risks to their food crops. As backyard gardening continues to explode in popularity, we must ask how contaminated is our soil?Many municipalities in many countries are embracing urban agri [...]
Reuters
With the right expertise in molecular biology, one could start a basic laboratory to modify human embryos using a genome-editing computer technique all for a couple thousand dollars, according to a new report.
Genetic modification has received heightened scrutiny recently following last week’s announcement that Chinese researchers had, for the first time, successfully edited human embryos’ genomes.
The team at Sun Yat-Sen University in Guangzhou, China, used CRISPR (clustered regularly interspaced palindromic repeats), a technique that relies on “cellular machinery” used by bacteria in defense against viruses.
This machinery is copied and altered to create specific gene-editing complexes, which include the wonder enzyme Cas9. The enzyme works its way into the DNA and can be used to alter the molecule from the inside. The combination is attached to an RNA guide that takes the gene-editing complex to its target, telling Cas9 where to operate.
Use of the CRISPR technique is not necessarily relegated to the likes of cash-flush university research operations, according to a report by Business Insider.
"You could conceivably set up a CRISPR lab for $2,000,” he said, according to Business Insider.
Other top researchers have echoed this sentiment.
"Any scientist with molecular biology skills and knowledge of how to work with [embryos] is going to be able to do this,” Jennifer Doudna, a biologist at the University of California, Berkeley, recently told MIT Tech Review, which reported that Doudna co-discovered how to edit genetic code using CRISPR in 2012.
Last week, the Sun Yat-Sen University research team said it attempted to cure a gene defect that causes beta-thalassemia (a genetic blood disorder that could lead to severe anemia, poor growth, skeletal abnormalities and even death) by editing the germ line. For that purpose they used a gene-editing technique based on injecting non-viable embryos with a complex, which consists of a protective DNA element obtained from bacteria and a specific protein.
"I suspect this week will go down as a pivotal moment in the history of medicine," wrote science journalist Carl Zimmer for National Geographic.
Response to the new research has been mixed. Some experts say the gene editing could help defeat genetic diseases even before birth. Others expressed concern.
“At present, the potential safety and efficacy issues arising from the use of this technology must be thoroughly investigated and understood before any attempts at human engineering are sanctioned, if ever, for clinical testing,” a group of scientists, including some who had worked to develop CRISPR, warned in Science magazine.
Meanwhile, the director of the US National Institutes for Health (NIH) said the agency would not fund such editing of human embryo genes.
“Research using genomic editing technologies can and are being funded by NIH,” Francis Collins said Wednesday. “However, NIH will not fund any use of gene-editing technologies in human embryos. The concept of altering the human germline in embryos for clinical purposes ... has been viewed almost universally as a line that should not be crossed.”
Although the discovery of CRISPR sequences dates back to 1987 – when it was first used to cure bacteria of viruses – its successes in higher animals and humans were only achieved in 2012-13, when scientists achieved a revolution by combining the resulting treatment system with Cas9 for the first time.
On April 17, the MIT’s Broad Institute announced that has been awarded the first-ever patent for working with the Crisp-Cas9 system.
The institute’s director, Eric Lander, sees the combination as “an extraordinary, powerful tool. The ability to edit a genome makes it possible to discover the biological mechanisms underlying human biology.”
The system’s advantage over other methods is in that it can also target several genes at the same time, working its way through tens of thousands of so-called 'guide' RNA sequences that lead them to the weapon to its DNA targets.
Meanwhile, last month in the UK, a healthy baby was born from an embryo screened for genetic diseases, using karyomapping, a breakthrough testing method that allows doctors to identify about 60 debilitating hereditary disorders.
Excerpt from huffingtonpost.com
By Amanda MacMillan
You're probably all too aware of the major sources of stress in your life -- money, your terrible commute, the construction workers who start jackhammering at 5 a.m. But stress and anxiety don't have to just come from obvious or even negative sources. "There are plenty of chronic strains and low-grade challenges that don't necessarily overwhelm you in the moment, but almost take more of a toll in the long run," says Scott Schieman, Ph.D., professor of sociology at the University of Toronto. These are some of unexpected reasons why you might feel anxious or agitated. By recognizing them for what they are, says Schieman, you can better prepare to cope.
