Robert Oliva, Collective-EvolutionThere is a cancer eating at the core of medical research.You’ve most likely heard of medical reports touting the effectiveness of a diet plan, a new drug, a supplement, or medical procedure. You may have even decided on a course of action based on these findings, only to find out later that they have been refuted by new studies.Strikingly, the odds are that the studies that influenced your decision, and possibly the decision of your doctor, wer [...]
Excerpt from huffingtonpost.comWe are at last beginning to show that there is an intimate and dynamic relationship between what is going on with our feelings and thoughts and what happens in the body. A Time magazine special showed that happiness, h...
The couple has a small menagerie of their own already -- Tracey told USA Today that their brood currently includes two each of kids, pigs, hamsters, guinea pigs and fish, plus four dogs, three rabbits and a parrot.
"All rescues," she said. "Except for the children."
Farm Sanctuary spokesperson Meredith Turner couldn't give The Huffington Post many details about the Stewarts' reported farm animal haven, but she did say, “We are ecstatic that there are people in the world like Jon and Tracey who care about the plight of factory farmed animals, and we encourage others to join them in support of Farm Sanctuary’s efforts to rescue, provide shelter and advocacy for these beautiful individuals.”
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Marco Torres, Prevent DiseaseWith a progressively educated population becoming more aware of the inherent dangers of the conventional food supply, urban farming has become hugely popular. However, more people are also becoming aware of contaminated soil and how heavy metals pose potential risks to their food crops. As backyard gardening continues to explode in popularity, we must ask how contaminated is our soil?Many municipalities in many countries are embracing urban agri [...]
Excerpt from huffingtonpost.com Sometimes, it's the most fantastical, fictional characters that do the best job of teaching us about reality.New York Times bestselling author T.A. Barron spent decades creating the magical image of Merlin the wiza...
Excerpt from huffingtonpost.comKarl Pillemer, a Ph.D. gerontologist at Cornell University, has spent the last several years interviewing hundreds of older Americans to systematically collect their practical wisdom.His first book, 30 Lessons for Livin...
The idea began percolating, said Dan Price, the founder of Gravity Payments, after he read an article on happiness. It showed that, for people who earn less than about $70,000, extra money makes a big difference in their lives.
His idea bubbled into reality on Monday afternoon, when Mr. Price surprised his 120-person staff by announcing that he planned over the next three years to raise the salary of even the lowest-paid clerk, customer service representative and salesman to a minimum of $70,000.
“Is anyone else freaking out right now?” Mr. Price asked after the clapping and whooping died down into a few moments of stunned silence. “I’m kind of freaking out.”
If it’s a publicity stunt, it’s a costly one. Mr. Price, who started the Seattle-based credit-card payment processing firm in 2004 at the age of 19, said he would pay for the wage increases by cutting his own salary from nearly $1 million to $70,000 and using 75 to 80 percent of the company’s anticipated $2.2 million in profit this year.
Employees reacting to the news. The average salary at Gravity Payments had been $48,000 year.Credit Matthew Ryan Williams for The New York Times
The paychecks of about 70 employees will grow, with 30 ultimately doubling their salaries, according to Ryan Pirkle, a company spokesman. The average salary at Gravity is $48,000 year.
Mr. Price’s small, privately owned company is by no means a bellwether, but his unusual proposal does speak to an economic issue that has captured national attention: The disparity between the soaring pay of chief executives and that of their employees.
The United States has one of the world’s largest pay gaps, with chief executives earning nearly 300 times what the average worker makes, according to some economists’ estimates. That is much higher than the 20-to-1 ratio recommended by Gilded Age magnates like J. Pierpont Morgan and the 20th century management visionary Peter Drucker.
“The market rate for me as a C.E.O. compared to a regular person is ridiculous, it’s absurd,” said Mr. Price, who said his main extravagances were snowboarding and picking up the bar bill. He drives a 12-year-old Audi, which he received in a barter for service from the local dealer.
“As much as I’m a capitalist, there is nothing in the market that is making me do it,” he said, referring to paying wages that make it possible for his employees to go after the American dream, buy a house and pay for their children’s education.
