Tag: develop (page 2 of 10)

Is an Abundance of Arsenic Found in Rice Increasing Risk of Cancer?

May 21, 2015 / / 0 Comments

Brett Wilbanks, Staff WriterArsenic is a common element found in nature. It occurs naturally in a variety of sources, from soil and water, to foods that we eat on a regular basis. There are several forms of arsenic, and some, particularly certain inorganic forms, are more harmful than others.According to the International Agency for Research on Cancer, two compounds found in inorganic arsenic are known carcinogenic substances and are associated with a number of devastating health eff [...]

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NASA Challenges People to Come Up With Designs for Mars Habitat –

May 18, 2015 / / 0 Comments





Excerpt from perfscience.com

The space agency NASA has asked public to submit designs for a Mars habitat. NASA, along with the National Additive Manufacturing Innovation Institute, is holding a competition to design and build a 3-D printed habitat for deep space explorations like journey to Mars.  The multi-phase 3-D Printed Habitat Challenge has been specifically designed to advance the additive construction technology that is needed to develop sustainable housing solutions for earth and beyond.  As per experts, shelter is among most basic and crucial requirement for humans but carrying bulks of material to build up a habitat during a deep space mission would unnecessarily take the place in cargo that could be used for something important.  The first phase of the competition that was announced on Saturday will run through September 27. This phase calls on participants to develop state-of-the-art architectural concepts that take advantage of the unique capabilities 3-D printing offers.  The top 30 submissions will be considered and judged. Also winners will be awarded with prize money of $50,000 at the 2015 World Maker Faire in New York.  Sam Ortega, Centennial Challenges program manager, said, “This challenge definitely raises the bar from what we are currently capable of, and we are excited to see what the maker community does with it”... 
The space agency NASA has asked public to submit designs for a Mars habitat. NASA, along with the National Additive Manufacturing Innovation Institute, is holding a competition to design and build a 3-D printed habitat for deep space explorations like journey to Mars.
The multi-phase 3-D Printed Habitat Challenge has been specifically designed to advance the additive construction technology that is needed to develop sustainable housing solutions for earth and beyond.
As per experts, shelter is among most basic and crucial requirement for humans but carrying bulks of material to build up a habitat during a deep space mission would unnecessarily take the place in cargo that could be used for something important.
The first phase of the competition that was announced on Saturday will run through September 27. This phase calls on participants to develop state-of-the-art architectural concepts that take advantage of the unique capabilities 3-D printing offers.
The top 30 submissions will be considered and judged. Also winners will be awarded with prize money of $50,000 at the 2015 World Maker Faire in New York.
Sam Ortega, Centennial Challenges program manager, said, “This challenge definitely raises the bar from what we are currently capable of, and we are excited to see what the maker community does with it”.
Furthermore the second phase of the competition is divided into two levels i.e., the (Level 1) Structural Member Competition and the On-Site Habitat Competition (Level 2).
The Level 1 focuses on the fabrication technologies that are needed to manufacture structural components from a combination of indigenous materials and recyclables, or indigenous materials alone.
On the other hand, the Level 2 challenges competitors to construct full-scale habitats using indigenous materials or indigenous materials combined with recyclables.
- See more at: http://perfscience.com/content/2141815-nasa-challenges-people-come-designs-mars-habitat#sthash.vtPiW4bW.dpuf

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Report: No endangered animals in 200 zoos across the US!

May 17, 2015 / / 0 Comments




Excerpt from thenextdigit.com

On May 15, the 10th anniversary of Endangered Species Day has been kicked off across the United States, which sees a series of wildlife awareness events with the participation of over 200 zoos. These zoos across the country restricted access to a few of their endangered animals and birds to make visitors feel the non existence of such species.
Ohio’s Akron Zoo also participated in the awareness event, where it shrouded Sumatran tigers from visitors, with only limited access to visitors to capture a glimpse of the endangered tiger species. In Dallas Zoo, authorities kept the African penguins were kept away from visitors’ sight, while allowing those visitors who commit to eat sustainable seafood, switching off lights when not in use and such kind of conservation efforts.

Ohio’s Akron Zoo’s director of marketing and guest services David Barnhardt revealed that the zoo will be using this event to launch their own program SAFE (Saving Animals from Extinction) where the zoo will create awareness of saving endangered animals. SAFE is sponsored by the Association of Zoos and Aquariums. He also said,
“Through SAFE we will pull all of these resources we have available to us and develop action plans, raise awareness and engage the public to help these endangered species.”
Endangered Species Day is an opportunity for every humans to learn about the importance of animals, especially endangered species, and day to day actions they can take to protect these species, according to the Endangered Species Coalition. The Endangered Coalition not only sponsors events in the states, but also provides toolkits for zoos which interested in its own endangered species awareness programs such as SAFE.
Dallas Zoo has initiated a program in February 2015, named as the Wild Earth Academy, which educates people about endangered species. Ben Jones, Wild Earth Academy’s Senior Director and Dean, said in a statement:
“There’s a balance in nature and it’s very evident that that balance is becoming imbalanced, it’s shifting. We have to do our part to use the resources that we have, but not use them up.”
The Coalition also produces the yearly report “Vanishing: Ten American Species Our Children May Never See” – listing the top 10 most endangered species during the time of reporting. 2014’s ‘Vanishing’ report listed endangered animals like the Monarch butterfly, Mountain yellow-legged frog (extinct from southern Sierra Nevada), North Pacific right whale, great white shark (California/Mexico), little brown bat (extinct due to white-nose syndrome, an illness caused by a deadly fungus from Europe), whitebark pine, rusty patched bumblebee, greater sage-grouse, polar bear and snake river sockeye salmon.