1. Your Significant Other
Even if you have a blissfully happy relationship with your live-in partner or spouse, you're both bound to do things that get on each other's nerves. "Early in the relationship, it's usually about space and habits -- like whether you squeeze the toothpaste from the middle or the bottom of the tube," says Ken Yeager, Ph.D., associate professor of psychiatry at the Ohio State University Wexner Medical Center. "Later on, you might clash over parenting style or financial issues, and finding a unified front to face these issues together." So what's the key to surviving and thriving in your life together? Finding balance, says Yeager: spending the right amount of time together (not too much and not too little), making compromises, keeping communication open and honest, and remembering to acknowledge what you love about each other on a daily basis.
2. Everyday Annoyances
We're told not to sweat the small stuff, but sometimes it's the little things that have the biggest impact on our mood: the never-ending phone calls with your insurance company, the rude cashier at the grocery store, the 20 minutes you lose looking for a parking space. "We let these things bother us because they trigger unconscious fears," says Yeager -- fears of being seen as irresponsible, of being bullied or embarrassed, or of being late all the time, for example. "Sometimes you need to take a step back and realize that you're doing the best you can given the circumstances."
3. Other People's Stress
Stress is contagious, according to a 2014 German study: In a series of experiments, most participants who simply observed others completing a stressful task experienced an increase themselves in production of the stress hormone cortisol -- a phenomenon known as empathic stress. You can also experience stress when someone you know is affected by a traumatic event, like a car crash or a chronic illness. "You start to worry, 'Oh my gosh, could that happen to me?'," says Yeager. "We tend not to think about these things until they hit close to home."
4. Social Media
It may seem like Facebook is the only way you keep up with the friends you don't see regularly -- which, during particularly busy times, can be just about all of them. The social network also has a downside, according to a 2015 study from the Pew Research Center: It can make you aware of stressful situations in your friends' lives, which in turn can add more stress to your life. The Pew report didn't find that social media users, overall, had higher levels of stress, but previous studies have suggested that frequent social-media use can be associated with negative body image and prolonged breakup pain.
5. Distraction
A distraction can be a good thing then when it takes your mind off of a stressful situation or difficult decision, like when you take a break from work to meet a friend for lunch. But it works the other way, as well: When you're so busy thinking about something else that you can't enjoy what's going on around you, that kind of distraction can be a recipe for stress. Practicing mindfulness gives you brain the refresh it needs, says Richard Lenox, director of the Student Counseling Center at Texas Tech University. Paying full attention to your surroundings when you're walking and driving can help, he adds. "Stress and anxiety tend to melt away when our mind is focused on the present."
6. Your Childhood
Traumatic events that happened when you were a kid can continue to affect your stress levels and overall health into adulthood. A 2014 University of Wisconsin-Madison study found that these childhood experiences may actually change parts of the brain responsible for processing stress and emotion. The way you were raised can also have a lasting impact on your everyday angst, suggests a 2014 Johns Hopkins University study. Researchers found that children of parents with social anxiety disorders are more likely to develop "trickle-down anxiety" -- not simply because of their genes, but because of their parents' behaviors toward them such as a lack of warmth and emotion, or high levels of criticism and doubt.
7. Tea And Chocolate
You probably know to take it easy on the coffee when you're already feeling on edge. "Caffeine is always going to make stress worse," says Yeager. But you may not think as much about drinking several cups of tea at once, or chowing down on a bar of dark chocolate -- both of which can contain nearly as much caffeine as a cup of joe. "Chocolate is a huge caffeine source," says Yeager. "I know people who don't drink coffee but they'll eat six little candy bars in a two-hour period because they want the same kind of jolt." Too much caffeine, in any form, can cause problems with sleep, digestion, and irritability.
8. Your Expectations
When things don't go the way you've planned, do you tend to get upset and act defensively, or do you roll with the punches and set off on a new plan? If it's the former, you could be contributing to a mindset of pessimism and victimization that will slowly wear you down, even when things may not be as bad as they seem. "Your level of serenity is inversely proportionate to your expectations," says Yeager. That doesn't mean you shouldn't set ambitious goals for yourself or settle for less than what you want, of course, but being realistic about what's truly possible is important, as well.