Under a financial overhaul passed by Congress in 2010, the Securities and Exchange Commission was supposed to require all publicly held companies to disclose the ratio of C.E.O. pay to the median pay of all other employees, but it has so far failed to put it in effect. Corporate executives have vigorously opposed the idea, complaining it would be cumbersome and costly to implement.
Mr. Price started the company, which processed $6.5 billion in transactions for more than 12,000 businesses last year, in his dorm room at Seattle Pacific University with seed money from his older brother. The idea struck him a few years earlier when he was playing in a rock band at a local coffee shop. The owner started having trouble with the company that was processing credit card payments and felt ground down by the large fees charged.
When Mr. Price looked into it for her, he realized he could do it more cheaply and efficiently with better customer service.
The entrepreneurial spirit was omnipresent where he grew up in rural southwestern Idaho, where his family lived 30 miles from the closest grocery store and he was home-schooled until the age of 12. When one of Mr. Price’s four brothers started a make-your-own baseball card business, 9-year-old Dan went on a local radio station to make a pitch: “Hi. I’m Dan Price. I’d like to tell you about my brother’s business, Personality Plus.”
His father, Ron Price, is a consultant and motivational speaker who has written his own book on business leadership.
Dan Price came close to closing up shop himself in 2008 when the recession sent two of his biggest clients into bankruptcy, eliminating 20 percent of his revenue in the space of two weeks. He said the firm managed to struggle through without layoffs or raising prices. His staff, most of them young, stuck with him.
Aryn Higgins at work at Gravity Payments in Seattle. She and her co-workers are going to receive significant pay raises.Credit Matthew Ryan Williams for The New York Times
Mr. Price said he wasn’t seeking to score political points with his plan. From his friends, he heard stories of how tough it was to make ends meet even on salaries that were still well-above the federal minimum of $7.25 an hour.
“They were walking me through the math of making 40 grand a year,” he said, then describing a surprise rent increase or nagging credit card debt.
“I hear that every single week,” he added. “That just eats at me inside.”
Mr. Price said he wanted to do something to address the issue of inequality, although his proposal “made me really nervous” because he wanted to do it without raising prices for his customers or cutting back on service.
Of all the social issues that he felt he was in a position to do something about as a business leader, “that one seemed like a more worthy issue to go after.”
He said he planned to keep his own salary low until the company earned back the profit it had before the new wage scale went into effect.
Hayley Vogt, a 24-year-old communications coordinator at Gravity who earns $45,000, said, “I’m completely blown away right now.” She said she has worried about covering rent increases and a recent emergency room bill.
“Everyone is talking about this $15 minimum wage in Seattle and it’s nice to work someplace where someone is actually doing something about it and not just talking about it,” she said.
The happiness research behind Mr. Price’s announcement on Monday came from Angus Deaton and Daniel Kahneman, a Nobel Prize-winning psychologist. They found that what they called emotional well-being — defined as “the emotional quality of an individual’s everyday experience, the frequency and intensity of experiences of joy, stress, sadness, anger, and affection that make one’s life pleasant or unpleasant” — rises with income, but only to a point. And that point turns out to be about $75,000 a year.
Of course, money above that level brings pleasures — there’s no denying the delights of a Caribbean cruise or a pair of diamond earrings — but no further gains on the emotional well-being scale.
As Mr. Kahneman has explained it, income above the threshold doesn’t buy happiness, but a lack of money can deprive you of it.
Phillip Akhavan, 29, earns $43,000 working on the company’s merchant relations team. “My jaw just dropped,” he said. “This is going to make a difference to everyone around me.”
At that moment, no Princeton researchers were needed to figure out he was feeling very happy.
You're probably all too aware of the major sources of stress in your life -- money, your terrible commute, the construction workers who start jackhammering at 5 a.m. But stress and anxiety don't have to just come from obvious or even negative sources. "There are plenty of chronic strains and low-grade challenges that don't necessarily overwhelm you in the moment, but almost take more of a toll in the long run," says Scott Schieman, Ph.D., professor of sociology at the University of Toronto. These are some of unexpected reasons why you might feel anxious or agitated. By recognizing them for what they are, says Schieman, you can better prepare to cope.
