Tag: foundation (page 3 of 8)

Researchers make 32 differently-shaped DNA crystals – is this the future of nanotech?



Researchers have achieved 32 different–shaped crystal structures using the DNA–brick self–assembly method. (Photo : Harvard’s Wyss Institute)

Excerpt from
zmescience.com 

A team at Harvard’s Wyss Institute for Biologically Inspired Engineering demonstrated the latest advances in programmable DNA self-assembly by crystallizing 32 structures with precisely prescribed depths and complex 3D features. The DNA crystals could potentially be used as the basis of a programmable material platform that would allow scientists to build extremely precise and complex structures rivaling the complexity of many molecular machines we see in nature – all from the bottom up!

Nanotechnology like Lego

For the past twenty years or so, there’s been a lot of interest shown into designing large DNA crystals of various desired shapes by exploiting DNA’s inherent ability to self-assemble. We’re recently beginning to see the fruits of this labor, first in 2012 when the same team described their “DNA-brick self-assembly” method that allowed them to build more than 100 3D complex nanostructures about the size of viruses. The 32 designs reported in this latest research are 1000 times larger, close to the size of a speck of dust, which makes them closer to applicable scale where they can be used practically.

With conventional methods of DNA assembly, the resulting design tends to become more and more imperfect as you scale the design because at each step there’s a risk of error. The technique developed at Harvard is different because since it uses short, synthetic strands of DNA that work like interlocking Lego® bricks to build complex structures – it’s a modular design. Each structure first starts off as a computer model of a molecular cube (the master canvas), then individual DNA bricks are removed or added independently until a desired shape is met. These bricks bind to as many as four neighboring strands or bricks. Thus, two bricks connect to one another at a 90-degree angle to form a 3D shape, just like a pair of two-stud Lego bricks. Each individual brick is coded in such a way that they self-assemble in a desired 3-D shape. What’s fantastic is that this method allows for intricate shapes to built on an extremely tiny scale opening up a slew of applications. For instance, a cube built up from 1,000 such bricks (10 by 10 by 10) measures just 25 nanometers in width – thousands of times smaller than the width of a human hair!
“Therein lies the key distinguishing feature of our design strategy—its modularity,” said co-lead author Yonggang Ke, Ph.D., formerly a Wyss Institute Postdoctoral Fellow and now an assistant professor at the Georgia Institute of Technology and Emory University. “The ability to simply add or remove pieces from the master canvas makes it easy to create virtually any design.”

Precision controlled DNA

Most importantly, this modularity allows precision control of the structure’s depth. This is the first time that anyone has been able to design crystal depth with nanometer precision, up to 80 nm, as opposed to  two-dimensional DNA lattices which are typically single-layer structures with only 2 nm depth.
“DNA crystals are attractive for nanotechnology applications because they are comprised of repeating structural units that provide an ideal template for scalable design features”, said co-lead author graduate student Luvena Ong.

 “Peng’s team is using the DNA-brick self-assembly method to build the foundation for the new landscape of DNA nanotechnology at an impressive pace,” said Wyss Institute Founding Director Don Ingber, M.D., Ph.D. “What have been mere visions of how the DNA molecule could be used to advance everything from the semiconductor industry to biophysics are fast becoming realities.”

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NASA Brings Scientists & Theologians Together To Prepare World For Extraterrestrial Contact

Arjun Walia, Collective-EvolutionA couple of months ago top U.S. astronomers gathered in front of congress to let them know that extraterrestrial life exists without question. Their main argument was the size of the universe, emphasizing that there are trillions of stars out there, with one in every five most likely harboring an Earth-like planet. It’s also important to keep in mind that planets do not have to be “Earth-like” in order to harbor life. You can read mor [...]

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7 Types of Non-Believers Who Don’t Need Religion

Valerie Tarico, AlterNetReligious labels help shore up identity. So what are some of the things non-believers can call themselves?Catholic, born-again, Reformed, Jew, Muslim, Shiite, Sunni, Hindu, Sikh, Buddhist…religions give people labels. The downside can be tribalism, an assumption that insiders are better than outsiders, that they merit more compassion, integrity and generosity or even that violence toward “infidels” is acceptable. But the upside is that religious o [...]