9. Your Reaction To Stress
If you tend to deal with stressful situations by working long hours, skipping your workouts, and bingeing on junk food, we've got some bad news: You're only making it worse. "We know that physical activity and healthy foods will help your body better deal with stress, and yet we often avoid them when we need them the most," says Yeager. "People really need to think about this downward spiral we get into and work harder to counteract it."
10. Multitasking
Think you're being super efficient by tackling four tasks at once? Chances are you're not -- and it's only decreasing your productivity while increasing your stress. A 2012 University of Irvine study, for example, found that people who responded to emails all day long while also trying to get their work done experienced more heart-rate variability (an indicator of mental stress) than those who waited to respond to all of their emails at one time. Focusing on one task at a time can ensure that you're doing that job to the best of your abilities and getting the most out of it, so you won't have to worry about or go back and fix it later, says Schieman. And don't worry: You'll have enough time to do it all. In fact, you may discover you have more time than you thought.
11. Your Favorite Sport
Watching a tight game of college hoops can stress you out -- even if your alma mater wins. "The body doesn't distinguish between 'bad' stress from life or work and 'good' stress caused by game-day excitement," says Jody Gilchrist, a nurse practitioner at the University of Alabama at Birmingham’s Heart and Vascular Clinic. Watching sports can even trigger the body's sympathetic nervous system, releasing adrenaline and reducing blood flow to the heart. Those temporary consequences aren't usually anything to be concerned about, but over time, chronic stress can lead to high blood pressure and increased disease risk. And, of course, it doesn't help if you're adding alcohol and binge-eating to a situation that's already stressful on your body. You may not be able to control the outcome of the game, says Gilchrist, but you can limit its effects on your own body.
12. Digital Devices
Whether you're using it for work or play, technology may play a large role in your mental health, says Yeager. Using computers or e-readers too close to bedtime could lead to sleep problems, he says, and spending too much time virtually socializing can make real-life interactions seem extra stressful. (Plus, texting doesn't trigger the same feel-good hormones as face-to-face talk does.) Then there's the dreaded "work creep," says Schieman, when smartphones allow employees to be tethered to their jobs, even during off-hours. "People say they're only going to check email for an hour while they're on vacation, but the problem with email is that they're filled with responsibilities, new tasks, and dilemmas that are going to be hard to compartmentalize and put out of your head once that hour is up."
13. Your (Good) Health
While it may not be as stressful as having a chronic illness or getting bad news at the doctor's office, even people in the best shape of their lives worry about their bodies, their diets, and their fitness levels. In fact, people who take healthy living to an extreme may experience some rather unhealthy side effects. People who follow low-carb diets, for example, are more likely to report being sad or stressed out, while those on any kind of restrictive meal plan may feel more tired than usual. And it's not unheard of for someone to become obsessed with healthy eating (known as orthorexia) or working out (gymorexia). Like any form of perfectionism, these problems can be stressful at best, and extremely dangerous at worst.
14. Housework
Does folding laundry help you feel calm, or does it make your blood boil? If you're in a living situation where you feel you're responsible for an unfair share of work, even chores you once enjoyed may start to feel like torture. "Dividing up housework and parenting responsibilities can be tricky, especially if both partners work outside the home," says Schieman. "And whether you define that division of labor as equal or unequal can really change your attitude toward it."
15. Uncertainty
Stress can be defined as any perceived or actual threat, says Yeager, so any type of doubt that's looming over you can contribute to your anxiety levels on a daily basis. "When you know something could change at any minute, you always have your guard up and it's hard to just relax and enjoy anything." Financial uncertainty may be the most obvious stressor -- not being sure if you'll keep your job during a round of layoffs, or not knowing how you'll pay your credit card bill. Insecurities in other areas of life, like your relationship or your housing status, can eat away at you too.
16. Your Pet
No matter how much you love your furry friends, there's no question that they add extra responsibility to your already full plate. Even healthy animals need to be fed, exercised, cleaned up after, and given plenty of attention on a regular basis -- and unhealthy ones can be a whole other story. "Pets can be the most positive source of unconditional love, but at the same time they require an extreme amount of energy," says Yeager. People also tend to underestimate the stress they'll experience when they lose a pet. "I've had people in my office tell me they cried more when their dog died than when their parent died. It's a very emotional connection."
