The Letorians, by Marina Jacobi
April 4, 2018
http://marinajacobi.com
Dear humanity north of your planet is a fleet of spacecrafts ready to enter your fifth dimensional existence.
Marina tell humanity
Tag: cellular (page 2 of 4)
A Failed War On Cancer Sayer Ji, Green Med InfoEver since Richard Nixon officially declared a war on cancer in 1971 through the signing of the National Cancer Act, over a hundred billion dollars of taxpayer money has been spent on research and drug development in an attempt to eradicate the disease, with trillions more spent by the cancer patients themselves, but with disappointing results.Even after four decades of waging full-scale “conventional” (s [...]
Marco Torres, Prevent DiseaseCompounds within garlic produce reactive oxygen species in cancer cells, activating of multiple death cascades and blocking pathways of tumor proliferation. Eating garlic just twice per week reduces cancer risk without any side effects whatsoever.The reason so many people die with conventional cancer treatment is that while damaging healthy cells, chemotherapy also triggers them to secrete a protein that sustains tumour growth and resistance to [...]
Margie King, GuestMagnesium is the fourth most abundant mineral in your body. But few people fully appreciate this miraculous mineral. The human genome project reveals that 3,751 human proteins have binding sites for magnesium.[i] And so far we know this one essential mineral activates over 350 biochemical processes in the body to keep things flowing.Here are just seven good reasons to get more magnesium today. 1. Prevent Migraines. According to University of Vermo [...]
Excerpt from cnet.com Google's Project Fi wireless service has the potential to turn the mobile industry on its head. But not in the way you might expect. Last week, Google announce...
Reuters
With the right expertise in molecular biology, one could start a basic laboratory to modify human embryos using a genome-editing computer technique all for a couple thousand dollars, according to a new report.
Genetic modification has received heightened scrutiny recently following last week’s announcement that Chinese researchers had, for the first time, successfully edited human embryos’ genomes.
The team at Sun Yat-Sen University in Guangzhou, China, used CRISPR (clustered regularly interspaced palindromic repeats), a technique that relies on “cellular machinery” used by bacteria in defense against viruses.
This machinery is copied and altered to create specific gene-editing complexes, which include the wonder enzyme Cas9. The enzyme works its way into the DNA and can be used to alter the molecule from the inside. The combination is attached to an RNA guide that takes the gene-editing complex to its target, telling Cas9 where to operate.
Use of the CRISPR technique is not necessarily relegated to the likes of cash-flush university research operations, according to a report by Business Insider.
"You could conceivably set up a CRISPR lab for $2,000,” he said, according to Business Insider.
Other top researchers have echoed this sentiment.
"Any scientist with molecular biology skills and knowledge of how to work with [embryos] is going to be able to do this,” Jennifer Doudna, a biologist at the University of California, Berkeley, recently told MIT Tech Review, which reported that Doudna co-discovered how to edit genetic code using CRISPR in 2012.
Last week, the Sun Yat-Sen University research team said it attempted to cure a gene defect that causes beta-thalassemia (a genetic blood disorder that could lead to severe anemia, poor growth, skeletal abnormalities and even death) by editing the germ line. For that purpose they used a gene-editing technique based on injecting non-viable embryos with a complex, which consists of a protective DNA element obtained from bacteria and a specific protein.
"I suspect this week will go down as a pivotal moment in the history of medicine," wrote science journalist Carl Zimmer for National Geographic.
Response to the new research has been mixed. Some experts say the gene editing could help defeat genetic diseases even before birth. Others expressed concern.
“At present, the potential safety and efficacy issues arising from the use of this technology must be thoroughly investigated and understood before any attempts at human engineering are sanctioned, if ever, for clinical testing,” a group of scientists, including some who had worked to develop CRISPR, warned in Science magazine.
Meanwhile, the director of the US National Institutes for Health (NIH) said the agency would not fund such editing of human embryo genes.
“Research using genomic editing technologies can and are being funded by NIH,” Francis Collins said Wednesday. “However, NIH will not fund any use of gene-editing technologies in human embryos. The concept of altering the human germline in embryos for clinical purposes ... has been viewed almost universally as a line that should not be crossed.”
Although the discovery of CRISPR sequences dates back to 1987 – when it was first used to cure bacteria of viruses – its successes in higher animals and humans were only achieved in 2012-13, when scientists achieved a revolution by combining the resulting treatment system with Cas9 for the first time.
On April 17, the MIT’s Broad Institute announced that has been awarded the first-ever patent for working with the Crisp-Cas9 system.
The institute’s director, Eric Lander, sees the combination as “an extraordinary, powerful tool. The ability to edit a genome makes it possible to discover the biological mechanisms underlying human biology.”
The system’s advantage over other methods is in that it can also target several genes at the same time, working its way through tens of thousands of so-called 'guide' RNA sequences that lead them to the weapon to its DNA targets.
Meanwhile, last month in the UK, a healthy baby was born from an embryo screened for genetic diseases, using karyomapping, a breakthrough testing method that allows doctors to identify about 60 debilitating hereditary disorders.