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How to make oxygen on Mars: Nasa plans to use oxygen cocktail to support human colony

May 16, 2015 / / 0 Comments

An Indiana firm is developing a method to make oxygen on Mars for Nasa. Bacteria and algae will use Martian soil as fuel to pump out oxygen. Mars could be scattered with biodomes containing the organisms. And future astronauts could use this oxygen to survive on the surface (artist's illustration shown)
An Indiana firm is developing a method to make oxygen on Mars for Nasa. Bacteria and algae will use Martian soil as fuel to pump out oxygen. Mars could be scattered with biodomes containing the organisms. And future astronauts could use this oxygen to survive on the surface (artist's illustration shown)

Excerpt from dailymail.co.uk
  • An Indiana firm is developing a method to make oxygen on Mars for Nasa
  • Bacteria and algae will use Martian soil as fuel to pump out oxygen
  • Mars could be scattered with biodomes containing the organisms
  • And future astronauts could use this oxygen to survive on the surface

If humans land on Mars in the 2030s as planned, one thing that will be essential to their survival will be self-sufficiency, as they won’t be able to take too much cargo with them.

With this in mind Nasa is testing whether oxygen can be created from Martian soil, without having to carry it all the way from Earth.

The innovative method would see bacteria or algae use the soil as fuel, pumping out usable oxygen in the process for astronauts on the surface.

Nasa has been working with Techshot Inc of Greenville, Indiana to develop this method in a so-called ‘Mars room’, which mimics the conditions on the red planet.
It is able to simulate the atmospheric pressure on the planet, in addition to the day-night temperature changes and the solar radiation that hits the surface.

In experiments, certain organisms were capable of producing oxygen from Martian soil - known as regolith - and they also removed nitrogen from it. 

‘This is a possible way to support a human mission to Mars, producing oxygen without having to send heavy gas canisters,’ said Eugene Boland, chief scientist at Techshot.

‘Let’s send microbes and let them do the heavy-lifting for us.’
The research is part of the Nasa Innovative Advanced Concepts (NIAC) Programme.

It’s envisioned that biodomes could be scattered across the surface to produce the oxygen needed for humans to survive.

The oxygen produced could also be stored for later use.

But while experiments on Earth are all well and good, the scientists want to test their method actually on Mars in the near future.

The 'Mars room', shown, is able to simulate the atmospheric pressure on the planet, in addition to the day-night temperature changes and the solar radiation that hits the surface. In experiments certain organisms were capable of producing oxygen from Martian soil inside the laboratory
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The 'Mars room', shown, is able to simulate the atmospheric pressure on the planet, in addition to the day-night temperature changes and the solar radiation that hits the surface. In experiments certain organisms were capable of producing oxygen from Martian soil inside the laboratory

When humans land on Mars in the future (artist's illustration of the landing shown), they will need to be as self-sufficient as possible
When humans land on Mars in the future (artist's illustration of the landing shown left), they will need to be as self-sufficient as possible.




To do so, an upcoming rover - such as the 2020 Mars rover - could carry small container-like devices with Earth organisms inside.

The containers would be buried a few inches underground in certain locations, to see how successful they are at producing oxygen.

Sensors inside the container would detect how much oxygen was made, and report the findings back to a satellite in Mars orbit.

The scientists note that the container would be sealed tightly, to prevent the organisms being exposed to - and possibly contaminating - the Martian surface.

But if proven successful, future explorers on Mars may use multiple biodomes like this to produce the oxygen they need to survive.


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CRISPR-Cas9 modifies your DNA, under legal fire ~ Video

May 16, 2015 / / 0 Comments




Excerpt from slashgear.com

A revolutionary method of editing the human genome has this week become the subject of a patent war. Back in April of 2014, patents were awarded by the USPTO (United States Patent and Trademark Office) to the Broad Institutes’ Dr. Feng Zhang, MIT, and Harvard to develop the technology behind "CRISPR-Cas9". 
This April, the UC Board of Regents’ legal team spoke with the USPTO about reconsidering their action, suggesting they award the patent to the inventor of the original method, UC Berkeley’s Jennifer Doudna. One way or another, this radical DNA modifier must be made. 

We need X-Men, after all.


The following video will explain what this genome-editing piece of technological breakthrough is all about. CRISPR-Cas9 is what it's called, and getting in to your body to make changes on a DNA level is what it's going for.

CRISPR-Cas9 works as a tiny scissors.

Utilizing the natural bacterial-level protective system used by your body to fight infections, CRISPR-Cas9 replicates the sequences of target DNA strands and latches on.

It's the connector that CRISPR-Cas9 makes real, and really programmable.

Your body provides the Cas9.* The Cas9 is the nuclease enzyme that cuts DNA strands.