17. Your Education
Having a college degree boosts your odds of landing a well-paying job, so although you're less likely to suffer from money-related anxiety, your education can bring on other types of stress, according to a 2014 study by Schieman and his University of Toronto colleagues. His research found that highly educated people were more likely to be stressed out thanks to job pressures, being overworked, and conflicts between work and family. "Higher levels of authority come with a lot more interpersonal baggage, such as supervising people or deciding whether they get promotions," says Schieman. "With that type of responsibility, you start to take things like incompetency and people not doing their jobs more personally, and it bothers you more."
Excerpt from independent.co.uk
By Jordan Gaines Lewis
In neuroscience, food is something we call a “natural reward.” In order for us to survive as a species, things like eating, having sex and nurturing others must be pleasurable to the brain so that these behaviours are reinforced and repeated.
Evolution has resulted in the mesolimbic pathway, a brain system that deciphers these natural rewards for us. When we do something pleasurable, a bundle of neurons called the ventral tegmental area uses the neurotransmitter dopamine to signal to a part of the brain called the nucleus accumbens. The connection between the nucleus accumbens and our prefrontal cortex dictates our motor movement, such as deciding whether or not to taking another bite of that delicious chocolate cake. The prefrontal cortex also activates hormones that tell our body: “Hey, this cake is really good. And I’m going to remember that for the future.”Not all foods are equally rewarding, of course. Most of us prefer sweets over sour and bitter foods because, evolutionarily, our mesolimbic pathway reinforces that sweet things provide a healthy source of carbohydrates for our bodies. When our ancestors went scavenging for berries, for example, sour meant “not yet ripe,” while bitter meant “alert – poison!”
Fruit is one thing, but modern diets have taken on a life of their own. A decade ago, it was estimated that the average American consumed 22 teaspoons of added sugar per day, amounting to an extra 350 calories; it may well have risen since then. A few months ago, one expert suggested that the average Briton consumes 238 teaspoons of sugar each week.
Today, with convenience more important than ever in our food selections, it’s almost impossible to come across processed and prepared foods that don’t have added sugars for flavour, preservation, or both.
These added sugars are sneaky – and unbeknown to many of us, we’ve become hooked. In ways that drugs of abuse – such as nicotine, cocaine and heroin – hijack the brain’s reward pathway and make users dependent, increasing neuro-chemical and behavioural evidence suggests that sugar is addictive in the same way, too.
Sugar addiction is real
Anyone who knows me also knows that I have a huge sweet tooth. I always have. My friend and fellow graduate student Andrew is equally afflicted, and living in Hershey, Pennsylvania – the “Chocolate Capital of the World” – doesn’t help either of us. But Andrew is braver than I am. Last year, he gave up sweets for Lent. “The first few days are a little rough,” Andrew told me. “It almost feels like you’re detoxing from drugs. I found myself eating a lot of carbs to compensate for the lack of sugar.”There are four major components of addiction: bingeing, withdrawal, craving, and cross-sensitisation (the notion that one addictive substance predisposes someone to becoming addicted to another). All of these components have been observed in animal models of addiction – for sugar, as well as drugs of abuse.
A typical experiment goes like this: rats are deprived of food for 12 hours each day, then given 12 hours of access to a sugary solution and regular chow. After a month of following this daily pattern, rats display behaviours similar to those on drugs of abuse. They’ll binge on the sugar solution in a short period of time, much more than their regular food. They also show signs of anxiety and depression during the food deprivation period. Many sugar-treated rats who are later exposed to drugs, such as cocaine and opiates, demonstrate dependent behaviours towards the drugs compared to rats who did not consume sugar beforehand.
Like drugs, sugar spikes dopamine release in the nucleus accumbens. Over the long term, regular sugar consumption actually changes the gene expression and availability of dopamine receptors in both the midbrain and frontal cortex. Specifically, sugar increases the concentration of a type of excitatory receptor called D1, but decreases another receptor type called D2, which is inhibitory. Regular sugar consumption also inhibits the action of the dopamine transporter, a protein which pumps dopamine out of the synapse and back into the neuron after firing.