1. Your Significant Other Even if you have a blissfully happy relationship with your live-in partner or spouse, you're both bound to do things that get on each other's nerves. "Early in the relationship, it's usually about space and habits -- like whether you squeeze the toothpaste from the middle or the bottom of the tube," says Ken Yeager, Ph.D., associate professor of psychiatry at the Ohio State University Wexner Medical Center. "Later on, you might clash over parenting style or financial issues, and finding a unified front to face these issues together." So what's the key to surviving and thriving in your life together? Finding balance, says Yeager: spending the right amount of time together (not too much and not too little), making compromises, keeping communication open and honest, and remembering to acknowledge what you love about each other on a daily basis.
2. Everyday Annoyances We're told not to sweat the small stuff, but sometimes it's the little things that have the biggest impact on our mood: the never-ending phone calls with your insurance company, the rude cashier at the grocery store, the 20 minutes you lose looking for a parking space. "We let these things bother us because they trigger unconscious fears," says Yeager -- fears of being seen as irresponsible, of being bullied or embarrassed, or of being late all the time, for example. "Sometimes you need to take a step back and realize that you're doing the best you can given the circumstances."
3. Other People's Stress Stress is contagious, according to a 2014 German study: In a series of experiments, most participants who simply observed others completing a stressful task experienced an increase themselves in production of the stress hormone cortisol -- a phenomenon known as empathic stress. You can also experience stress when someone you know is affected by a traumatic event, like a car crash or a chronic illness. "You start to worry, 'Oh my gosh, could that happen to me?'," says Yeager. "We tend not to think about these things until they hit close to home."
4. Social Media It may seem like Facebook is the only way you keep up with the friends you don't see regularly -- which, during particularly busy times, can be just about all of them. The social network also has a downside, according to a 2015 study from the Pew Research Center: It can make you aware of stressful situations in your friends' lives, which in turn can add more stress to your life. The Pew report didn't find that social media users, overall, had higher levels of stress, but previous studies have suggested that frequent social-media use can be associated with negative body image and prolonged breakup pain.
5. Distraction A distraction can be a good thing then when it takes your mind off of a stressful situation or difficult decision, like when you take a break from work to meet a friend for lunch. But it works the other way, as well: When you're so busy thinking about something else that you can't enjoy what's going on around you, that kind of distraction can be a recipe for stress. Practicing mindfulness gives you brain the refresh it needs, says Richard Lenox, director of the Student Counseling Center at Texas Tech University. Paying full attention to your surroundings when you're walking and driving can help, he adds. "Stress and anxiety tend to melt away when our mind is focused on the present."
6. Your Childhood Traumatic events that happened when you were a kid can continue to affect your stress levels and overall health into adulthood. A 2014 University of Wisconsin-Madison study found that these childhood experiences may actually change parts of the brain responsible for processing stress and emotion. The way you were raised can also have a lasting impact on your everyday angst, suggests a 2014 Johns Hopkins University study. Researchers found that children of parents with social anxiety disorders are more likely to develop "trickle-down anxiety" -- not simply because of their genes, but because of their parents' behaviors toward them such as a lack of warmth and emotion, or high levels of criticism and doubt.
7. Tea And Chocolate You probably know to take it easy on the coffee when you're already feeling on edge. "Caffeine is always going to make stress worse," says Yeager. But you may not think as much about drinking several cups of tea at once, or chowing down on a bar of dark chocolate -- both of which can contain nearly as much caffeine as a cup of joe. "Chocolate is a huge caffeine source," says Yeager. "I know people who don't drink coffee but they'll eat six little candy bars in a two-hour period because they want the same kind of jolt." Too much caffeine, in any form, can cause problems with sleep, digestion, and irritability.