*Correction - BACTERIA have Cas9, not our human selves. As helpful commenter "John" put so eloquently, "So far it has only been found in bacterial cells, and that's one of the things that makes it so amazing--a relatively simple molecular system that replicates many of the functions of our elaborate adaptive immune response, all in a single prokaryotic cell!"

Screen Shot 2015-05-15 at 10.11.42 AM
ABOVE: Image comes via Nature; Addgene, By Jonathan Corum, via NYT.

When a DNA sequence is cut, it may attempt to re-form. In doing so, it can create mutations.

But that's a discussion for another day.

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Genetically altered twin monkeys have been made using the CRISPR-Cas9 method. As you'll see in DOI: http://dx.doi.org/10.1016/j.cell.2014.01.027 in Cell Symposia "Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos", these monkeys are living large on gene-altered action.

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Today what's important is that two groups are fighting for the patents involved in CRISPR-Cas9.

A paper published online June 28 2012 by Science authored by Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A. Doudna, and Emmanuelle Charpentier describes the method: "A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity."

You can find this paper under code DOI: 10.1126/science.1225829.

Dr. Zhang suggests he demonstrated the CRISPR genome editing method before the 2012 paper was published by Dr. Doudna and Dr. Charpentier and crew. Dr. Doudna and Dr. Charpentier and crew suggest say Dr. Zhang's notebook (used as proof for patents) does not prove genome editing before the 2012 paper was published.

Can't we all just get along? Think of the monkeys!

Click to zoom

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The Class-Domination Theory of Power

May 9, 2015 / / 0 Comments

by G. William DomhoffNOTE: WhoRulesAmerica.net is largely based on my book,Who Rules America?, first published in 1967 and now in its7th edition. This on-line document is presented as a summary of some of the main ideas in that book.Who has predominant power in the United States? The short answer, from 1776 to the present, is: Those who have the money -- or more specifically, who own income-producing land and businesses -- have the power. George Washington was one of the biggest landowner [...]

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Desperately Seeking ET: Fermi’s Paradox Turns 65 ~ Part 2

May 5, 2015 / / 0 Comments

Excerpt from huffingtonpost.comIntroductionWhy is it so hard to find ET? After 50 years of searching, the SETI project has so far found nothing. In the latest development, on April 14, 2015 Penn State researchers announced that after searching through...

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Nuclear Experimentation Year 70 – Playing With Madness

May 5, 2015 / / 0 Comments

Ethan Indigo Smith, ContributorThe recent “news” on the nuclear situation in Iran brings to light the madhouse of cards on which the postmodern world is built. Or rather, it would bring the madness to light if the major media outlets of the world were not bought up and sold out to the military industrial complex, and therefore completely misinformed on the actions and dangers of the nuclear experimentation industry.The story is not just about [...]

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Lab for genetic modification of human embryos just $2,000 away – report

May 1, 2015 / / 0 Comments


Reuters / Christian Charisius



Reuters

With the right expertise in molecular biology, one could start a basic laboratory to modify human embryos using a genome-editing computer technique all for a couple thousand dollars, according to a new report.

Genetic modification has received heightened scrutiny recently following last week’s announcement that Chinese researchers had, for the first time, successfully edited human embryos’ genomes. 
The team at Sun Yat-Sen University in Guangzhou, China, used CRISPR (clustered regularly interspaced palindromic repeats), a technique that relies on “cellular machinery” used by bacteria in defense against viruses. 

This machinery is copied and altered to create specific gene-editing complexes, which include the wonder enzyme Cas9. The enzyme works its way into the DNA and can be used to alter the molecule from the inside. The combination is attached to an RNA guide that takes the gene-editing complex to its target, telling Cas9 where to operate. 

Use of the CRISPR technique is not necessarily relegated to the likes of cash-flush university research operations, according to a report by Business Insider. 


Geneticist George Church, who runs a top CRISPR research program at the Harvard Medical School, said the technique could be employed with expert knowledge and about half of the money needed to pay for an average annual federal healthcare plan in 2014 -- not to mention access to human embryos. 

"You could conceivably set up a CRISPR lab for $2,000,” he said, according to Business Insider. 

Other top researchers have echoed this sentiment. 

"Any scientist with molecular biology skills and knowledge of how to work with [embryos] is going to be able to do this,” Jennifer Doudna, a biologist at the University of California, Berkeley, recently told MIT Tech Review, which reported that Doudna co-discovered how to edit genetic code using CRISPR in 2012. 

Last week, the Sun Yat-Sen University research team said it attempted to cure a gene defect that causes beta-thalassemia (a genetic blood disorder that could lead to severe anemia, poor growth, skeletal abnormalities and even death) by editing the germ line. For that purpose they used a gene-editing technique based on injecting non-viable embryos with a complex, which consists of a protective DNA element obtained from bacteria and a specific protein. 

"I suspect this week will go down as a pivotal moment in the history of medicine," wrote science journalist Carl Zimmer for National Geographic.


Response to the new research has been mixed. Some experts say the gene editing could help defeat genetic diseases even before birth. Others expressed concern. 