In short, this means that repeated access to sugar over time leads to prolonged dopamine signalling, greater excitation of the brain’s reward pathways and a need for even more sugar to activate all of the midbrain dopamine receptors like before. The brain becomes tolerant to sugar – and more is needed to attain the same “sugar high.”
Sugar withdrawal is also real
Although these studies were conducted in rodents, it’s not far-fetched to say that the same primitive processes are occurring in the human brain, too. “The cravings never stopped, [but that was] probably psychological,” Andrew told me. “But it got easier after the first week or so.”In a 2002 study by Carlo Colantuoni and colleagues of Princeton University, rats who had undergone a typical sugar dependence protocol then underwent “sugar withdrawal.” This was facilitated by either food deprivation or treatment with naloxone, a drug used for treating opiate addiction which binds to receptors in the brain’s reward system. Both withdrawal methods led to physical problems, including teeth chattering, paw tremors, and head shaking. Naloxone treatment also appeared to make the rats more anxious, as they spent less time on an elevated apparatus that lacked walls on either side.
Similar withdrawal experiments by others also report behaviour similar to depression in tasks such as the forced swim test. Rats in sugar withdrawal are more likely to show passive behaviours (like floating) than active behaviours (like trying to escape) when placed in water, suggesting feelings of helplessness.
A new study published by Victor Mangabeira and colleagues in this month’s Physiology & Behavior reports that sugar withdrawal is also linked to impulsive behaviour. Initially, rats were trained to receive water by pushing a lever. After training, the animals returned to their home cages and had access to a sugar solution and water, or just water alone. After 30 days, when rats were again given the opportunity to press a lever for water, those who had become dependent on sugar pressed the lever significantly more times than control animals, suggesting impulsive behaviour.
These are extreme experiments, of course. We humans aren’t depriving ourselves of food for 12 hours and then allowing ourselves to binge on soda and doughnuts at the end of the day. But these rodent studies certainly give us insight into the neuro-chemical underpinnings of sugar dependence, withdrawal, and behaviour.
Through decades of diet programmes and best-selling books, we’ve toyed with the notion of “sugar addiction” for a long time. There are accounts of those in “sugar withdrawal” describing food cravings, which can trigger relapse and impulsive eating. There are also countless articles and books about the boundless energy and new-found happiness in those who have sworn off sugar for good. But despite the ubiquity of sugar in our diets, the notion of sugar addiction is still a rather taboo topic.
Are you still motivated to give up sugar? You might wonder how long it will take until you’re free of cravings and side-effects, but there’s no answer – everyone is different and no human studies have been done on this. But after 40 days, it’s clear that Andrew had overcome the worst, likely even reversing some of his altered dopamine signalling. “I remember eating my first sweet and thinking it was too sweet,” he said. “I had to rebuild my tolerance.”
And as regulars of a local bakery in Hershey – I can assure you, readers, that he has done just that.
Jordan Gaines Lewis is a Neuroscience Doctoral Candidate at Penn State College of Medicine
Excerpt from seattletimes.com
A decision to list the captive orca Lolita for federal protection is expected to set the stage for a lawsuit from advocates seeking the whale’s release.
By Hal Bernton
Seattle Times staff reporter
The National Oceanic and Atmospheric Administration (NOAA) announced Wednesday the decision to list Lolita as part of the southern resident killer whales of Puget Sound, which already are considered endangered under the federal act.
Whale activists, who petitioned for this status, have long campaigned for Lolita’s return to Puget Sound. They hope the listing will provide a stronger legal case to release Lolita than did a previous lawsuit that centered on alleged violations of the federal Animal Welfare Act.
“This gives leverage under a much stronger law,” said Howard Garrett of the Whidbey Island based Orca Network, which hopes a San Juan Island cove will one day serve as the site for Lolita to re-enter the wild.
NOAA Fisheries officials on Wednesday described their decision in narrow terms, which set no broader precedents. It does not address whether Lolita should be released from the Seaquarium.
“This is a listing decision,” said Will Stelle, the NOAA Fisheries regional administrator for the West Coast. “It is not a decision to free Lolita.”
Aquarium officials have repeatedly said they have no intention of releasing the orca.