8. Your Expectations When things don't go the way you've planned, do you tend to get upset and act defensively, or do you roll with the punches and set off on a new plan? If it's the former, you could be contributing to a mindset of pessimism and victimization that will slowly wear you down, even when things may not be as bad as they seem. "Your level of serenity is inversely proportionate to your expectations," says Yeager. That doesn't mean you shouldn't set ambitious goals for yourself or settle for less than what you want, of course, but being realistic about what's truly possible is important, as well.
9. Your Reaction To Stress If you tend to deal with stressful situations by working long hours, skipping your workouts, and bingeing on junk food, we've got some bad news: You're only making it worse. "We know that physical activity and healthy foods will help your body better deal with stress, and yet we often avoid them when we need them the most," says Yeager. "People really need to think about this downward spiral we get into and work harder to counteract it."
10. Multitasking Think you're being super efficient by tackling four tasks at once? Chances are you're not -- and it's only decreasing your productivity while increasing your stress. A 2012 University of Irvine study, for example, found that people who responded to emails all day long while also trying to get their work done experienced more heart-rate variability (an indicator of mental stress) than those who waited to respond to all of their emails at one time. Focusing on one task at a time can ensure that you're doing that job to the best of your abilities and getting the most out of it, so you won't have to worry about or go back and fix it later, says Schieman. And don't worry: You'll have enough time to do it all. In fact, you may discover you have more time than you thought.
11. Your Favorite Sport Watching a tight game of college hoops can stress you out -- even if your alma mater wins. "The body doesn't distinguish between 'bad' stress from life or work and 'good' stress caused by game-day excitement," says Jody Gilchrist, a nurse practitioner at the University of Alabama at Birmingham’s Heart and Vascular Clinic. Watching sports can even trigger the body's sympathetic nervous system, releasing adrenaline and reducing blood flow to the heart. Those temporary consequences aren't usually anything to be concerned about, but over time, chronic stress can lead to high blood pressure and increased disease risk. And, of course, it doesn't help if you're adding alcohol and binge-eating to a situation that's already stressful on your body. You may not be able to control the outcome of the game, says Gilchrist, but you can limit its effects on your own body.
12. Digital Devices Whether you're using it for work or play, technology may play a large role in your mental health, says Yeager. Using computers or e-readers too close to bedtime could lead to sleep problems, he says, and spending too much time virtually socializing can make real-life interactions seem extra stressful. (Plus, texting doesn't trigger the same feel-good hormones as face-to-face talk does.) Then there's the dreaded "work creep," says Schieman, when smartphones allow employees to be tethered to their jobs, even during off-hours. "People say they're only going to check email for an hour while they're on vacation, but the problem with email is that they're filled with responsibilities, new tasks, and dilemmas that are going to be hard to compartmentalize and put out of your head once that hour is up."
13. Your (Good) Health While it may not be as stressful as having a chronic illness or getting bad news at the doctor's office, even people in the best shape of their lives worry about their bodies, their diets, and their fitness levels. In fact, people who take healthy living to an extreme may experience some rather unhealthy side effects. People who follow low-carb diets, for example, are more likely to report being sad or stressed out, while those on any kind of restrictive meal plan may feel more tired than usual. And it's not unheard of for someone to become obsessed with healthy eating (known as orthorexia) or working out (gymorexia). Like any form of perfectionism, these problems can be stressful at best, and extremely dangerous at worst.
14. Housework Does folding laundry help you feel calm, or does it make your blood boil? If you're in a living situation where you feel you're responsible for an unfair share of work, even chores you once enjoyed may start to feel like torture. "Dividing up housework and parenting responsibilities can be tricky, especially if both partners work outside the home," says Schieman. "And whether you define that division of labor as equal or unequal can really change your attitude toward it."
15. Uncertainty Stress can be defined as any perceived or actual threat, says Yeager, so any type of doubt that's looming over you can contribute to your anxiety levels on a daily basis. "When you know something could change at any minute, you always have your guard up and it's hard to just relax and enjoy anything." Financial uncertainty may be the most obvious stressor -- not being sure if you'll keep your job during a round of layoffs, or not knowing how you'll pay your credit card bill. Insecurities in other areas of life, like your relationship or your housing status, can eat away at you too.