“At present, the potential safety and efficacy issues arising from the use of this technology must be thoroughly investigated and understood before any attempts at human engineering are sanctioned, if ever, for clinical testing,” a group of scientists, including some who had worked to develop CRISPR, warned in Science magazine. 

Meanwhile, the director of the US National Institutes for Health (NIH) said the agency would not fund such editing of human embryo genes. 

“Research using genomic editing technologies can and are being funded by NIH,” Francis Collins said Wednesday. “However, NIH will not fund any use of gene-editing technologies in human embryos. The concept of altering the human germline in embryos for clinical purposes ... has been viewed almost universally as a line that should not be crossed.”

Although the discovery of CRISPR sequences dates back to 1987 – when it was first used to cure bacteria of viruses – its successes in higher animals and humans were only achieved in 2012-13, when scientists achieved a revolution by combining the resulting treatment system with Cas9 for the first time. 


On April 17, the MIT’s Broad Institute announced that has been awarded the first-ever patent for working with the Crisp-Cas9 system. 

The institute’s director, Eric Lander, sees the combination as “an extraordinary, powerful tool. The ability to edit a genome makes it possible to discover the biological mechanisms underlying human biology.”

The system’s advantage over other methods is in that it can also target several genes at the same time, working its way through tens of thousands of so-called 'guide' RNA sequences that lead them to the weapon to its DNA targets. 

Meanwhile, last month in the UK, a healthy baby was born from an embryo screened for genetic diseases, using karyomapping, a breakthrough testing method that allows doctors to identify about 60 debilitating hereditary disorders.

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17 Surprising Reasons You’re Stressed Out

April 13, 2015 / / 0 Comments





Excerpt from huffingtonpost.com
By Amanda MacMillan


You're probably all too aware of the major sources of stress in your life -- money, your terrible commute, the construction workers who start jackhammering at 5 a.m. But stress and anxiety don't have to just come from obvious or even negative sources. "There are plenty of chronic strains and low-grade challenges that don't necessarily overwhelm you in the moment, but almost take more of a toll in the long run," says Scott Schieman, Ph.D., professor of sociology at the University of Toronto. These are some of unexpected reasons why you might feel anxious or agitated. By recognizing them for what they are, says Schieman, you can better prepare to cope.

1. Your Significant Other
Even if you have a blissfully happy relationship with your live-in partner or spouse, you're both bound to do things that get on each other's nerves. "Early in the relationship, it's usually about space and habits -- like whether you squeeze the toothpaste from the middle or the bottom of the tube," says Ken Yeager, Ph.D., associate professor of psychiatry at the Ohio State University Wexner Medical Center. "Later on, you might clash over parenting style or financial issues, and finding a unified front to face these issues together." So what's the key to surviving and thriving in your life together? Finding balance, says Yeager: spending the right amount of time together (not too much and not too little), making compromises, keeping communication open and honest, and remembering to acknowledge what you love about each other on a daily basis.

2. Everyday Annoyances
We're told not to sweat the small stuff, but sometimes it's the little things that have the biggest impact on our mood: the never-ending phone calls with your insurance company, the rude cashier at the grocery store, the 20 minutes you lose looking for a parking space. "We let these things bother us because they trigger unconscious fears," says Yeager -- fears of being seen as irresponsible, of being bullied or embarrassed, or of being late all the time, for example. "Sometimes you need to take a step back and realize that you're doing the best you can given the circumstances." 

3. Other People's Stress
Stress is contagious, according to a 2014 German study: In a series of experiments, most participants who simply observed others completing a stressful task experienced an increase themselves in production of the stress hormone cortisol -- a phenomenon known as empathic stress. You can also experience stress when someone you know is affected by a traumatic event, like a car crash or a chronic illness. "You start to worry, 'Oh my gosh, could that happen to me?'," says Yeager. "We tend not to think about these things until they hit close to home."

4. Social Media social media
It may seem like Facebook is the only way you keep up with the friends you don't see regularly -- which, during particularly busy times, can be just about all of them. The social network also has a downside, according to a 2015 study from the Pew Research Center: It can make you aware of stressful situations in your friends' lives, which in turn can add more stress to your life. The Pew report didn't find that social media users, overall, had higher levels of stress, but previous studies have suggested that frequent social-media use can be associated with negative body image and prolonged breakup pain.

5. Distraction
A distraction can be a good thing then when it takes your mind off of a stressful situation or difficult decision, like when you take a break from work to meet a friend for lunch. But it works the other way, as well: When you're so busy thinking about something else that you can't enjoy what's going on around you, that kind of distraction can be a recipe for stress. Practicing mindfulness gives you brain the refresh it needs, says Richard Lenox, director of the Student Counseling Center at Texas Tech University. Paying full attention to your surroundings when you're walking and driving can help, he adds. "Stress and anxiety tend to melt away when our mind is focused on the present." 

6. Your Childhood
Traumatic events that happened when you were a kid can continue to affect your stress levels and overall health into adulthood. A 2014 University of Wisconsin-Madison study found that these childhood experiences may actually change parts of the brain responsible for processing stress and emotion. The way you were raised can also have a lasting impact on your everyday angst, suggests a 2014 Johns Hopkins University study. Researchers found that children of parents with social anxiety disorders are more likely to develop "trickle-down anxiety" -- not simply because of their genes, but because of their parents' behaviors toward them such as a lack of warmth and emotion, or high levels of criticism and doubt.