I Am Entitled To Miracles Lessons 77 - 80In Which We Continue Our Creative Self-IdentityEpisode IIThe Cellular Mind Training Serieswww.themasterteacher.tv
I Am The Light Of The World Lessons 61 - 66In Which We Continue Our Creative Self-IdentityEpisode IIThe Cellular Mind Training Serieswww.themasterteacher.tv
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M. Florio and W. Huttner / Max Planck Institute |
Excerpt from nbcnews.com
By Tia Ghose
ave the way for the rise of human intelligence by dramatically increasing the number of neurons found in a key brain region.
This gene seems to be uniquely human: It is found in modern-day humans, Neanderthals and another branch of extinct humans called Denisovans, but not in chimpanzees.
By allowing the brain region called the neocortex to contain many more neurons, the tiny snippet of DNA may have laid the foundation for the human brain's massive expansion.
"It is so cool that one tiny gene alone may suffice to affect the phenotype of the stem cells, which contributed the most to the expansion of the neocortex," said study lead author Marta Florio, a doctoral candidate in molecular and cellular biology and genetics at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany.
She and her colleagues found that the gene, called ARHGAP11B, is turned on and highly activated in the human neural progenitor cells, but isn't present at all in mouse cells. This tiny snippet of DNA, just 804 genetic bases long, was once part of a much longer gene. Somehow, this fragment was duplicated, and the duplicated fragment was inserted into the human genome.
In follow-up experiments, the team inserted and turned on this DNA snippet in the brains of mice. The mice with the gene insertion grew what looked like larger neocortex regions.
The researchers reviewed a wide variety of genomes from modern-day and extinct species — confirming that Neanderthals and Denisovans had this gene, while chimpanzees and mice do not. That suggests that the gene emerged soon after humans split off from chimpanzees, and that it helped pave the way for the rapid expansion of the human brain.
Florio stressed that the gene is probably just one of many genetic changes that make human cognition special.
The gene was described in a paper published online Thursday by the journal Science.
Excerpt from mercurynews.comThe federal government's top communications regulator on Wednesday called for strong new rules to bar Internet and wireless providers from blocking, slowing or discriminating against consumers' access to particular websi...
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| Using designer genes, researchers at UB and Harvard were able to 'turn on' specific neurons in the brainstem that result in deep sleep. |
medicalxpress.com
(Medical Xpress)—A sleep-promoting circuit located deep in the primitive brainstem has revealed how we fall into deep sleep. Discovered by researchers at Harvard School of Medicine and the University at Buffalo School of Medicine and Biomedical Sciences, this is only the second "sleep node" identified in the mammalian brain whose activity appears to be both necessary and sufficient to produce deep sleep.
"The close association of a sleep center with other regions that are critical for life highlights the evolutionary importance of sleep in the brain," says Caroline E. Bass, assistant professor of Pharmacology and Toxicology in the UB School of Medicine and Biomedical Sciences and a co-author on the paper.
The researchers found that a specific type of neuron in the PZ that makes the neurotransmitter gamma-aminobutyric acid (GABA) is responsible for deep sleep. They used a set of innovative tools to precisely control these neurons remotely, in essence giving them the ability to turn the neurons on and off at will.
"These new molecular approaches allow unprecedented control over brain function at the cellular level," says Christelle Ancelet, postdoctoral fellow at Harvard School of Medicine. "Before these tools were developed, we often used 'electrical stimulation' to activate a region, but the problem is that doing so stimulates everything the electrode touches and even surrounding areas it didn't. It was a sledgehammer approach, when what we needed was a scalpel."
"To get the precision required for these experiments, we introduced a virus into the PZ that expressed a 'designer' receptor on GABA neurons only but didn't otherwise alter brain function," explains Patrick Fuller, assistant professor at Harvard and senior author on the paper. "When we turned on the GABA neurons in the PZ, the animals quickly fell into a deep sleep without the use of sedatives or sleep aids."
How these neurons interact in the brain with other sleep and wake-promoting brain regions still need to be studied, the researchers say, but eventually these findings may translate into new medications for treating sleep disorders, including insomnia, and the development of better and safer anesthetics.
"We are at a truly transformative point in neuroscience," says Bass, "where the use of designer genes gives us unprecedented ability to control the brain. We can now answer fundamental questions of brain function, which have traditionally been beyond our reach, including the 'why' of sleep, one of the more enduring mysteries in the neurosciences."
In “She Used to Be In A Wheelchair – The TED Talk That Comes With a Warning” I showcase Dr. Terry Wahls who successfully reversed her debilitating multiple sclerosis with the application of nutrients and meditation. She talks about the importance “minding your mitochondria” and how lifestyle, diet and environment can switch genes on or off. Similarly, there are people reversing ALS or Lou Gehrig’s disease using similar methods.What’s [...]
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Dealing with the Narcissist ~ A Message to Lightworkers via Caroline Oceana Ryan – March 19 2018
https://carolineoceanaryan.com/2018/03/19/a-message-to-lightworkers-march-19-2018/
A Message to Lightworkers via Caroline Oceana Ryan – March 19 2018
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