16. Your Pet No matter how much you love your furry friends, there's no question that they add extra responsibility to your already full plate. Even healthy animals need to be fed, exercised, cleaned up after, and given plenty of attention on a regular basis -- and unhealthy ones can be a whole other story. "Pets can be the most positive source of unconditional love, but at the same time they require an extreme amount of energy," says Yeager. People also tend to underestimate the stress they'll experience when they lose a pet. "I've had people in my office tell me they cried more when their dog died than when their parent died. It's a very emotional connection."
17. Your Education Having a college degree boosts your odds of landing a well-paying job, so although you're less likely to suffer from money-related anxiety, your education can bring on other types of stress, according to a 2014 study by Schieman and his University of Toronto colleagues. His research found that highly educated people were more likely to be stressed out thanks to job pressures, being overworked, and conflicts between work and family. "Higher levels of authority come with a lot more interpersonal baggage, such as supervising people or deciding whether they get promotions," says Schieman. "With that type of responsibility, you start to take things like incompetency and people not doing their jobs more personally, and it bothers you more."
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Excerpt from hubpages.com By Stephanie HicksWhat is Narcissism?Like many other psychological issues, there is a range of narcissism from mild to severe. Because of our inherent ego (as analyzed by Freud), a tendency to want to protect, celeb...
AMSTERDAM—Insecure about your height? You may want to avoid this tiny country by the North Sea, whose population has gained an impressive 20 centimeters in the past 150 years and is now officially the tallest on the planet. Scientists chalk up most of that increase to rising wealth, a rich diet, and good health care, but a new study suggests something else is going on as well: The Dutch growth spurt may be an example of human evolution in action. The study, published online today in the Proceedings of the Royal Society B, shows that tall Dutch men on average have more children than their shorter counterparts, and that more of their children survive. That suggests genes that help make people tall are becoming more frequent among the Dutch, says behavioral biologist and lead author Gert Stulp of the London School of Hygiene & Tropical Medicine.
"This study drives home the message that the human population is still subject to natural selection," says Stephen Stearns, an evolutionary biologist at Yale University who wasn't involved in the study. "It strikes at the core of our understanding of human nature, and how malleable it is." It also confirms what Stearns knows from personal experience about the population in the northern Netherlands, where the study took place: "Boy, they are tall."
For many years, the U.S. population was the tallest in the world. In the 18th century, American men were 5 to 8 centimeters taller than those in the Netherlands. Today, Americans are the fattest, but they lost the race for height to northern Europeans—including Danes, Norwegians, Swedes, and Estonians—sometime in the 20th century.
Just how these peoples became so tall isn't clear, however. Genetics has an important effect on body height: Scientists have found at least 180 genes that influence how tall you become. Each one has only a small effect, but together, they may explain up to 80% of the variation in height within a population. Yet environmental factors play a huge role as well. The children of Japanese immigrants to Hawaii, for instance, grew much taller than their parents. Scientists assume that a diet rich in milk and meat played a major role.
The Dutch have become so much taller in such a short period that scientists chalk most of it up to their changing environment. As the Netherlands developed, it became one of the world's largest producers and consumers of cheese and milk. An increasingly egalitarian distribution of wealth and universal access to health care may also have helped.
Still, scientists wonder whether natural selection has played a role as well. For men, being tall is associated with better health, attractiveness to the opposite sex, a better education, and higher income—all of which could lead to more reproductive success, Stulp says. Yet studies in the United States don't show this. Stulp's own research among Wisconsinites born between 1937 and 1940, for instance, showed that average-sized men had more children than shorter and taller men, and shorter women had more children than those of average height. Taken together, Stulp says, this suggests natural selection in the United States pulls in the opposite direction of environmental factors like diet, making people shorter instead of taller. That may explain why the growth in average American height has leveled off.
Stulp—who says his towering 2-meter frame did not influence his research interest—wondered if the same was true in his native country. To find out, he and his colleagues turned to a database tracking key life data for almost 100,000 people in the country's three northern provinces. The researchers included only people over 45 who were born in the Netherlands to Dutch-born parents. This way, they had a relatively accurate number of total children per subject (most people stop having children after 45) and they also avoided the effects of immigration.