7. Tea And Chocolate
You probably know to take it easy on the coffee when you're already feeling on edge. "Caffeine is always going to make stress worse," says Yeager. But you may not think as much about drinking several cups of tea at once, or chowing down on a bar of dark chocolate -- both of which can contain nearly as much caffeine as a cup of joe. "Chocolate is a huge caffeine source," says Yeager. "I know people who don't drink coffee but they'll eat six little candy bars in a two-hour period because they want the same kind of jolt." Too much caffeine, in any form, can cause problems with sleep, digestion, and irritability. 

8. Your Expectations woman trail running
When things don't go the way you've planned, do you tend to get upset and act defensively, or do you roll with the punches and set off on a new plan? If it's the former, you could be contributing to a mindset of pessimism and victimization that will slowly wear you down, even when things may not be as bad as they seem. "Your level of serenity is inversely proportionate to your expectations," says Yeager. That doesn't mean you shouldn't set ambitious goals for yourself or settle for less than what you want, of course, but being realistic about what's truly possible is important, as well.

9. Your Reaction To Stress
If you tend to deal with stressful situations by working long hours, skipping your workouts, and bingeing on junk food, we've got some bad news: You're only making it worse. "We know that physical activity and healthy foods will help your body better deal with stress, and yet we often avoid them when we need them the most," says Yeager. "People really need to think about this downward spiral we get into and work harder to counteract it."

10. Multitasking
Think you're being super efficient by tackling four tasks at once? Chances are you're not -- and it's only decreasing your productivity while increasing your stress. A 2012 University of Irvine study, for example, found that people who responded to emails all day long while also trying to get their work done experienced more heart-rate variability (an indicator of mental stress) than those who waited to respond to all of their emails at one time. Focusing on one task at a time can ensure that you're doing that job to the best of your abilities and getting the most out of it, so you won't have to worry about or go back and fix it later, says Schieman. And don't worry: You'll have enough time to do it all. In fact, you may discover you have more time than you thought.

11. Your Favorite Sport
Watching a tight game of college hoops can stress you out -- even if your alma mater wins. "The body doesn't distinguish between 'bad' stress from life or work and 'good' stress caused by game-day excitement," says Jody Gilchrist, a nurse practitioner at the University of Alabama at Birmingham’s Heart and Vascular Clinic. Watching sports can even trigger the body's sympathetic nervous system, releasing adrenaline and reducing blood flow to the heart. Those temporary consequences aren't usually anything to be concerned about, but over time, chronic stress can lead to high blood pressure and increased disease risk. And, of course, it doesn't help if you're adding alcohol and binge-eating to a situation that's already stressful on your body. You may not be able to control the outcome of the game, says Gilchrist, but you can limit its effects on your own body. 

12. Digital Devices laptop in bed
Whether you're using it for work or play, technology may play a large role in your mental health, says Yeager. Using computers or e-readers too close to bedtime could lead to sleep problems, he says, and spending too much time virtually socializing can make real-life interactions seem extra stressful. (Plus, texting doesn't trigger the same feel-good hormones as face-to-face talk does.) Then there's the dreaded "work creep," says Schieman, when smartphones allow employees to be tethered to their jobs, even during off-hours. "People say they're only going to check email for an hour while they're on vacation, but the problem with email is that they're filled with responsibilities, new tasks, and dilemmas that are going to be hard to compartmentalize and put out of your head once that hour is up."

13. Your (Good) Health
While it may not be as stressful as having a chronic illness or getting bad news at the doctor's office, even people in the best shape of their lives worry about their bodies, their diets, and their fitness levels. In fact, people who take healthy living to an extreme may experience some rather unhealthy side effects. People who follow low-carb diets, for example, are more likely to report being sad or stressed out, while those on any kind of restrictive meal plan may feel more tired than usual. And it's not unheard of for someone to become obsessed with healthy eating (known as orthorexia) or working out (gymorexia). Like any form of perfectionism, these problems can be stressful at best, and extremely dangerous at worst.

14. Housework
Does folding laundry help you feel calm, or does it make your blood boil? If you're in a living situation where you feel you're responsible for an unfair share of work, even chores you once enjoyed may start to feel like torture. "Dividing up housework and parenting responsibilities can be tricky, especially if both partners work outside the home," says Schieman. "And whether you define that division of labor as equal or unequal can really change your attitude toward it."

15. Uncertainty
Stress can be defined as any perceived or actual threat, says Yeager, so any type of doubt that's looming over you can contribute to your anxiety levels on a daily basis. "When you know something could change at any minute, you always have your guard up and it's hard to just relax and enjoy anything." Financial uncertainty may be the most obvious stressor -- not being sure if you'll keep your job during a round of layoffs, or not knowing how you'll pay your credit card bill. Insecurities in other areas of life, like your relationship or your housing status, can eat away at you too.