“Lolita has been part of the Miami Seaquarium family for 44 years,” said Andrew Hertz, Seaquarium general manager, in a statement.
“Lolita is healthy and thriving in her home where she shares habitat with Pacific white-sided dolphins. There is no scientific evidence that ... Lolita could survive in a sea pen or the open waters of the Pacific Northwest, and we are not willing to treat her life as an experiment.”
Orcas, also known as killer whales, are found in many of the world’s oceans. The southern resident population, which spends several months each year in Puget Sound, is the only group listed in the U.S. under the Endangered Species.
The three pods in the population were reduced by captures by marine parks between 1965 and 1975, NOAA says. Among them was a roundup in Penn Cove where seven whales were captured, including Lolita.
The southern resident pods now number fewer than 80. Possible causes for the decline are reduced prey, pollutants that could cause reproductive problems and oil spills, according to NOAA Fisheries.
Under the Endangered Species Act, it is illegal to cause a “take” of a protected orca, which includes harming or harassing them.
Wednesday, NOAA officials said holding an animal captive, in and of itself, does not constitute a take.
Orca activists are expected to argue in their lawsuit that Lolita's cramped conditions result in a prohibited take.
There is “rising public scorn for the whole idea of performing orcas,” said Garrett, who hopes Seaquarium will decide to release Lolita without a court order.
But NOAA officials still have concerns about releasing captive whales, and any plan to move or release Lolita would require “rigorous scientific review,” the agency said in a statement.
The concerns include the possibility of disease transmission, the ability of a newly released orca to find food and behavior patterns from captivity that could impact wild whales.
NOAA said previous attempts to release captive orcas and dolphins have often been unsuccessful and some have ended in death.
Garrett said the plan for Lolita calls for her to be taken to a netted area of the cove, which could be enlarged later. She would be accompanied by familiar trainers who could “trust and reassure her every bit of the way,” he said.
The controversy over releasing captive whales has been heightened by the experience of Keiko, a captive orca that starred in the 1993 movie “Free Willy,” about a boy who pushed for the release of a whale.
In 1998, Keiko was brought back to his native waters off Iceland to reintroduce him to life in the wild. That effort ended in 2003 when he died in a Norwegian fjord.
Garrett, who visited Keiko in Iceland in 1999, said he was impressed by the reintroduction effort, and that there was plenty of evidence that Keiko was able to catch fish on his own.
“The naysayers predicted that as soon as he got into the (Icelandic) waters he would die, and wild orcas would kill him,” Garrett said. “He proved that 180-degrees wrong. He loved it.”
Mark Simmons, who for two years served as director of animal husbandry for the Keiko-release effort, has a different view. He says Keiko never was able to forage for fish on his own, and that he continued to seek out human contact at every opportunity.
Simmons wrote a book called “Killing Keiko,” that accuses the release effort of leading to a long slow death for the orca, which he says lacked food and then succumbed to an infection.
“It’s not really the fact that Keiko died, but how he died,” Garrett said Wednesday.
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In this infrared image, stellar winds from a giant star cause interstellar dust to form ripples. There's a whole lot of dust—which contains oxygen, carbon, iron, nickel, and all the other elements—out there, and eventually some of it finds its way into our bodies. Photograph by NASA, JPL-Caltech |
We have stardust in us as old as the universe—and some that may have landed on Earth just a hundred years ago.
Excerpt from National Geographic
By Simon Worrall
Astrophysics and medical pathology don't, at first sight, appear to have much in common. What do sunspots have to do with liver spots? How does the big bang connect with cystic fibrosis?
Book jacket courtesy of schrijver+schrijver
Astrophysicist Karel Schrijver, a senior fellow at the Lockheed Martin Solar and Astrophysics Laboratory, and his wife, Iris Schrijver, professor of pathology at Stanford University, have joined the dots in a new book, Living With the Stars: How the Human Body Is Connected to the Life Cycles of the Earth, the Planets, and the Stars.
Talking from their home in Palo Alto, California, they explain how everything in us originated in cosmic explosions billions of years ago, how our bodies are in a constant state of decay and regeneration, and why singer Joni Mitchell was right.