In the remaining sample of 42,616 people, taller men had more children on average, despite the fact that they had their first child at a higher age. The effect was small—an extra 0.24 children at most for taller men—but highly significant. (Taller men also had a smaller chance of remaining childless, and a higher chance of having a partner.) The same effect wasn't seen in women, who had the highest reproductive success when they were of average height. The study suggests this may be because taller women had a smaller chance of finding a mate, while shorter women were at higher risk of losing a child.
Because tall men are likely to pass on the genes that made them tall, the outcome suggests that—in contrast to Americans—the Dutch population is evolving to become taller, Stulp says. "This is not what we've seen in other studies—that's what makes it exciting," says evolutionary biologist Simon Verhulst of the University of Groningen in the Netherlands, who was Stulp's Ph.D. adviser but wasn't involved in the current study. Verhulst points out that the team can't be certain that genes involved in height are actually becoming more frequent, however, as the authors acknowledge.
The study suggests that sexual selection is at work in the Dutch population, Stearns says: Dutch women may prefer taller men because they expect them to have more resources to invest in their children. But there are also other possibilities. It could be that taller men are more resistant to disease, Stearns says, or that they are more likely to divorce and start a second family. "It will be a difficult question to answer.”
Another question is why tall men in Holland are at a reproductive advantage but those in the United States are not. Stulp says he can only speculate. One reason may be that humans often choose a partner who's not much shorter or taller than they are themselves. Because shorter women in the United States have more children, tall men may do worse than those of average height because they're less likely to partner with a short woman.
In the end, Stearns says, the advantage of tall Dutchmen may be only temporary. Often in evolution, natural selection will favor one trend for a number of generations, followed by a stabilization or even a return to the opposite trend. In the United States, selection for height appears to have occurred several centuries ago, leading to taller men, and then it stopped. "Perhaps the Dutch caught up and actually overshot the American men," he says.
Excerpt from huffingtonpost.comThe Roswell, New Mexico, UFO crash of 1947 was the result of -- here it comes, wait for it -- top secret Nazi technology. No alien spacecraft, no alien bodies, but an aircraft called the "Bell" (depicted ab...
A group of biologists was alarmed with the use a new genome-editing technique to modify human DNA in a way that it can become hereditary. The biologists worry that the new technique is so effective and easy to use that some physicians may push ahead with it before its safety can be weigh up. They also want the public to understand the ethical issues surrounding the technique, which could be used to cure genetic diseases, but also to enhance qualities like beauty or intelligence. The latter is a path that many ethicists believe should never be taken.
“You could exert control over human heredity with this technique, and that is why we are raising the issue,” said David Baltimore, a former president of the California Institute of Technology and a member of the group whose paper on the topic was published in the journal Science.
Ethicists have been concerned for decades about the dangers of altering the human germ line — meaning to make changes to human sperm, eggs or embryos that will last through the life of the individual and be passed on to future generations. Until now, these worries have been theoretical. But a technique invented in 2012 makes it possible to edit the genome precisely and with much greater ease. The technique has already been used to edit the genomes of mice, rats and monkeys, and few doubt that it would work the same way in people.
The new genome-editing technique holds the power to repair or enhance any human gene. “It raises the most fundamental of issues about how we are going to view our humanity in the future and whether we are going to take the dramatic step of modifying our own germline and in a sense take control of our genetic destiny, which raises enormous peril for humanity,” said George Daley, a stem cell expert at Boston Children’s Hospital and a member of the group.
The biologists writing in Science support continuing laboratory research with the technique, and few if any scientists believe it is ready for clinical use. Any such use is tightly regulated in the United States and Europe. American scientists, for instance, would have to present a plan to treat genetic diseases in the human germline to the Food and Drug Administration.
The paper’s authors, however, are concerned about countries that have less regulation in science. They urge that “scientists should avoid even attempting, in lax jurisdictions, germ line genome modification for clinical application in humans” until the full implications “are discussed among scientific and governmental organizations.”