16. Your Pet bulldog puppy
No matter how much you love your furry friends, there's no question that they add extra responsibility to your already full plate. Even healthy animals need to be fed, exercised, cleaned up after, and given plenty of attention on a regular basis -- and unhealthy ones can be a whole other story. "Pets can be the most positive source of unconditional love, but at the same time they require an extreme amount of energy," says Yeager. People also tend to underestimate the stress they'll experience when they lose a pet. "I've had people in my office tell me they cried more when their dog died than when their parent died. It's a very emotional connection."

17. Your Education
Having a college degree boosts your odds of landing a well-paying job, so although you're less likely to suffer from money-related anxiety, your education can bring on other types of stress, according to a 2014 study by Schieman and his University of Toronto colleagues. His research found that highly educated people were more likely to be stressed out thanks to job pressures, being overworked, and conflicts between work and family. "Higher levels of authority come with a lot more interpersonal baggage, such as supervising people or deciding whether they get promotions," says Schieman. "With that type of responsibility, you start to take things like incompetency and people not doing their jobs more personally, and it bothers you more."

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Is In-Flight Refueling Coming to Commercial Airlines?

April 12, 2015 / / 0 Comments




Excerpt from space.com

 This article was originally published on The Conversation. The publication contributed this article to Space.com's Expert Voices: Op-Ed & Insights.

There’s real pressure on the aviation industry to introduce faster, cheaper and greener aircraft, while maintaining the high safety standards demanded of airlines worldwide.

Airlines carry more than three billion passengers each year, which presents an enormous challenge not only for aircraft manufacturers but for the civil aviation infrastructure that makes this extraordinary annual mass-migration possible. Many international airports are close to or already at capacity. The International Air Transport Association (IATA) has estimated that, without intervention, many global airports – including major hubs such as London Heathrow, Amsterdam Schiphol, Beijing and Dubai – will have run out of runway or terminal capacity by 2020. 


The obvious approach to tackling this problem is to extend and enlarge airport runways and terminals – such as the long-proposed third runway at London Heathrow. However there may be other less conventional alternatives, such as introducing in-flight refuelling for civil aircraft on key long-haul routes. Our project, Research on a Cruiser-Enabled Air Transport Environment (Recreate), began in 2011 to evaluate whether this was something that could prove a viable, and far cheaper, solution.

If in-flight refuelling seems implausible, it’s worth remembering that it was first trialed in the 1920s, and the military has continued to develop the technology ever since. The appeal is partly to reduce the aircraft’s weight on take-off, allowing it to carry additional payload, and partly to extend its flight range. Notably, during the Falklands War in 1982 RAF Vulcan bombers used in-flight refuelling to stage what was at the time the longest bombing mission ever, flying 8,000 miles non-stop from Ascension Island in the South Atlantic to the Falklands and back.

Reducing take-off weight could offer many benefits for civilian aircraft too. Without the need to carry so much fuel the aircraft can be smaller, which means less noise on take-off and landing and shorter runways. This opens up the network of smaller regional airports as new potential sites for long-haul routes, relieving pressure on the major hubs that are straining at the seams.

There are environmental benefits too, as a smaller, lighter aircraft requires less fuel to reach its destination. Our initial estimates from air traffic simulations demonstrate that it’s possible to reduce fuel burn by up to 11% over today’s technology by simply replacing existing global long-haul flight routes with specifically designed 250-seater aircraft with a range of 6,000nm after one refuelling – roughly the distance from London to Hong Kong. This saving could potentially grow to 23% with further efficiencies, all while carrying the same number of passengers the same distance as is possible with the current aircraft fleet, and despite the additional fuel burn of the tanker aircraft.

Tornado fighter jets in-flight refuel
Imagine if these Tornado fighter jets were 250-seater passenger aircraft and you’ve got the idea.

However, this is not the whole picture – in-flight refuelling will require the aerial equivalent of petrol stations in order to deliver keep passenger aircraft in the sky. With so much traffic it simply wouldn’t be possible to refuel any aircraft any time, anywhere it was needed. The location of these refuelling zones, coupled with the flight distance between the origin and destination airports can greatly affect the potential benefits achievable, possibly pulling flights away from their shortest route, and even making refuelling on some routes impossible – if for example the deviation to the nearest refuelling zone meant burning as much fuel as would have been saved.

Safety and automation

As with all new concepts – particularly those that involve bringing one aircraft packed with people and another full of fuel into close proximity during flight – it’s quite right to ask whether this is safe. To try and answer this question, the Dutch National Aerospace Laboratory and German Aerospace Centre used their flight simulators to test the automated in-flight refuelling flight control system developed as part of the Recreate project.

One simulator replicated the manoeuvre from the point of view of the tanker equipped with an in-flight refuelling boom, the other simulated the aircraft being refuelled mid-flight. Critical test situations such as engine failure, high air turbulence and gusts of wind were simulated with real flight crews to assess the potential danger to the operation. The results were encouraging, demonstrating that the manoeuvre doesn’t place an excessive workload on the pilots, and that the concept is viable from a human as well as a technical perspective.

So far we’ve demonstrated the potential aerial refuelling holds for civilian aviation, but putting it into practice would still pose challenges. Refuelling hubs would need to be established worldwide, shared between airlines. There would need to be fundamental changes to airline pilot training, alongside a wider public acceptance of this departure from traditional flight operations.