"We are stardust," Joni Mitchell famously sang in "Woodstock." It turns out she was right, wasn't she?
Iris: Was she ever! Everything we are and everything in the universe and on Earth originated from stardust, and it continually floats through us even today. It directly connects us to the universe, rebuilding our bodies over and again over our lifetimes.
That was one of the biggest surprises for us in this book. We really didn't realize how impermanent we are, and that our bodies are made of remnants of stars and massive explosions in the galaxies. All the material in our bodies originates with that residual stardust, and it finds its way into plants, and from there into the nutrients that we need for everything we do—think, move, grow. And every few years the bulk of our bodies are newly created.
Can you give me some examples of how stardust formed us?
Karel: When the universe started, there was just hydrogen and a little helium and very little of anything else. Helium is not in our bodies. Hydrogen is, but that's not the bulk of our weight. Stars are like nuclear reactors. They take a fuel and convert it to something else. Hydrogen is formed into helium, and helium is built into carbon, nitrogen and oxygen, iron and sulfur—everything we're made of. When stars get to the end of their lives, they swell up and fall together again, throwing off their outer layers. If a star is heavy enough, it will explode in a supernova.
So most of the material that we're made of comes out of dying stars, or stars that died in explosions. And those stellar explosions continue. We have stuff in us as old as the universe, and then some stuff that landed here maybe only a hundred years ago. And all of that mixes in our bodies.
Stars are being born and stars are dying in this infrared snapshot of the heavens. You and I—we come from stardust.
Photograph by NASA, JPL-Caltech, University of Wisconsin
Your book yokes together two seemingly different sciences: astrophysics and human biology. Describe your individual professions and how you combined them to create this book.
Iris: I'm a physician specializing in genetics and pathology. Pathologists are the medical specialists who diagnose diseases and their causes. We also study the responses of the body to such diseases and to the treatment given. I do this at the level of the DNA, so at Stanford University I direct the diagnostic molecular pathology laboratory. I also provide patient care by diagnosing inherited diseases and also cancers, and by following therapy responses in those cancer patients based on changes that we can detect in their DNA.
Our book is based on many conversations that Karel and I had, in which we talked to each other about topics from our daily professional lives. Those areas are quite different. I look at the code of life. He's an astrophysicist who explores the secrets of the stars. But the more we followed up on our questions to each other, the more we discovered our fields have a lot more connections than we thought possible.
Karel: I'm an astrophysicist. Astrophysicists specialize in all sorts of things, from dark matter to galaxies. I picked stars because they fascinated me. But no matter how many stars you look at, you can never see any detail. They're all tiny points in the sky.
So I turned my attention to the sun, which is the only star where we can see what happens all over the universe. At some point NASA asked me to lead a summer school for beginning researchers to try to create materials to understand the things that go all the way from the sun to the Earth. I learned so many things about these connections I started to tell Iris. At some point I thought: This could be an interesting story, and it dawned on us that together we go all the way, as she said, from the smallest to the largest. And we have great fun doing this together.
We tend to think of our bodies changing only slowly once we reach adulthood. So I was fascinated to discover that, in fact, we're changing all the time and constantly rebuilding ourselves. Talk about our skin.
Iris: Most people don't even think of the skin as an organ. In fact, it's our largest one. To keep alive, our cells have to divide and grow. We're aware of that because we see children grow. But cells also age and eventually die, and the skin is a great example of this.
It's something that touches everything around us. It's also very exposed to damage and needs to constantly regenerate. It weighs around eight pounds [four kilograms] and is composed of several layers. These layers age quickly, especially the outer layer, the dermis. The cells there are replaced roughly every month or two. That means we lose approximately 30,000 cells every minute throughout our lives, and our entire external surface layer is replaced about once a year.
Very little of our physical bodies lasts for more than a few years. Of course, that's at odds with how we perceive ourselves when we look into the mirror. But we're not fixed at all. We're more like a pattern or a process. And it was the transience of the body and the flow of energy and matter needed to counter that impermanence that led us to explore our interconnectedness with the universe.
You have a fascinating discussion about age. Describe how different parts of the human body age at different speeds.