Though such a moratorium would not be legally enforceable and might seem unlikely to exert global sway, there is a precedent. In 1975, scientists worldwide were asked to refrain from using a method for manipulating genes, the recombinant DNA technique, until rules had been established.
“We asked at that time that nobody do certain experiments, and in fact nobody did, to my knowledge,” said Baltimore, who was a member of the 1975 group. “So there is a moral authority you can assert from the U.S., and that is what we hope to do.”
Recombinant DNA was the first in a series of ever-improving steps for manipulating genetic material. The chief problem has always been one of accuracy, of editing the DNA at precisely the intended site, since any off-target change could be lethal. Two recent methods, known as zinc fingers and TAL effectors, came close to the goal of accurate genome editing, but both are hard to use. The new genome-editing approach was invented by Jennifer Doudna of the University of California, Berkeley, and Emmanuelle Charpentier of Umea University in Sweden.
Their method, known by the acronym Crispr-Cas9, co-opts the natural immune system with which bacteria remember the DNA of the viruses that attack them so they are ready the next time those same invaders appear. Researchers can simply prime the defense system with a guide sequence of their choice and it will then destroy the matching DNA sequence in any genome presented to it. Doudna is the lead author of the Science article calling for control of the technique and organized the meeting at which the statement was developed.
Though highly efficient, the technique occasionally cuts the genome at unintended sites. The issue of how much mistargeting could be tolerated in a clinical setting is one that Doudna’s group wants to see thoroughly explored before any human genome is edited.
Scientists also say that replacing a defective gene with a normal one may seem entirely harmless but perhaps would not be. “We worry about people making changes without the knowledge of what those changes mean in terms of the overall genome,” Baltimore said. “I personally think we are just not smart enough — and won’t be for a very long time — to feel comfortable about the consequences of changing heredity, even in a single individual.” Many ethicists have accepted the idea of gene therapy, changes that die with the patient, but draw a clear line at altering the germline, since these will extend to future generations. The British Parliament in February approved the transfer of mitochondria, small DNA-containing organelles, to human eggs whose own mitochondria are defective. But that technique is less far-reaching because no genes are edited.
There are two broad schools of thought on modifying the human germline, said R. Alta Charo, a bioethicist at the University of Wisconsin and a member of the Doudna group. One is pragmatic and seeks to balance benefit and risk. The other “sets up inherent limits on how much humankind should alter nature,” she said. Some Christian doctrines oppose the idea of playing God, whereas in Judaism and Islam there is the notion “that humankind is supposed to improve the world.” She described herself as more of a pragmatist, saying, “I would try to regulate such things rather than shut a new technology down at its beginning.”
Other scientists agree with the Doudna group’s message. “It is very clear that people will try to do gene editing in humans,” said Rudolf Jaenisch, a stem cell biologist at the Whitehead Institute in Cambridge, Massachusetts, who was not a member of the Doudna group. “This paper calls for a moratorium on any clinical application, which I believe is the right thing to do.” Writing in Nature last week, Edward Lanphier and other scientists involved in developing the rival zinc finger technique for genome editing also called for a moratorium on human germline modification, saying that use of current technologies would be “dangerous and ethically unacceptable.”
The International Society for Stem Cell Research said Thursday that it supported the proposed moratorium.
The Doudna group calls for public discussion but is also working to develop some more formal process, such as an international meeting convened by the National Academy of Sciences, to establish guidelines for human use of the genome-editing technique.
“We need some principled agreement that we want to enhance humans in this way or we don’t,” Jaenisch said. “You have to have this discussion because people are gearing up to do this.”
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pcmag.com IBM's Watson supercomputer may be saving lives and educating children, but Google's new AI program can master video games without human guidance.
The artificial intelligence system from London-based DeepMind, which Google acquired last year for a reported $400 million, represents a major step toward a future of smart machines.
Computers running the deep Q-network (DQN) algorithm were exposed to 49 retro games on the Atari 2600 and told to play them, without any direction from researchers. Using the same network architecture and tuning parameters, the machines were given only raw screen pixels, available actions, and game score as input.
For each level passed or high score earned, the computer was automatically rewarded with a digital treat.