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The Light Side of the Dark Night of the Soul

by Kim Hutchinson Clayhut Healing CentreThe phenomenon known as the Dark Night of the Soul is something which many spiritual seekers experience on their journey to re-enlightenment. It can be a painful and frightening process, but it can also be liberating and empowering. It all depends on your perspective and your ability to remain detached. Peeling the Onion The word ‘night’ is misleading. This is a process, and thankfully so. I doubt you would want to experience [...]

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India’s Mars mission a step closer to success with engine test

India's Polar Satellite Launch Vehicle (PSLV-C25), carrying the Mars orbiter, blasts off from the Satish Dhawan Space Centre in Sriharikota, about 100 km (62 miles) north of the southern Indian city of Chennai November 5, 2013. REUTERS/B...

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Cosmic dust may have distorted cosmic inflation breakthrough


The 10-meter South Pole Telescope and the BICEP (Background Imaging of Cosmic Extragalactic Polarization) Telescope at Amundsen-Scott South Pole Station, which detected evidence of gravitational waves, is seen against the night sky with the Milky Way in this National Science Foundation picture taken in August 2008.

By Ben P. Stein, Inside Science

Harvard researchers rocked the science community last March with an apparent discovery of gravitational ripples that gave credence to cosmic inflation theory – a finding that met as much skepticism as enthusiasm. Now, further analysis raises more doubts.


"Extraordinary claims require extraordinary evidence." This phrase, popularized by the late Carl Sagan, kept going through my head on March 17, the day that researchers involved with BICEP2, a telescope in Antarctica, made a big announcement at the Harvard-Smithsonian Center for Astrophysics in Cambridge, Massachusetts.

The researchers reported that BICEP2 detected gravitational waves from the first moments after the big bang, a feat, which if confirmed, would open up a new field of study and would surely be recognized in a future Nobel Prize.

Gravitational waves are ripples in space and time. They're created when any object with mass accelerates. However, they're extremely weak, making them very hard to detect directly. Even for the most massive and cataclysmic events, such as the collision of two black holes, their effects, observed from Earth, are very hard to detect.

If you're looking for a detectable gravitational wave signal, what bigger event can there be than cosmic inflation? According to inflation theory, the universe multiplied its size by as much as 10 trillion trillion trillion times in the first fractions of a second after the big bang.  Inflation would have generated lots of gravitational waves. In turn, gravitational waves can subtly change the properties of light that they pass through. Specifically, they can slightly affect the polarization of light, the direction in which light's electric fields vibrate. The universe's rapid expansion during inflation would have amplified the waves' imprint on the early light in the universe.

The state-of-the-art BICEP2 experiment, which uses super-sensitive superconducting sensors, could detect tiny changes in polarization in the cosmic microwave background, the very first light released in the universe, which is still reaching us today. The BICEP2 researchers reported a very high polarization signal, known as B-mode polarization after its characteristics, in the cosmic microwave background, which they interpreted as a strong gravitational wave signal in the early universe.

Detecting this polarization signal was a striking result, announced in a series of scientific talks and a press conference shortly after a preprint of the paper was posted online. Notice these last two points: announced at a press conference, and a preprint posted online. A preprint is a written paper that has not been formally reviewed by independent peers or published in a scientific journal.

Nonetheless, scientists and reporters alike reported excitement over the results. If true, they would provide the greatest experimental support yet of cosmic inflation, and the first direct detection of gravitational waves. Previously, gravitational waves have been detected indirectly, such as in observations of pairs of stars falling towards each other: they were losing energy in the form of gravitational waves.

On the day of the BICEP2 announcement, and for many days afterward, people were largely accepting the results as correct and already jumping to the implications of the BICEP2 results for what appeared to be a new era of gravitational-wave cosmology.
In writing my story for Inside Science News Service, I was fortunate to get an early voice of skepticism from David Spergel, a theoretical cosmologist at Princeton University in New Jersey. He commented:

"Given the importance of this result, my starting point is to be skeptical. Most importantly, there are several independent experimental groups that will test this result in the next year."
Spergel explained that the new gravitational wave measurements did not appear to agree with those of previous experiments, known as WMAP and Planck, unless the simplest models of inflation were replaced by more complicated ones. On the first day and week of coverage, I became very disappointed with the many commentators who disregarded or underemphasized that the earlier measurements from instruments on WMAP and Planck, which had been reported and covered for years.