However, it does demonstrate that, in addition to all the high-tech work going into designing new aircraft, new materials, new engines and new fuels, the technology we already have offers solutions to the long-term problems of ferrying billions of passengers by air around the world.

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Biologists fear DNA editing procedure can alter human DNA

March 20, 2015 / / 0 Comments




Excerpt from themarketbusiness.com

A group of biologists was alarmed with the use a new genome-editing technique to modify human DNA in a way that it can become hereditary.
The biologists worry that the new technique is so effective and easy to use that some physicians may push ahead with it before its safety can be weigh up. They also want the public to understand the ethical issues surrounding the technique, which could be used to cure genetic diseases, but also to enhance qualities like beauty or intelligence. The latter is a path that many ethicists believe should never be taken.

“You could exert control over human heredity with this technique, and that is why we are raising the issue,” said David Baltimore, a former president of the California Institute of Technology and a member of the group whose paper on the topic was published in the journal Science.

Ethicists have been concerned for decades about the dangers of altering the human germ line — meaning to make changes to human sperm, eggs or embryos that will last through the life of the individual and be passed on to future generations. Until now, these worries have been theoretical. But a technique invented in 2012 makes it possible to edit the genome precisely and with much greater ease. The technique has already been used to edit the genomes of mice, rats and monkeys, and few doubt that it would work the same way in people.

The new genome-editing technique holds the power to repair or enhance any human gene. “It raises the most fundamental of issues about how we are going to view our humanity in the future and whether we are going to take the dramatic step of modifying our own germline and in a sense take control of our genetic destiny, which raises enormous peril for humanity,” said George Daley, a stem cell expert at Boston Children’s Hospital and a member of the group.

The biologists writing in Science support continuing laboratory research with the technique, and few if any scientists believe it is ready for clinical use. Any such use is tightly regulated in the United States and Europe. American scientists, for instance, would have to present a plan to treat genetic diseases in the human germline to the Food and Drug Administration.

The paper’s authors, however, are concerned about countries that have less regulation in science. They urge that “scientists should avoid even attempting, in lax jurisdictions, germ line genome modification for clinical application in humans” until the full implications “are discussed among scientific and governmental organizations.”

Though such a moratorium would not be legally enforceable and might seem unlikely to exert global sway, there is a precedent. In 1975, scientists worldwide were asked to refrain from using a method for manipulating genes, the recombinant DNA technique, until rules had been established.

“We asked at that time that nobody do certain experiments, and in fact nobody did, to my knowledge,” said Baltimore, who was a member of the 1975 group. “So there is a moral authority you can assert from the U.S., and that is what we hope to do.”

Recombinant DNA was the first in a series of ever-improving steps for manipulating genetic material. The chief problem has always been one of accuracy, of editing the DNA at precisely the intended site, since any off-target change could be lethal. Two recent methods, known as zinc fingers and TAL effectors, came close to the goal of accurate genome editing, but both are hard to use. The new genome-editing approach was invented by Jennifer Doudna of the University of California, Berkeley, and Emmanuelle Charpentier of Umea University in Sweden.

Their method, known by the acronym Crispr-Cas9, co-opts the natural immune system with which bacteria remember the DNA of the viruses that attack them so they are ready the next time those same invaders appear. Researchers can simply prime the defense system with a guide sequence of their choice and it will then destroy the matching DNA sequence in any genome presented to it. Doudna is the lead author of the Science article calling for control of the technique and organized the meeting at which the statement was developed.

Though highly efficient, the technique occasionally cuts the genome at unintended sites. The issue of how much mistargeting could be tolerated in a clinical setting is one that Doudna’s group wants to see thoroughly explored before any human genome is edited.

Scientists also say that replacing a defective gene with a normal one may seem entirely harmless but perhaps would not be.
“We worry about people making changes without the knowledge of what those changes mean in terms of the overall genome,” Baltimore said. “I personally think we are just not smart enough — and won’t be for a very long time — to feel comfortable about the consequences of changing heredity, even in a single individual.”
Many ethicists have accepted the idea of gene therapy, changes that die with the patient, but draw a clear line at altering the germline, since these will extend to future generations. The British Parliament in February approved the transfer of mitochondria, small DNA-containing organelles, to human eggs whose own mitochondria are defective. But that technique is less far-reaching because no genes are edited.

There are two broad schools of thought on modifying the human germline, said R. Alta Charo, a bioethicist at the University of Wisconsin and a member of the Doudna group. One is pragmatic and seeks to balance benefit and risk. The other “sets up inherent limits on how much humankind should alter nature,” she said. 
Some Christian doctrines oppose the idea of playing God, whereas in Judaism and Islam there is the notion “that humankind is supposed to improve the world.” She described herself as more of a pragmatist, saying, “I would try to regulate such things rather than shut a new technology down at its beginning.”

Other scientists agree with the Doudna group’s message.
“It is very clear that people will try to do gene editing in humans,” said Rudolf Jaenisch, a stem cell biologist at the Whitehead Institute in Cambridge, Massachusetts, who was not a member of the Doudna group. “This paper calls for a moratorium on any clinical application, which I believe is the right thing to do.”
Writing in Nature last week, Edward Lanphier and other scientists involved in developing the rival zinc finger technique for genome editing also called for a moratorium on human germline modification, saying that use of current technologies would be “dangerous and ethically unacceptable.”