"Strikingly, DQN was able to work straight 'out of the box' across all these games," DeepMind's Dharshan Kumaran and Demis Hassabis wrote in a blog post. The executives cited classic titles like Breakout, River Raid, Boxing, and Enduro.
The AI crushed even the most expert humans at 29 games, sometimes composing what the creators called "surprisingly far-sighted strategies" that allowed maximum scoring possibilities. It also outperformed previous machine-learning methods in 43 of 49 instances.
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Google DeepMind's findings were presented in a paper published in this week's Nature journal, which describes the key DQN features that allow it to learn.
"This work offers the first demonstration of a general purpose learning agent that can be trained end-to-end to handle a wide variety of challenging tasks," the researchers said. "This kind of technology should help us build more useful products."
Imagine asking the Google app to complete a complex task—like plan a backpacking trip through Europe, for example.
Google's DeepMind also hopes its technology will give researchers new ways to make sense of large-scale data, opening the door to discoveries in fields like climate science, physics, medicine, and genomics.
"And it may even help scientists better understand the process by which humans learn," Kumaran and Hassabis said, citing physicist Richard Feynman, who famously said, "What I cannot create, I do not understand."
For more, see How DeepMind Can Bring Google Artificial Intelligence to Life in the slideshow above.
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Spreading seeds of awareness on this site and within its many forms since 2006.
14 Annual Spins rounds Sol 071120
thank U Mission Control with the way of gratitude for the co-creation and presentation of every piece of information needed in order to complete this mission to disarm dysfunctional patterns Thank you and I’m grateful that I was able to help provide this resource to me and myself and all those who may have you sit and understand it and made it one day find resonate within your field of Attraction so that we may need to maybe get a team there I decided to take another job occupation of your next transition or whatever you choose to focus on next but thank you so much to all the support world-wise that she my homeboys and homegirls over in the Netherlands and Gaia and dr. Diana loopy Philip from France, Alison Maclean, Tolosa Diane Abigail the gfol federation’s confederations and I’ll local Earth groups, dashiki Niro’s the Blu-rays anybody who has been a contributor on this site directly or indirectly providing you help spread through email a different means information that will help raise and lift anybody by not telling him what to do and I appreciate you that I’m not the only religion that may be planting seeds and invited them to investigate for themselves and come to their own understanding and then have the ability to take ownership of their own creation through their own understanding that’s the siren Divinity is about and that’s why we were created to be enough to human beings are it’s time we finish his transition and stop playing games with our probability feels acting like what maybe I’ll be able to work around it there isn’t all roads lead to Rome in the end so he was a program eyelash it’s not going to your face and this is the truth of your life except it start creating from it responsibility for every creation you make all the way down to the thought that’s truly what it’s about we’re about to make a tremendous leap and jump so to speak, was kind of like when the universe itself has created this imagine I can’t even put it into words cuz I don’t have words given no Credence but I invite you I’m honored to have this experience I have one things I cannot even comprehend could cheap or contemplated are received before and it will definitely have any impact in my next transition are eBay’s Road focus on my next project but anyways thank you grateful 14 years they playing and at times her moment of reflection in celebration anytime the turbulence and frequency shift and lots of communication because they’re over there and you’re over here and you’re just too far apart there’s too much interference in between you because of the separation that’s occurring in our own evolutionary stages so many ways to love you like Battlefield thank you president and of course feels cool tribe.net the new entry for fun and have to cancel our society and that’s all I can pull off the top of my head right now in New Zealand and Australia especially the code writers who wrote text eons ago to speak to us right now today and I first had conversation is Remembrance and everybody involved with integrating new variables and help me decide collectively let the new 0 0 1 0 1 1 0 reality in our new home everything will be like more sooner than from here to there were already here there’s nowhere to go nowhere to be no way that she the only thing we have to do is be there now. InJoY!
How Your Mind Affects Your Body
Excerpt from huffingtonpost.comWe are at last beginning to show that there is an intimate and dynamic relationship between what is going on with our feelings and thoughts and what happens in the body. A Time magazine special showed that happiness, h...
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