Sure enough, in the weeks that followed, other researchers pointed out that the signal that BICEP2 detected may have been attributable to the polarization of light caused by dust in our galaxy. The BICEP2 team certainly knew that dust could also polarize light in a similar way to gravitational waves, but they used a model, based on the data that was available from the Planck satellite, that, the other researchers pointed out, may have underestimated the amount of dust in the part of the sky they were studying.

The BICEP2 paper underwent peer review and was published in Physical Review Letters. As a result of the peer-review process, the researchers made revisions, including removing the model that contained the lower estimates of dust based on the earlier Planck data, and thereby reducing the certainty with which they could state that they accounted for signals from interstellar dust.

During the summer, the BICEP2 and Planck collaborations agreed to work together to analyze their data, to help determine if gravitational waves had really been detected.

This week, the Planck team issued a preprint, based on an analysis of much additional data, showing a comprehensive map of dust in the sky. According to their analysis, the signal in the part of sky that BICEP2 analyzed could be completely attributable to dust and not to gravitational waves.

But, the story is not over. For starters, keep in mind the new preprint, like all newly posted publications, still needs to undergo formal peer review.

And the latest data do not completely rule out the possibility that the BICEP2 group detected a gravitational wave signal. If the evidence holds up at all, it would likely be a weaker signal, after accounting for the dust. Or, the gravitational-wave signal may completely turn to dust.

It may be possible to detect primordial gravitational waves in a different, less dusty part of the sky, or with new measurements by BICEP2, Planck or the many other experiments that are looking for them.  Just as the first reported detections of exoplanets turned out to be false, perhaps this is a prelude to an actual detection of gravitational waves.

"You cannot ignore dust," he quotes from Planck scientist Charles Lawrence of NASA’s Jet Propulsion Laboratory in Pasadena, California.

The biggest lesson, to me, is that no one should rush to make announcements and pronouncements, whether big or small, even in the face of intense competition and the alluring prospects of launching a new field of study and winning a Nobel Prize. 

Scientists, and the rest of the public, should follow the time-tested scientific practice of subjecting claims to sufficient levels of scrutiny, and waiting for other groups to validate results, before making bold statements. At the very least, there have been major caveats and qualifiers in announcing new data with potentially huge implications.

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What is Enlightenment?

Thomas Razzeto, GrahamHancock.comMy most passionate plea is for you to wake up to your true self as pure awareness. We have all heard it said that you are not a human being having a spiritual experience, but instead, you are a spiritual being having a human experience. Yet you are not a being of any kind, spiritual or physical. You are pure awareness! And most importantly, your awareness is the One Awareness – the Divine Awareness – and as such, it is the only reality tha [...]

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Heaven Letters June-20-2013

Heavenletter #4591 All That Is, June 20, 2013
Gloria Wendroff
http://www.heavenletters.org/all-that-is.html

God said:
You’re not tired of My telling you how to live in the world, are you? You

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Heaven Letters 06-18-2013

Heavenletter #4589 Does Happenstance Exist?, June 18, 2013
Gloria Wendroff
http://www.heavenletters.org/does-happenstance-exist.html

God said:
What if everything that happens in your life is supposed to happen? Imagine for a moment:

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Galactic Federation of Light Sheldan Nidle May-28-2013

Sheldan’s update for May 28, 2013
http://www.paoweb.com/sn052813.htm

6 Etznab, 3 Pax, 9 Eb
Selamat Jarin! We come with many things to tell you! The dark cabal continues to search for

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Heaven Letters May-05-2013

Heavenletter #4545 Ultimately, What Matters?, May 5, 2013
Gloria Wendroff
http://www.heavenletters.org/ultimately-what-matters.html

God said:
What shall we talk about today? What have we been talking about? Does it matter? Does

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Galactic Federation of Light Archangel Raphael April-15-2013

Galactic Federation of Light El Morya April-09-2013

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