Date: May 1, 2015

Jane Goodall Says SeaWorld ‘Should Be Closed Down’

Jane Goodall


Excerpt from huffingtonpost.com

NEW YORK -- Jane Goodall wants to see SeaWorld go extinct.
The 81-year-old primatologist said whales and dolphins should never be held in captivity, and that the entertainment company known for its orca shows should be shuttered.

“They definitely should be closed down,” Goodall said in an interview with The Huffington Post earlier this month. 

She’s not alone. SeaWorld’s stock price has been plummeting since July 2013, when CNN released the documentary “Blackfish." The film exposed the misery endured by SeaWorld's trained orca and the dangers posed to trainers working with stressed-out carnivorous whales. 

seaworld stock
SeaWorld's stock price has declined precipitously since the 2013 release of "Blackfish."

One of the problems highlighted in "Blackfish" is that cetacea, the family of aquatic mammals that includes whales, dolphins and porpoises, communicate with sonar-like sound waves. When confined to tanks, Goodall noted, those waves echo back and create a hellish cacophony for the animals.

“When they are contained in these tanks … that is acoustical hell,” said Goodall, adding that her nonprofit organization, the Jane Goodall Institute, is urging aquariums across the country to free their whales. “The sounds bounce back from the walls of the tank.”

SeaWorld aggressively refuted many of the film's claims, including allegations that its whales were unhealthy and that the company tried to cover up details surrounding the 2010 death of trainer Dawn Brancheau, who was mauled by an orca. 

After the release of "Blackfish," SeaWorld saw a rapid decline in visitors, and with that, in the price of shares. But on Monday, Goldman Sachs upgraded the stock, optimistic that the company can retool its image as consumers start forgetting about the blockbuster documentary.

"Jane Goodall is a respected scientist and advocate for the world’s primates, but we couldn’t disagree more with her on this," Becca Bides, a SeaWorld spokeswoman, said in an emailed statement. 

"Zoos and marine mammal parks like SeaWorld allow people to experience animals in a way that is inspiring and educational."
Asked about the allegation that SeaWorld's tanks are detrimental to whales, Bides denied the claim, arguing that they are specially crafted to keep underwater noise levels quieter than the ambient ocean.

As of last December, SeaWorld held 22 orcas in its three U.S. marine parks, five of which were caught in the wild, according to the nonprofit advocacy group Whale and Dolphin Conservation. A total of 57 orcas are held in captivity around the world, the group notes. At least 160 orcas have died in captivity since 1961, and an additional 30 pregnant whales have miscarried or had stillborn calves.

Goodall said she remains hopeful that humans are gaining a greater sense of empathy for animals and losing interest in watching them perform for entertainment.

“It’s not only that they’re really big, highly intelligent and social animals so that the capture and confinement in itself is cruel,” she said of the captive orcas, but also that “they have emotions like ours.”
She welcomed the decision by Ringling Bros. and Barnum & Bailey Circus to eliminate elephants in its shows by 2018.

“If you see what happens to those baby elephants, the way they’re trained, it’s absolutely chilling,” said Goodall, who had a pendant in the shape of Africa hanging from her necklace. “They lose all of their young elephant playfulness, and then they can be trained.”

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Lab for genetic modification of human embryos just $2,000 away – report


Reuters / Christian Charisius



Reuters

With the right expertise in molecular biology, one could start a basic laboratory to modify human embryos using a genome-editing computer technique all for a couple thousand dollars, according to a new report.

Genetic modification has received heightened scrutiny recently following last week’s announcement that Chinese researchers had, for the first time, successfully edited human embryos’ genomes. 
The team at Sun Yat-Sen University in Guangzhou, China, used CRISPR (clustered regularly interspaced palindromic repeats), a technique that relies on “cellular machinery” used by bacteria in defense against viruses. 

This machinery is copied and altered to create specific gene-editing complexes, which include the wonder enzyme Cas9. The enzyme works its way into the DNA and can be used to alter the molecule from the inside. The combination is attached to an RNA guide that takes the gene-editing complex to its target, telling Cas9 where to operate. 

Use of the CRISPR technique is not necessarily relegated to the likes of cash-flush university research operations, according to a report by Business Insider. 


Geneticist George Church, who runs a top CRISPR research program at the Harvard Medical School, said the technique could be employed with expert knowledge and about half of the money needed to pay for an average annual federal healthcare plan in 2014 -- not to mention access to human embryos. 

"You could conceivably set up a CRISPR lab for $2,000,” he said, according to Business Insider. 

Other top researchers have echoed this sentiment. 

"Any scientist with molecular biology skills and knowledge of how to work with [embryos] is going to be able to do this,” Jennifer Doudna, a biologist at the University of California, Berkeley, recently told MIT Tech Review, which reported that Doudna co-discovered how to edit genetic code using CRISPR in 2012. 

Last week, the Sun Yat-Sen University research team said it attempted to cure a gene defect that causes beta-thalassemia (a genetic blood disorder that could lead to severe anemia, poor growth, skeletal abnormalities and even death) by editing the germ line. For that purpose they used a gene-editing technique based on injecting non-viable embryos with a complex, which consists of a protective DNA element obtained from bacteria and a specific protein. 

"I suspect this week will go down as a pivotal moment in the history of medicine," wrote science journalist Carl Zimmer for National Geographic.


Response to the new research has been mixed. Some experts say the gene editing could help defeat genetic diseases even before birth. Others expressed concern. 

“At present, the potential safety and efficacy issues arising from the use of this technology must be thoroughly investigated and understood before any attempts at human engineering are sanctioned, if ever, for clinical testing,” a group of scientists, including some who had worked to develop CRISPR, warned in Science magazine. 

Meanwhile, the director of the US National Institutes for Health (NIH) said the agency would not fund such editing of human embryo genes. 

“Research using genomic editing technologies can and are being funded by NIH,” Francis Collins said Wednesday. “However, NIH will not fund any use of gene-editing technologies in human embryos. The concept of altering the human germline in embryos for clinical purposes ... has been viewed almost universally as a line that should not be crossed.”

Although the discovery of CRISPR sequences dates back to 1987 – when it was first used to cure bacteria of viruses – its successes in higher animals and humans were only achieved in 2012-13, when scientists achieved a revolution by combining the resulting treatment system with Cas9 for the first time. 


On April 17, the MIT’s Broad Institute announced that has been awarded the first-ever patent for working with the Crisp-Cas9 system. 

The institute’s director, Eric Lander, sees the combination as “an extraordinary, powerful tool. The ability to edit a genome makes it possible to discover the biological mechanisms underlying human biology.”

The system’s advantage over other methods is in that it can also target several genes at the same time, working its way through tens of thousands of so-called 'guide' RNA sequences that lead them to the weapon to its DNA targets. 

Meanwhile, last month in the UK, a healthy baby was born from an embryo screened for genetic diseases, using karyomapping, a breakthrough testing method that allows doctors to identify about 60 debilitating hereditary disorders.

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