Iris: Every tissue recreates itself, but they all do it at a different rate. We know through carbon dating that cells in the adult human body have an average age of seven to ten years. That's far less than the age of the average human, but there are remarkable differences in these ages. Some cells literally exist for a few days. Those are the ones that touch the surface. The skin is a great example, but also the surfaces of our lungs and the digestive tract. The muscle cells of the heart, an organ we consider to be very permanent, typically continue to function for more than a decade. But if you look at a person who's 50, about half of their heart cells will have been replaced.
Our bodies are never static. We're dynamic beings, and we have to be dynamic to remain alive. This is not just true for us humans. It's true for all living things.
A figure that jumped out at me is that 40,000 tons of cosmic dust fall on Earth every year. Where does it all come from? How does it affect us?
Karel: When the solar system formed, it started to freeze gas into ice and dust particles. They would grow and grow by colliding. Eventually gravity pulled them together to form planets. The planets are like big vacuum cleaners, sucking in everything around them. But they didn't complete the job. There's still an awful lot of dust floating around.
When we say that as an astronomer, we can mean anything from objects weighing micrograms, which you wouldn't even see unless you had a microscope, to things that weigh many tons, like comets. All that stuff is still there, being pulled around by the gravity of the planets and the sun. The Earth can't avoid running into this debris, so that dust falls onto the Earth all the time and has from the very beginning. It's why the planet was made in the first place.
Nowadays, you don't even notice it. But eventually all that stuff, which contains oxygen and carbon, iron, nickel, and all the other elements, finds its way into our bodies.
When a really big piece of dust, like a giant comet or asteroid, falls onto the Earth, you get a massive explosion, which is one of the reasons we believe the dinosaurs became extinct some 70 million years ago. That fortunately doesn't happen very often. But things fall out of the sky all the time. [Laughs]
Many everyday commodities we use also began their existence in outer space. Tell us about salt.
Karel: Whatever you mention, its history began in outer space. Take salt. What we usually mean by salt is kitchen salt. It has two chemicals, sodium and chloride. Where did they come from? They were formed inside stars that exploded billions of years ago and at some point found their way onto the Earth. Stellar explosions are still going on today in the galaxy, so some of the chlorine we're eating in salt was made only recently.
You study pathology, Iris. Is physical malfunction part of the cosmic order?
Iris: Absolutely. There are healthy processes, such as growth, for which we need cell division. Then there are processes when things go wrong. We age because we lose the balance between cell deaths and regeneration. That's what we see in the mirror when we age over time. That's also what we see when diseases develop, such as cancers. Cancer is basically a mistake in the DNA, and because of that the whole system can be derailed. Aging and cancer are actually very similar processes. They both originate in the fact that there's a loss of balance between regeneration and cell loss.
Cystic fibrosis is an inherited genetic disease. You inherit an error in the DNA. Because of that, certain tissues do not have the capability to provide their normal function to the body. My work is focused on finding changes in DNA in different populations so we can understand better what kinds of mutations are the basis of that disease. Based on that, we can provide prognosis. There are now drugs that target specific mutations, as well as transplants, so these patients can have a much better life span than was possible 10 or 20 years ago.
How has writing this book changed your view of life—and your view of each other?
Karel: There are two things that struck me, one that I had no idea about. The first is what Iris described earlier—the impermanence of our bodies. As a physicist, I thought the body was built early on, that it would grow and be stable. Iris showed me, over a long series of dinner discussions, that that's not the way it works. Cells die and rebuild all the time. We're literally not what were a few years ago, and not just because of the way we think. Everything around us does this. Nature is not outside us. We are nature.
As far as our relationship is concerned, I always had a great deal of respect for Iris, and physicians in general. They have to know things that I couldn't possibly remember. And that's only grown with time.
Iris: Physics was not my favorite topic in high school. [Laughs] Through Karel and our conversations, I feel that the universe and the world around us has become much more accessible. That was our goal with the book as well. We wanted it to be accessible and understandable for anyone with a high school education. It was a challenge to write it that way, to explain things to each other in lay terms. But it has certainly changed my view of life. It's increased my sense of wonder and appreciation of life.
In terms of Karel's profession and our relationship, it has inevitably deepened. We understand much better what the other person is doing in the sandboxes we respectively play in. [Laughs]
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