The International Society for Stem Cell Research said Thursday that it supported the proposed moratorium.

The Doudna group calls for public discussion but is also working to develop some more formal process, such as an international meeting convened by the National Academy of Sciences, to establish guidelines for human use of the genome-editing technique.

“We need some principled agreement that we want to enhance humans in this way or we don’t,” Jaenisch said. “You have to have this discussion because people are gearing up to do this.”

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Billionaire teams up with NASA to mine the moon

March 10, 2015 / / 0 Comments




Excerpt from cnbc.com
By Susan Caminiti



Moon Express, a Mountain View, California-based company that's aiming to send the first commercial robotic spacecraft to the moon next year, just took another step closer toward that lofty goal. 

Earlier this year, it became the first company to successfully test a prototype of a lunar lander at the Kennedy Space Center in Florida. The success of this test—and a series of others that will take place later this year—paves the way for Moon Express to send its lander to the moon in 2016, said company co-founder and chairman Naveen Jain.

Moon Express conducted its tests with the support of NASA engineers, who are sharing with the company their deep well of lunar know-how. The NASA lunar initiative—known as Catalyst—is designed to spur new commercial U.S. capabilities to reach the moon and tap into its considerable resources.In addition to Moon Express, NASA is also working with Astrobotic Technologies of Pittsburgh, Pennsylvania, and Masten Space Systems of Mojave, California, to develop commercial robotic spacecrafts. 

Jain said Moon Express also recently signed an agreement to take over Space Launch Complex 36 at Cape Canaveral. The historic launchpad will be used for Moon Express's lander development and flight-test operations. Before it was decommissioned, the launchpad was home to NASA's Atlas-Centaur rocket program and its Surveyor moon landers.

"Clearly, NASA has an amazing amount of expertise when it comes to getting to the moon, and it wants to pass that knowledge on to a company like ours that has the best chance of being successful," said Jain, a serial entrepreneur who also founded Internet companies Infospace and Intelius. He believes that the moon holds precious metals and rare minerals that can be brought back to help address Earth's energy, health and resource challenges. 

Among the moon's vast riches: gold, cobalt, iron, palladium, platinum, tungsten and Helium-3, a gas that can be used in future fusion reactors to provide nuclear power without radioactive waste. "We went to the moon 50 years ago, yet today we have more computing power with our iPhones than the computers that sent men into space," Jain said. "That type of exponential technological growth is allowing things to happen that was never possible before."

An eye on the Google prize

Source: MoonExpress

Helping to drive this newfound interest in privately funded space exploration is the Google Lunar X Prize. It's a competition organized by the X Prize Foundation and sponsored by Google that will award $30 million to the first company that lands a commercial spacecraft on the moon, travels 500 meters across its surface and sends high-definition images and video back to Earth—all before the end of 2016.

Moon Express is already at the front of the pack. In January it was awarded a $1 million milestone prize from Google for being the only company in the competition so far to test a prototype of its lander. "Winning the X prize would be a great thing," said Jain. "But building a great company is the ultimate goal with us." When it comes to space exploration, he added, "it's clear that the baton has been passed from the government to the private sector."

Testing in stages

Jain said Moon Express has been putting its lunar lander through a series of tests at the space center. The successful outing earlier this year involved tethering the vehicle—which is the size of a coffee table—to a crane in order to safely test its control systems. "The reason we tethered it to the crane is because the last thing we wanted was the aircraft to go completely haywire and hurt someone," he said. 

At the end of March, the company will conduct a completely free flight test with no tethering. The lander will take off from the pad, go up and sideways, then land back at the launchpad. "This is to test that the vehicle knows where to go and how to get back to the launchpad safely," Jain explained.


Once all these tests are successfully completed, Jain said the lander—called MX-1—will be ready to travel to the moon. The most likely scenario is that it will be attached to a satellite that will take the lander into a low orbit over the Earth. From there the MX-1 will fire its own rocket, powered by hydrogen peroxide, and launch from that orbit to complete its travel to the moon's surface. 

The lander's first mission is a one-way trip, meaning that it's not designed to travel back to the Earth, said Jain. "The purpose is to show that for the first time, a company has developed the technology to land softly on the moon," he said. "Landing on the moon is not the hard part. Landing softly is the hard part." 

That's because even though the gravity of the moon is one-sixth that of the Earth's, the lander will still be traveling down to the surface of the moon "like a bullet," Jain explained. Without the right calculations to indicate when its rockets have to fire in order to slow it down, the lander would hit the surface of the moon and break into millions of pieces. "Unlike here on Earth, there's no GPS on the moon to tell us this, so we have to do all these calculations first," he said. 

Looking ahead 15 or 20 years, Jain said he envisions a day when the moon is used as a sort of way station enabling easier travel for exploration to other planets. In the meantime, he said the lander's second and third missions could likely involve bringing precious metals, minerals and even moon rocks back to Earth. "Today, people look at diamonds as this rare thing on Earth," Jain said.
He added, "Imagine telling someone you love her by giving her the moon."

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